Navigation Links
Toward a more efficient therapy for a specific form of leukemia
Date:6/14/2011

Chronic myeloid leukemia (CML) is a particular form of leukemia or cancer of the bone marrow, which can be treated with targeted imatinib. However, in some cases this medicine has no effect. Researchers at the VIB Vesalius Research Centre, K.U. Leuven, under the direction of Peter Carmeliet, have investigated the role of placental growth factor (PlGF) in mice with CML. Blocking this growth factor increases the life expectancy of these mice, even in those resistant to imatinib.

Chronic myeloid leukemia (CML)

In our body, white blood cells combat foreign intruders, such as viruses and bacteria. In chronic myeloid leukemia, the formation of granulocytes, a particular type of white blood cells, is disturbed. The cells in the bone marrow which should grow into white blood cells show an uncontrolled increase in numbers as a result of a disruption in the maturing process. This uncontrolled growth may damage various tissues and adversely affect the production of normal blood cells in the bone marrow. A shortage of white blood cells makes patients more susceptible to infection.

The Philadelphia chromosome and imatinib

Under normal circumstances, our body very accurately regulates the production of white blood cells. This process is triggered by targeted activation of tyrosine kinase. In most forms of CML, a deviant chromosome is present - the Philadelphia chromosome - which gives rise to BCR-ABL1 fusion kinase. This kinase causes the trouble, leading to the increase in CML cells. Existing medicines (imatinib) therefore target this kinase.

While the effect of imatinib in CML patients is usually quite favorable, the use of imatinib is often not sufficient to remove the diseased cells from the body. Sometimes the disease is already too advanced at the start of treatment, or there is resistance.

Placental growth factor

Researchers from the team headed by Peter Carmeliet have stu
'/>"/>

Contact: Evy Vierstraete
info@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Attitudes toward end-of-life care: A survey of cancer patients and others in Korea
2. NIH grant for the move toward clinical trials targeting the lysosomal storage disease MPSIIIB
3. U.S. Pushes School Cafeterias Toward Healthier Offerings
4. Toward a vaccine for methamphetamine abuse
5. Negative attitudes toward fat bodies going global, study finds
6. Tiny gems take big step toward battling cancer
7. Top scientists unite to develop global scientific strategy Towards An HIV Cure
8. Toward a fast, simple test for detecting cholera rampaging in 40 countries
9. Major step taken toward an open and shared digital brain atlasing framework
10. Warning about benevolent sexism and mens apparently positive attitudes towards women
11. Early Steps Toward an Alzheimers Blood Test
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 19, 2014 Eufaula, Oklahoma, located just ... Eufaula, the state’s largest lake with more than 600 ... home to a little more than 3,000 residents, hosted ... Saturday, the 6th of December. , Featuring Santa, Christmas ... downtown Eufaula on Main Street. Narconon Arrowhead’s parade ...
(Date:12/19/2014)... An evening dress is perfect for any occasion and is ... dresses retailer, has unveiled its new selection of evening dresses. ... shopping platform. Customers can view more at its ... been accepted and praised by customers for many years. It ... clients. In order to expand its market share, the company ...
(Date:12/19/2014)... 2014 The print component of Vision ... subscription of the Toronto Star, with a circulation of ... The digital component is distributed nationally through a vast ... news sites and partner outlets. To explore the digital ... The publication features an exclusive interview with Mark ...
(Date:12/19/2014)... The intestinal bacteria that cause inflammatory bowel disease, which ... researchers report. The findings, published recently in the ... to prevent the disease and treat the 1.6 million ... "The intestinal bacteria, or ,gut microbiome, you develop ... impact on your health for the rest of your ...
(Date:12/19/2014)... Dec. 19, 2014 (HealthDay News) -- Potentially illness-causing E. ... bought at farmers markets, according to a new study. ... 50 vendors from 13 farmers markets in Los Angeles ... area. Out of almost 150 samples tested, 24 percent ... for salmonella, according to the researchers. Both types ...
Breaking Medicine News(10 mins):Health News:Narconon Arrowhead Debuts Float at Checotah and Eufaula Christmas Parades 2Health News:Narconon Arrowhead Debuts Float at Checotah and Eufaula Christmas Parades 3Health News:Attractive Evening Dresses Announced by Discount-Dress.com 2Health News:Mark DeMontis, Founder of Courage Canada, shares his passion for bringing hockey to those affected by blindness in Mediaplanet’s “Vision and Hearing” campaign 2Health News:Crohn's, Colitis May Have Genetic Underpinnings, Study Finds 2Health News:E. Coli Germs Found on Farmers Market Herbs 2
... Safety and Efficacy Study of Zolpidem Tartrate ... an As-Needed BasisEvaluation of Ondansetron Augmentation in ... May 21 Transcept Pharmaceuticals, Inc. (Nasdaq: ... company focused on the development and commercialization ...
... offers patients better results and quicker recovery as ... currently on the market; Now available in powerful ... Palomar Medical Technologies, Inc. (Nasdaq: PMTI ... systems for cosmetic treatments, announced today the success ...
... Inc. (MDLH. PK) ( http://www.mitcanada.ca http://www.mitinvest.ca ), ... the Joint Venture Agreement with its Chinese partners. , ... most recent trip to China having completed the negotiations and ... has also received an initial order of 120 Agro-Jet(R) for ...
... Challenging Anatomy Consistent with Superior Results from Randomized ... presented today at EuroPCR from an international, post-approval, ... Everolimus Eluting Coronary Stent System demonstrated low rates ... and major adverse cardiac events (MACE) in a ...
... finds many women use spending sprees to boost emotional well-being ... -- When dealing with financial worries, some women may actually ... shows. , The poll of 700 women found that 79 ... themselves an emotional boost. About 40 percent listed "depression" and ...
... compared to vaginal birth newborns, researchers say , , THURSDAY, ... elective, repeat cesarean section delivery are nearly twice as ... unit (NICU) than those born vaginally after the mother ... , These c-section babies are also more likely to ...
Cached Medicine News:Health News:Transcept Pharmaceuticals Presents Data from Studies of Two Product Candidates at Annual Meeting of the American Psychiatric Association 2Health News:Transcept Pharmaceuticals Presents Data from Studies of Two Product Candidates at Annual Meeting of the American Psychiatric Association 3Health News:Transcept Pharmaceuticals Presents Data from Studies of Two Product Candidates at Annual Meeting of the American Psychiatric Association 4Health News:New Clinical Data Shows Significant Improvement in the Appearance of Fat Using SlimLipo(TM) Laser 2Health News:New Clinical Data Shows Significant Improvement in the Appearance of Fat Using SlimLipo(TM) Laser 3Health News:New Clinical Data Shows Significant Improvement in the Appearance of Fat Using SlimLipo(TM) Laser 4Health News:MIT is pleased to announce that it has signed the Joint Venture agreement with its Chinese partners and has received an initial order of 120 units for Animal vaccination 2Health News:Abbott's XIENCE V(R) Demonstrates Impressive Low Rates of Repeat Procedure, Stent Thrombosis and Major Adverse Cardiac Events in Complex, 'Real World' Patients in SPIRIT V Study 2Health News:Abbott's XIENCE V(R) Demonstrates Impressive Low Rates of Repeat Procedure, Stent Thrombosis and Major Adverse Cardiac Events in Complex, 'Real World' Patients in SPIRIT V Study 3Health News:Abbott's XIENCE V(R) Demonstrates Impressive Low Rates of Repeat Procedure, Stent Thrombosis and Major Adverse Cardiac Events in Complex, 'Real World' Patients in SPIRIT V Study 4Health News:Abbott's XIENCE V(R) Demonstrates Impressive Low Rates of Repeat Procedure, Stent Thrombosis and Major Adverse Cardiac Events in Complex, 'Real World' Patients in SPIRIT V Study 5Health News:Abbott's XIENCE V(R) Demonstrates Impressive Low Rates of Repeat Procedure, Stent Thrombosis and Major Adverse Cardiac Events in Complex, 'Real World' Patients in SPIRIT V Study 6Health News:Shop 'Til You Drop: You May Feel Better 2Health News:Risk to Baby Rises With Repeat C-Sections 2Health News:Risk to Baby Rises With Repeat C-Sections 3
(Date:12/19/2014)... Ill. , Dec. 19, 2014   Hospira, ... leading provider of injectable drugs and infusion technologies, today ... Morgan 33rd Annual Healthcare Conference on Wednesday, Jan. 14, ... presentation is scheduled to begin at 10:30 a.m. Pacific ... available to all interested parties through a live audiocast ...
(Date:12/19/2014)... -- Monarch America Inc. (OTCQB: CANK) ("Monarch America" or the ... this review of the Company,s recent achievements and strategic ... this past year, we achieved many of our early ... say that Monarch America is in a stronger and ... stated Eric Hagen , CEO of Monarch America ...
(Date:12/19/2014)... , Dec. 18, 2014 Somewhere between dropping ... health was forgotten. But Audicus , a next-generation ... better this new year. Hearing loss is ... aging population, though it is often unaddressed. Forty-eight million ... has a hearing aid, mainly due to price. Hearing ...
Breaking Medicine Technology:Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3Audicus Will Help People Resolve to Hear Better in 2015 2
... 1, 2010 ACCESS PHARMACEUTICALS, ... a biopharmaceutical company leveraging its proprietary drug-delivery ... supportive care and diabetes, announced it has ... recently enacted Patient Protection and Affordable Care Act, cash ...
... 2010 The National Quality Forum (NQF) announces ... eight member councils.   NQF is ... the quality of American healthcare by setting national ... consensus standards for measuring and publicly reporting on ...
Cached Medicine Technology:Access Pharmaceuticals Awarded $1.5 Million in Section 48D Grants 2National Quality Forum Members Elect New Council Leaders 2
... deliver critical performance for all vacuum requirements. ... pump performance to suit all applications. The ... checking of proper oil levels at a ... designed to work with all Thermo Savant ...
... is a combination instrument bringing together a 4 ... Pump. It is designed to handle the rigors ... Combines a Refrigerated Cold Trap + Oil-free Pump ... connections. , TEFLON materials ...
... two-stage, oil-sealed, rotary vane vacuum pumps specifically ... pump comes complete with a GBORK (Gas ... Mist Filter (EMF-10). The GBORK allows the ... keep the oil clean without losing oil. ...
... HydroTech vacuum pump is perfect for electrophoresis ... a continuous vacuum of greater than 29 ... works very well with the Model 583 ... fittings for 1/4 and 3/8 inch ID ...
Medicine Products: