Navigation Links
TorreyPines Therapeutics Licenses Intellectual Property from Johns Hopkins Related to Novel Uses of Glutamate Receptor Antagonists for Prevention, Treatment of Stroke, Heart Attack
Date:5/1/2008

mmercial prospects for our lead AMPA/kainate receptor antagonists, tezampanel and NGX426. By acting through a different mechanism of action than Plavix(R), aspirin or tPA, our compounds could one day provide a treatment alternative for the more than 1.5 million people affected by stroke or heart attack each year."

Tezampanel, given subcutaneously, and NGX426, given orally, are currently being developed by TorreyPines Therapeutics for the treatment of acute migraine and chronic pain. Tezampanel has also been safely administered intravenously in five positive Phase II studies.

Tezampanel is the first AMPA/kainate-type glutamate receptor antagonist to be studied in clinical trials for chronic pain. Glutamate receptors mediate the functioning of glutamate, an important excitatory neurotransmitter. While normal glutamate production is essential, excess glutamate production, either through injury or disease, can have a range of pathological effects. By acting at both the AMPA and kainate receptor site to competitively block the binding of glutamate, both tezampanel and its oral prodrug, NGX426, have the potential to treat a number of diseases and disorders. These include migraine and other forms of chronic pain such as neuropathic pain, muscle spasticity and rigidity, thrombosis, epilepsy, Parkinson's disease and a condition known as central sensitization, a persistent state of hypersensitivity to pain that is a core component of many pain conditions.

About TorreyPines Therapeutics

TorreyPines Therapeutics, Inc. is a biopharmaceutical company committed to providing patients with better alternatives to existing therapies through the research, development and commercialization of small molecule compounds. The company's goal is to develop versatile product candidates each capable of treating a number of acute and chronic diseases and disorders such as migraine, chronic pain, muscle spasticity and rigidity, xerostomia and cognitive disorders. The c
'/>"/>

SOURCE TorreyPines Therapeutics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Gamma Secretase Modulators Show Promise in Alzheimers Disease Animal Model Efficacy Studies, According to Research Conducted by TorreyPines Therapeutics
2. TorreyPines Therapeutics to Present at BMO Capital Markets Focus on Healthcare Conference
3. TorreyPines Therapeutics to Present at the JMP Securities Healthcare Focus Conference
4. Transition Therapeutics to Present at 2008 Morgan Stanley Global Healthcare Unplugged Conference
5. Duska Therapeutics Plans 505(b)(2) NDA Filing Route for ATPace(TM)
6. Echo Therapeutics and Cato BioVentures Sign Right of First Offer Agreement for Dermatology Products and Transdermal Drug Delivery Technologies
7. CV Therapeutics to Announce 2008 First Quarter Financial Results on Friday, April 25, 2008
8. Precision Therapeutics Adds 8 Million Covered Lives Under Contract
9. Hyperion Therapeutics Elects Lota Zoth to Board of Directors
10. Antisense therapeutics scientist out to pull more big deals
11. Vista Partners Initiates Coverage on Arana Therapeutics (ASX: AAH; AIM: AAHx)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2015)... CA (PRWEB) , ... July 28, 2015 , ... ... of Acute Coronary Syndromes (ACS-Heart Attack, Sudden Death, or Angina), many of whom ... cardiology is the identification of individuals with active yet undetected sub-clinical disease, who ...
(Date:7/28/2015)... ... July 28, 2015 , ... Coco Libre announced today ... Award for the Nutrition Beverage category. Established by NCW Magazine, the Awards recognize ... stand out for their social and environmental sustainability. , “This award is great ...
(Date:7/28/2015)... ... ... PeopleKeys today announced that their partner, Celtic Healthcare CEO ... the Year award. The award recognizes the important strides Burchianti and Celtic Healthcare ... have done in incorporating new technology, processes, and procedures into their homecare, hospice, ...
(Date:7/28/2015)... ... July 28, 2015 , ... VAZATA, a ... expanding their cloud presence to support their rapidly growing business. , Headquarted in ... been serving the Dallas/Fort Worth area for almost 50 years. HeartPlace is recognized ...
(Date:7/28/2015)... ... ... the 5th Annual Step for Hope 5K Run/Walk on Saturday, September 12, 2015 ... Stream. All are welcome. , Now in its 5th year, the Step for Hope ... families affected by a brain aneurysm. , “We look forward to you joining us ...
Breaking Medicine News(10 mins):Health News:Utility of a novel coronary artery disease biomarker algorithm in modifying physician adherence to guideline therapy presented at 20th World Congress on Heart Disease 2Health News:Coco Libre Wins 2015 NCW Eco-Excellence Award 2Health News:Receiving Recognition for Compassionate Care and Innovative Processes: Celtic Healthcare CEO Arnie Burchianti Wins Regional EY Entrepreneur of the Year Award 2Health News:Receiving Recognition for Compassionate Care and Innovative Processes: Celtic Healthcare CEO Arnie Burchianti Wins Regional EY Entrepreneur of the Year Award 3Health News:HeartPlace Announces Cloud Expansion with VAZATA 2Health News:HeartPlace Announces Cloud Expansion with VAZATA 3Health News:5th Annual Step for Hope 5K Run/Walk Event in Carol Stream, IL to Benefit Renowned Brain Aneurysm Foundation 2
... 5 The following is a statement by ... commends Reps. Bart Stupak (D-Mich.) and Candice Miller ... (H.R. 903), a bill that would bolster America,s ... attacks by taking advantage of the extensive education, ...
... U.S. Conference of Catholic Bishops (USCCB) has launched ... widely-supported pro-life policies and to oppose the federal ... 24-25, the campaign is being coordinated through the ... Human Life Amendment (NCHLA).To date, tens of millions ...
... Cold Spring Harbor, N.Y. Before a cell can divide ... packed in its chromosomes. The two new sets of chromosomes ... distributed to the resulting "daughter" cells, so that both daughter ... , During cell division, a cellular organ called the ...
... Tenn., Feb. 5 /PRNewswire/ -- As the ... healthcare industry, Quorum Health Resources (QHR) has announced the ... owned QHR subsidiary that provides hospitals and health systems ... face. The challenges are great, according to the American ...
... able to compete globally in tomorrow,s economy, and may ... result of the recent federal budget, states an editorial ... . Health researchers and clinicians, institutions and others must ... of the many medical and scientific advancements discovered in ...
... Directors of,Hawkins, Inc. (Nasdaq: HWKN ), at its ... $0.26 per share payable April 3, 2009, to,shareholders of record ... This is,the 24th consecutive year the Company has paid cash ... Hawkins, Inc. provides a full range ...
Cached Medicine News:Health News:Statement by ADA President John S. Findley on the Dental Emergency Responder Act Introduced Today by Reps. Stupak and Miller 2Health News:Massive Nationwide Pro-Life Postcard Campaign Underway 2Health News:CSHL scientists discover link between control of chromosome duplication and segregation 2Health News:CSHL scientists discover link between control of chromosome duplication and segregation 3Health News:Intensive Resource Group (IRG) Helps Hospitals Address Financial and Operational Crisis 2Health News:Intensive Resource Group (IRG) Helps Hospitals Address Financial and Operational Crisis 3
(Date:7/28/2015)... , July 28, 2015 ... new research report with market overview, trends, ... forecast, porter analysis, recent developments, competitive scenario ... Global Industry Insight: Human Insulin Market Development ...      (Logo: http://photos.prnewswire.com/prnh/20150727/756778) Explore more ...
(Date:7/28/2015)... LINCOLNSHIRE, Ill. , July 28, 2015 ... acumen on par with their levels of clinical excellence. ... (AACC) Annual Meeting & Clinical Lab Expo, Sysmex is ... deliver a comprehensive and intuitive ecosystem that will help ... four key areas, Sysmex aims to add even more ...
(Date:7/28/2015)... July 28, 2015 Rigel Pharmaceuticals, Inc. (Nasdaq: ... report its second quarter 2015 financial results after market ... management will follow the announcement with a live ... (1:30pm Pacific Time) to discuss the financial results. ... call by dialing 855-892-1489 (domestic) or 720-634-2939 (international) ...
Breaking Medicine Technology:Global Human Insulin Market (Size of $24 billion in 2014) to Witness 13% CAGR During 2015 - 2020 2Global Human Insulin Market (Size of $24 billion in 2014) to Witness 13% CAGR During 2015 - 2020 3Global Human Insulin Market (Size of $24 billion in 2014) to Witness 13% CAGR During 2015 - 2020 4Global Human Insulin Market (Size of $24 billion in 2014) to Witness 13% CAGR During 2015 - 2020 5Sysmex Moves Beyond a Better Box 2Sysmex Moves Beyond a Better Box 3Sysmex Moves Beyond a Better Box 4Rigel Announces Conference Call and Webcast to Report Second Quarter 2015 Financial Results 2
Therapeutic Drug Calibrator Series...
The IRN method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of iron in serum....
The AST method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of aspartate aminotransferase activity in serum or plasma...
For the quantitative in vitro determination of Aspartate Aminotransferase (AST) in serum and plasma....
Medicine Products: