Navigation Links
Toward an improved test for adulterated heparin
Date:9/21/2011

Scientists are reporting refinement of a new test that promises to help assure the safety of supplies of heparin, the blood thinner taken by millions of people worldwide each year to prevent blood clots. The test can quickly and economically detect adulterants, including the substance responsible for hundreds of illnesses and deaths among patients taking heparin in 2008. The report appears in ACS' journal Analytical Chemistry.

David Keire and Cynthia Sommers explain that in 2008, a number of patients died and hundreds patients became seriously ill after receiving batches of the blood thinner that had been adulterated. The U.S. Food and Drug Administration announced a major recall of heparin, and scientists identified the culprit a substance called "oversulfated chondroitin sulfate" (OSCS). OSCS is a synthetic dietary supplement derived from chondroitin sulfate type A that some people take to treat osteoarthritis. Like heparin, OSCS also prevents blood from forming dangerous clots. But unlike heparin, OSCS can trigger potentially fatal anaphylactic reactions in sensitive individuals. Scientists concluded that OSCS, which is inexpensive, had been intentionally added to heparin as a so-called "economically motivated adulterant" (EMA), to boost profits. Current tests to detect EMAs in heparin are difficult to perform and must be done in laboratories.

To overcome these challenges, the researchers developed a simple color test in which normal heparin samples turn red in color but OSCS contaminated samples do not change color. In the present study, Keire and Sommers wanted to know whether their test could detect additional EMAs. They found that the test could detect several other possible EMAs, such as those that could be made by over-sulfation of waste products formed during heparin production. The researchers say that, on the basis of their results, a portable test to detect even tiny amounts of different EMAs could be developed to insure the safety of the heparin supply chain.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Related medicine news :

1. Key signal that prompts production of insulin-producing beta cells points way toward diabetes cure
2. An advance toward an electronic nose urine test for TB
3. IOM report calls for cultural transformation of attitudes toward pain and its prevention and management
4. A step toward controlling Huntingtons disease?
5. Toward a more efficient therapy for a specific form of leukemia
6. Attitudes toward end-of-life care: A survey of cancer patients and others in Korea
7. NIH grant for the move toward clinical trials targeting the lysosomal storage disease MPSIIIB
8. U.S. Pushes School Cafeterias Toward Healthier Offerings
9. Toward a vaccine for methamphetamine abuse
10. Negative attitudes toward fat bodies going global, study finds
11. Tiny gems take big step toward battling cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... August 18, 2017 , ... More than 20,000 pairs of shoes made their ... to an ambitious venture that conjoined the passions of an NBA star, a Liberty ... Liberty community. These shoes will save lives from the rampant infections transmitted through the ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... a highly specialized asset-light logistics provider of complex transport solutions for mission-critical ... to purchase Unitrans International Corporation, a division of Roadrunner Transportation Systems, Inc. ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... of “Vision & Hearing,” advocating for active, healthy lifestyles and highlighting the importance ... for individuals with hearing impairments and shares the latest innovations in hearing aid ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... handheld devices. Through an educational webinar, they will present the line of epMotion ... to learn how easy you can automate everyday pipetting tasks. , Ideal for ...
(Date:8/18/2017)... ... August 18, 2017 , ... Hernandez Insurance ... to communities throughout the greater DC region, is inaugurating a “New Leash On ... local animals and training them to be companions for veterans in need. , ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... 7, 2017 Diplomat Pharmacy, Inc. (NYSE: ... as president, effective Aug. 7, 2017. ... to pursue other interests and will serve as president emeritus ... has served us in multiple leadership roles since he joined ... 2015 and has provided decisive, strategic leadership which continues to ...
(Date:8/4/2017)... CINCINNATI , Aug. 3, 2017  Agragen, ... science company active in the biopharmaceutical, nutraceutical, and ... its development of its lead drug candidates, AGR131.  ... a proinflammatory cytokine from the blood of patients ... psoriasis, and inflammatory bowel disease. ...
(Date:8/2/2017)... Ore. , Aug. 2, 2017  Life Flight Network ... Agreement. The agreement improves patient care and operational efficiency for ... Springfield , Cottage Grove , ... level medical transportation. PeaceHealth and Life Flight Network work collaboratively ... available during transport, or when a time sensitive emergency exists. ...
Breaking Medicine Technology: