Navigation Links
Toward a more efficient therapy for a specific form of leukemia
Date:6/14/2011

Chronic myeloid leukemia (CML) is a particular form of leukemia or cancer of the bone marrow, which can be treated with targeted imatinib. However, in some cases this medicine has no effect. Researchers at the VIB Vesalius Research Centre, K.U. Leuven, under the direction of Peter Carmeliet, have investigated the role of placental growth factor (PlGF) in mice with CML. Blocking this growth factor increases the life expectancy of these mice, even in those resistant to imatinib.

Chronic myeloid leukemia (CML)

In our body, white blood cells combat foreign intruders, such as viruses and bacteria. In chronic myeloid leukemia, the formation of granulocytes, a particular type of white blood cells, is disturbed. The cells in the bone marrow which should grow into white blood cells show an uncontrolled increase in numbers as a result of a disruption in the maturing process. This uncontrolled growth may damage various tissues and adversely affect the production of normal blood cells in the bone marrow. A shortage of white blood cells makes patients more susceptible to infection.

The Philadelphia chromosome and imatinib

Under normal circumstances, our body very accurately regulates the production of white blood cells. This process is triggered by targeted activation of tyrosine kinase. In most forms of CML, a deviant chromosome is present - the Philadelphia chromosome - which gives rise to BCR-ABL1 fusion kinase. This kinase causes the trouble, leading to the increase in CML cells. Existing medicines (imatinib) therefore target this kinase.

While the effect of imatinib in CML patients is usually quite favorable, the use of imatinib is often not sufficient to remove the diseased cells from the body. Sometimes the disease is already too advanced at the start of treatment, or there is resistance.

Placental growth factor

Researchers from the team headed by Peter Carmeliet have stu
'/>"/>

Contact: Evy Vierstraete
info@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Attitudes toward end-of-life care: A survey of cancer patients and others in Korea
2. NIH grant for the move toward clinical trials targeting the lysosomal storage disease MPSIIIB
3. U.S. Pushes School Cafeterias Toward Healthier Offerings
4. Toward a vaccine for methamphetamine abuse
5. Negative attitudes toward fat bodies going global, study finds
6. Tiny gems take big step toward battling cancer
7. Top scientists unite to develop global scientific strategy Towards An HIV Cure
8. Toward a fast, simple test for detecting cholera rampaging in 40 countries
9. Major step taken toward an open and shared digital brain atlasing framework
10. Warning about benevolent sexism and mens apparently positive attitudes towards women
11. Early Steps Toward an Alzheimers Blood Test
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... July 29, 2014 "Acceptance, Recognition, and ... who faced his own demons and wants other men to ... life partner left. A month later, he had no job, ... pay. When Raymond approached the government for assistance, the emotional ... two-year counselling program. But this approach didn’t get to the ...
(Date:7/29/2014)... 29, 2014 The Cottages Investment ... Cottages at MeadowLands Memory Care, to break ground July ... suffering from memory loss and forms of dementia, Wade ... the development of Oconto Fall’s first assisted living facility ... of The Cottages Investment Group, LLC will license the ...
(Date:7/29/2014)... Tucson-based company Outski has ... or health and wellness program, called 401(play)™. A 401(play)™ ... effective way for employees to use their earned vacation ... employees specify the amount of each paycheck to be ... benefits from offering a 401(play)™ plan to in several ...
(Date:7/29/2014)... In his latest blog post at http://www.perwickstrom.com ... Wickstrom has listed 6 ways to light the “fire” in ... avoid complacency, but for some it’s a losing battle,” commented ... powerful ways to help employees get to the next level; ... whole.” , According to Per Wickstrom, 6 ways to light ...
(Date:7/29/2014)... July 29, 2014 Launched in 2012 ... surpassed 20,000 hangovers earlier this year at its ... for expansion and the publication of research data related ... medical practice. , The only licensed medical practice dedicated ... Heaven launched in 2012 and treated thousands of patients ...
Breaking Medicine News(10 mins):Health News:SBPRA Announces the Release of Its Newest Title, "Acceptance, Recognition, and Control (A.R.C.) Against Depression" 2Health News:The Cottages Investment Group Announces Third Development Project, The Cottages at MeadowLands Memory Care, Oconto Falls 2Health News:The Cottages Investment Group Announces Third Development Project, The Cottages at MeadowLands Memory Care, Oconto Falls 3Health News:The Cottages Investment Group Announces Third Development Project, The Cottages at MeadowLands Memory Care, Oconto Falls 4Health News:Outski launches 401(play)™ Plan to Employers as Part of an Employee Benefit / Health and Wellness Program 2Health News:Per Wickstrom’s Latest Blog Post Lists 6 Ways to Light the “Fire” in Employees 2Health News:Hangover Heaven Surpasses 20,000 Hangovers 2Health News:Hangover Heaven Surpasses 20,000 Hangovers 3
... majorities of older Americans experience significant and troubling gaps ... survey, "How Does It Feel? The Older Adult Health ... Foundation, a champion for improved geriatric care and longtime ... New York University,s College of Nursing. The poll ...
... Houston, TX - Accelerated partial breast irradiation (APBI) ... increasingly popular as a treatment choice for women ... rate of later mastectomy, increased radiation-related toxicities and ... (WBI), according to researchers from The University of ...
... Taking fish-oil supplements does not significantly lower the failure rate ... The study included about 200 North American kidney-failure patients with ... which provides access to the bloodstream for hemodialysis, a process ... The patients were randomly assigned to take fish-oil capsules or ...
... would get a better bang for its health-care buck in ... more in eliminating socio-environmental risk factors than in developing medicines. ... in Children: Elevating the Role of Environment, a new paper ... in the May issue of the Future of the ...
... testing older patients, blood vitamin D levels, there,s uncertainty ... not enough. The threshold amount has become controversial as ... resolve this debate, University of Washington researchers conducted an ... D must be circulating in the blood to lower ...
... parents of teenagers, friends can have as much effect ... according to prevention researchers. "Among friendship groups with ... parents are consistent and aware of your whereabouts, and ... their (children,s) whereabouts, then you are less likely to ...
Cached Medicine News:Health News:National poll: Low cost, lifesaving services missing from most older patients' health care 2Health News:National poll: Low cost, lifesaving services missing from most older patients' health care 3Health News:APBI associated with more mastectomies, toxicities, complications, compared to traditional radiation 2Health News:APBI associated with more mastectomies, toxicities, complications, compared to traditional radiation 3Health News:Fish Oil Doesn't Cut Failure Rate of Hemodialysis Grafts 2Health News:Environment key to preventing childhood disabilities 2Health News:Researchers determine vitamin D blood level for reducing major medical risks in older adults 2Health News:It takes a village to keep teens substance free 2
(Date:7/28/2014)... 2014  Syneron Medical Ltd. (NASDAQ: ELOS ... that its new PicoWay® device has received CE Mark ... and pigmented lesions on any skin type. PicoWay is ... and 1064nm wavelengths, which utilizes Syneron,s proprietary PicoWay technology ... are trillionths of a second, known as picosecond pulses. ...
(Date:7/28/2014)... Concord Medical Services Holdings Limited ("Concord Medical" ... leading specialty hospital management solution provider and operator of ... in China , today announced that ... a special cash dividend of US$0.30 per ordinary share ... Company,s outstanding ordinary shares. The total expense for the ...
(Date:7/28/2014)...   Cardioxyl Pharmaceuticals, Inc. announced today the ... a novel potential treatment for acute decompensated heart failure ... has now initiated dosing of hospitalized patients with decompensated ... to further evaluate the drug,s safety and tolerability as ... I clinical trial evaluated the safety and tolerability of ...
Breaking Medicine Technology:Syneron Announces CE Mark for PicoWay Dual Wavelength Picosecond Laser for Tattoo Removal and Treatment of Pigmented Lesions 2Syneron Announces CE Mark for PicoWay Dual Wavelength Picosecond Laser for Tattoo Removal and Treatment of Pigmented Lesions 3Syneron Announces CE Mark for PicoWay Dual Wavelength Picosecond Laser for Tattoo Removal and Treatment of Pigmented Lesions 4Concord Medical Declares Special Dividend 2Cardioxyl Pharmaceuticals Successfully Completes First Clinical Trial For Heart Failure Drug CXL-1427 2
... plc (Nasdaq: JAZZ ) today announced that the ... Monday, February 27, 2011 at 4:30 p.m. EST/9:30 p.m. GMT. ... and review fourth quarter and full year 2011 financial results. ... accessed from the Investors section of the Jazz Pharmaceuticals, website ...
... PLEASANTON, Calif., Feb. 14, 2012  Thoratec Corporation (NASDAQ: ... circulatory support therapies to save, support and restore failing ... Leerink Swann 2012 Global Healthcare Conference on Thursday, February ... Investor Relations and Business Development, will provide an update ...
Cached Medicine Technology:
The Biopro Cox comb cup is manufactured from titanium and is porous coated on the outside of the shell. The Cox comb cup accommodates a polyethylene insert....
The Plasmacup SC satisfies two important requirements: high primary stability and a low friction bearing surface....
... The integration of Trabecular Metal ... proven implant design results in a ... not only meets surgeon demands for ... provides a wide variety of shell ...
The cementless BiHAPro cup combines proven concepts with the latest innovations in cementless THR....
Medicine Products: