Navigation Links
Toward a pill to enable celiac patients to eat foods containing gluten
Date:12/19/2012

Scientists are reporting an advance toward development of a pill that could become celiac disease's counterpart to the lactase pills that people with lactose intolerance can take to eat dairy products without risking digestive upsets. They describe the approach, which involves an enzyme that breaks down the gluten that causes celiac symptoms, in the Journal of the American Chemical Society.

Justin Siegel, Ingrid Swanson Pultz and colleagues explain that celiac disease is an autoimmune disorder in which the gluten in wheat, rye or barley products causes inflammation in the digestive tract. Enzymes in the stomach break down gluten into smaller pieces, called peptides. For most people, these peptides are harmless. But for the 2 million-3 million Americans with celiac disease, the peptides trigger an autoimmune response and painful symptoms. Currently, the only treatment is a gluten-free diet. However, the scientists reasoned that if an enzyme could further break down the offending peptides in the stomach, celiac patients might be able to eat gluten-containing foods.

They describe discovery of a naturally occurring enzyme that has some of the ideal properties for doing so. The scientists modified the enzyme in the laboratory so that it would meet all the necessary criteria. The new enzyme (called KumaMax) broke down more than 95 percent of a gluten peptide implicated in celiac disease in acidic conditions like those in the stomach. "These combined properties make the engineered [enzyme] a promising candidate as an oral therapeutic for celiac disease," say the researchers.


'/>"/>
Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related medicine news :

1. Enzymes may point toward better therapies for prediabetes
2. Toward competitive generic drug prices in Canada
3. Youth with autism gravitate toward STEM majors in college -- if they get there
4. Protein tug of war points toward better therapies for cardiovascular disease
5. Study reveals teenage patients attitude towards social media and privacy
6. Researchers identify possible key to slow progression toward AIDS
7. Toward a better material for hip replacement and other joint implants
8. An advance toward a flu-fighting nasal spray
9. Prototype represents a step toward enhanced soft-tissue tomography
10. Heatwaves to move toward coasts, study finds
11. Field guide to the Epstein-Barr virus charts viral paths toward cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... Hastings and Hastings, a law firm in Arizona that focuses ... representation client review requests for slip and fall accidents in ... the number of slip and fall related accidents that happen ... that said, a large number of injury victims are requesting ... Hastings and Hastings is a personal injury firm in Arizona ...
(Date:1/22/2015)... January 23, 2015 LunaDress, with its top ... fashion industry. Now, the business is showing its latest designs ... dresses. , According to the company’s CEO, all the fresh ... offered with big discounts, up to 80% off. All the ...
(Date:1/22/2015)... Glendale, AZ (PRWEB) January 22, 2015 Padre ... a long supporter of Pro Player Health Alliance ... with Padre Murphy's in getting everyone, including NFL greats, treated ... one of the leading groups supporting the cause in the ...
(Date:1/22/2015)... Blue Cross and Blue Shield of Minnesota (Blue Cross) wants ... “Live Fearless.” , The “Faces of Fearless” campaign ... how they or someone they know has faced a challenge, ... moment. By telling these types of stories through livefearlessmn.com, participants ...
(Date:1/22/2015)... A new white paper by The Beryl ... the long-term care environment as well as provides recommendations ... paper, “The Power of Person-Centeredness in Long-Term Care: A ... the patient, resident and family experience in long-term care ...
Breaking Medicine News(10 mins):Health News:Hastings and Hastings Reports a Record Number of Client Review Requests for Slip and Fall Accidents in 2014 2Health News:LunaDress Shows The Latest Styles Of Wedding Dresses In 2015 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3
... Patients who underwent a rotator cuff repair surgery experienced pain ... according to a new study presented at the 2009 American ... Rotator cuff tears can be caused by a traumatic event ... period of time due to wear and tear, which is ...
... were less prone to relapse , , FRIDAY, Feb. 27 ... with infertility and menstrual disorders may also help treat ... cabergoline (Dostinex), rats addicted to alcohol decreased their drinking ... relapsing, a study by researchers at the University of ...
... Casa Saba ("Saba,","GCS," "the Company" or "the Group") (NYSE: ... of pharmaceutical products, beauty aids, personal care and,consumer goods, ... and operating results for the fourth,quarter of 2008. , ... (All December 2007 figures are expressed ...
... Shapiro, MD, and Joan Rankin Shapiro, PhD, have collaborated ... tumor research center at Barrow Neurological Institute at St. ... patient care and research, the Shapiros have established a ... , "The endowed chair represents our desire to give ...
... finds patient-physician relationship is entitled to ... In a legal victory that ... competition, an Arkansas state court has ... hospital system, acted improperly by inappropriately ...
... Pa., Feb. 27 Governor Edward ... the following nominations subject to Senate confirmation:State Board ... -- reappointmentState Board of Examiners of Nursing Home ... Rendell administration is committed to creating a first-rate ...
Cached Medicine News:Health News:Hormone Drug May Help Drinkers Stay Sober 2Health News:Grupo Casa Saba Announces 4Q08 Earnings Results 2Health News:Grupo Casa Saba Announces 4Q08 Earnings Results 3Health News:Grupo Casa Saba Announces 4Q08 Earnings Results 4Health News:Grupo Casa Saba Announces 4Q08 Earnings Results 5Health News:A lifetime of paying it forward 2Health News:Physicians Hail Arkansas Court Victory Against Baptist Health 2
(Date:1/23/2015)... ANGELES , Jan. 23, 2015 A lot of ... best methods for treating  certain illnesses, injuries, or conditions. As ... replace previous treatment methods with ones that they consider to ... hernias, there is not one textbook method of treatment that ...
(Date:1/23/2015)... Jan. 23, 2015  The Partnership to Fight Chronic Disease (PFCD) released ... care leaders and a new study analyzing the impact of increased ... a nationwide coalition working to educate policy makers and the public ... Capitol was focused on how the Iowa ...
(Date:1/23/2015)... 2015  Northwest Biotherapeutics, Inc. (NASDAQ: NWBO )("NW Bio"), ... operable and inoperable solid tumor cancers, announced today that CEO ... Annual Phacilitate Immunotherapy Forum in Washington D.C. ... take place on January 26 at 10:30 a.m. EST at ...
Breaking Medicine Technology:No One-Size-Fits-All Remedy for Hernia Correction 2New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3
... , , PHOENIX, ... published two new publications on hormone therapies and their effects on ... , Cardiovascular disease caused by atherosclerosis, or the build-up ... of American women--40% of total deaths--and the rate of mortality is ...
... OMER and MIGDAL HA,EMEK, Israel, August 3 ,Medigus ... visualization,medical devices, and Tower Semiconductor, Ltd. (Nasdaq: ... today announced successful,sampling of a new CMOS imager that ... its new medical devices camera; the smallest of its,kind ...
Cached Medicine Technology:TWO NEW KLRI PEER-REVIEWED PUBLICATIONS: Hormone Therapy May Reduce Atherosclerosis in Women Close to Menopause; Growth Hormone May Increase Risk of Diabetes, Improve Lipid Profile in Men 2TWO NEW KLRI PEER-REVIEWED PUBLICATIONS: Hormone Therapy May Reduce Atherosclerosis in Women Close to Menopause; Growth Hormone May Increase Risk of Diabetes, Improve Lipid Profile in Men 3Medigus and Tower Semiconductor Announce World's Smallest Medical Video Camera Based on Advanced CMOS Image Sensor 2Medigus and Tower Semiconductor Announce World's Smallest Medical Video Camera Based on Advanced CMOS Image Sensor 3Medigus and Tower Semiconductor Announce World's Smallest Medical Video Camera Based on Advanced CMOS Image Sensor 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: