Navigation Links
TorreyPines Therapeutics Licenses Intellectual Property from Johns Hopkins Related to Novel Uses of Glutamate Receptor Antagonists for Prevention, Treatment of Stroke, Heart Attack
Date:5/1/2008

mmercial prospects for our lead AMPA/kainate receptor antagonists, tezampanel and NGX426. By acting through a different mechanism of action than Plavix(R), aspirin or tPA, our compounds could one day provide a treatment alternative for the more than 1.5 million people affected by stroke or heart attack each year."

Tezampanel, given subcutaneously, and NGX426, given orally, are currently being developed by TorreyPines Therapeutics for the treatment of acute migraine and chronic pain. Tezampanel has also been safely administered intravenously in five positive Phase II studies.

Tezampanel is the first AMPA/kainate-type glutamate receptor antagonist to be studied in clinical trials for chronic pain. Glutamate receptors mediate the functioning of glutamate, an important excitatory neurotransmitter. While normal glutamate production is essential, excess glutamate production, either through injury or disease, can have a range of pathological effects. By acting at both the AMPA and kainate receptor site to competitively block the binding of glutamate, both tezampanel and its oral prodrug, NGX426, have the potential to treat a number of diseases and disorders. These include migraine and other forms of chronic pain such as neuropathic pain, muscle spasticity and rigidity, thrombosis, epilepsy, Parkinson's disease and a condition known as central sensitization, a persistent state of hypersensitivity to pain that is a core component of many pain conditions.

About TorreyPines Therapeutics

TorreyPines Therapeutics, Inc. is a biopharmaceutical company committed to providing patients with better alternatives to existing therapies through the research, development and commercialization of small molecule compounds. The company's goal is to develop versatile product candidates each capable of treating a number of acute and chronic diseases and disorders such as migraine, chronic pain, muscle spasticity and rigidity, xerostomia and cognitive disorders. The c
'/>"/>

SOURCE TorreyPines Therapeutics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Gamma Secretase Modulators Show Promise in Alzheimers Disease Animal Model Efficacy Studies, According to Research Conducted by TorreyPines Therapeutics
2. TorreyPines Therapeutics to Present at BMO Capital Markets Focus on Healthcare Conference
3. TorreyPines Therapeutics to Present at the JMP Securities Healthcare Focus Conference
4. Transition Therapeutics to Present at 2008 Morgan Stanley Global Healthcare Unplugged Conference
5. Duska Therapeutics Plans 505(b)(2) NDA Filing Route for ATPace(TM)
6. Echo Therapeutics and Cato BioVentures Sign Right of First Offer Agreement for Dermatology Products and Transdermal Drug Delivery Technologies
7. CV Therapeutics to Announce 2008 First Quarter Financial Results on Friday, April 25, 2008
8. Precision Therapeutics Adds 8 Million Covered Lives Under Contract
9. Hyperion Therapeutics Elects Lota Zoth to Board of Directors
10. Antisense therapeutics scientist out to pull more big deals
11. Vista Partners Initiates Coverage on Arana Therapeutics (ASX: AAH; AIM: AAHx)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2015)... On June 22, 2015, Medicare will ... sensitivity (pharmacogenetic) testing that it has reimbursed since 2009. ... 19 million of the 49 million Medicare beneficiaries in the ... adverse drug events.(1) Sadly, if it became a standard of ... the use of an individual’s genetic information to tailor treatment, ...
(Date:6/3/2015)... 2015 Horizon Blue Cross Blue Shield of ... one of the nation’s top employers for diverse managers and ... its national list of Best Places for Diverse Managers and ... 1 Regional Company. This is the sixth consecutive year ... for its diverse workplace policies and programs. , Companies are ...
(Date:6/3/2015)... A group of nine authors involved with TransCelerate ... Award at DIA’s upcoming Annual Meeting. DIA’s Global Inspire ... leadership, level of excellence, and commitment to service on ... the Author(s) of the Year Award, which acknowledges an ... a significant impact in advancing medical product development, published ...
(Date:6/3/2015)... Visual BI Solutions, a leader in ... launch of the second release of its successful ... Studio. The Design Studio EXtension suite allows customers ... into their dashboarding projects. , With the second ... adding key components for customers that are looking ...
(Date:6/3/2015)... 2015 Sitting at a computer for ... the back, neck, shoulders and/or wrists. This can lead ... addition, recent research links sitting for long periods as ... Fortunately, three inventors from Oakville, Ontario, are offering an ... , They have developed a prototype for a patent-pending ...
Breaking Medicine News(10 mins):Health News:Medicare Limiting Coverage Benefit for Drug Sensitivity Testing on June 22, 2015 2Health News:Medicare Limiting Coverage Benefit for Drug Sensitivity Testing on June 22, 2015 3Health News:Medicare Limiting Coverage Benefit for Drug Sensitivity Testing on June 22, 2015 4Health News:Medicare Limiting Coverage Benefit for Drug Sensitivity Testing on June 22, 2015 5Health News:Medicare Limiting Coverage Benefit for Drug Sensitivity Testing on June 22, 2015 6Health News:Medicare Limiting Coverage Benefit for Drug Sensitivity Testing on June 22, 2015 7Health News:Horizon Blue Cross Blue Shield of New Jersey Named a 2015 Best Place for Diverse Managers and Women to Work by Diversity MBA Magazine 2Health News:Authors Representing TransCelerate BioPharma Inc. to Be Honored with Global Inspire Award at DIA’s 2015 51st Annual Meeting 2Health News:Authors Representing TransCelerate BioPharma Inc. to Be Honored with Global Inspire Award at DIA’s 2015 51st Annual Meeting 3Health News:Authors Representing TransCelerate BioPharma Inc. to Be Honored with Global Inspire Award at DIA’s 2015 51st Annual Meeting 4Health News:Visual BI Launches Second Release for its Design Studio EXtensions (DSX) for SAP® BusinessObjects™ Design Studio 2Health News:Visual BI Launches Second Release for its Design Studio EXtensions (DSX) for SAP® BusinessObjects™ Design Studio 3Health News:Adjustable Height Tabletop Unit Invented by Three InventHelp® Clients (TOR-9278) 2
... CHICAGO --- When people finish treatment for cancer, they want ... as possible. But a new Northwestern Medicine study -- one ... survivors still suffer moderate to severe problems with pain, fatigue, ... has ended. "We were surprised to see how prevalent ...
... which is the most lethal type of skin cancer, the results ... the immune-boosting drug Interleukin-2 can improve response rate and progression-free survival. ... the June 2 issue of New England Journal of Medicine ... and one of the first in all cancers to show clinical ...
... and Infectious Diseases (NIAID), part of the National Institutes of ... HIV shut down, and how they can be reactivated. ... proteins that the immune system can use, like the gas ... cell or to damp down its activity. However, in people ...
... , FRIDAY, June 3 (HealthDay News) -- A new ... (MRSA) has been detected in cows, milk in ... Holmes, of the department of veterinary medicine at the ... that this new variant, which is genetically different than ...
... in San Diego from 12-16 June for an annual ... arts--including, this year, a focus on mummies. The ... tsunamis and storm surges; the changing dynamics of Antarctic ... and the intersection of science with music, literature, and ...
... the AIDS epidemic, a once-rare form of cancer known as ... Its stigma was best illustrated by Tom Hanks, who portrayed ... from his co-workers in the 1993 movie "Philadelphia." A ... young virologist searching for a postdoctoral position. He found one, ...
Cached Medicine News:Health News:Cancer survivors can't shake pain, fatigue, insomnia, foggy brain 2Health News:Cancer survivors can't shake pain, fatigue, insomnia, foggy brain 3Health News:Vaccine first to show improved survival rates for metastatic melanoma 2Health News:Vaccine first to show improved survival rates for metastatic melanoma 3Health News:AAAS Pacific Division to convene joint session with world mummy scholars in San Diego 2Health News:AAAS Pacific Division to convene joint session with world mummy scholars in San Diego 3Health News:FSU scientist leads research on AIDS-related cancer 2Health News:FSU scientist leads research on AIDS-related cancer 3
(Date:6/3/2015)... China South 2015 came to a successful conclusion on April ... South has been recognized by industry insiders through its professional ... the medical device manufacturing industry in Southern China ... the successful return of the MEDTEC brand to Shenzhen ... in 2005. , The ...
(Date:6/3/2015)... 2015 Genoa has ... together two pharmacy organizations with proven track records for ... have strong reputations for outstanding customer service, flexibility and ... Genoa is the leading provider of ... those affiliated with managing the cost and quality of ...
(Date:6/3/2015)... 02, 2015 Research and Markets  ( http://www.researchandmarkets.com/research/dg23tb/global ... Pharmaceutical Packaging Market 2015-2019" report to their offering. ... at a CAGR of 5.9% over the period 2014-2019. ... market is the rise in demand for vials and ... second highest growth among all the segments at a ...
Breaking Medicine Technology:MEDTEC Successfully Returns to Southern China 2MEDTEC Successfully Returns to Southern China 3Genoa, a QoL Healthcare Company Acquires Northeast Pharmaceuticals, Inc. 2Global Pharmaceutical Packaging Market 2015-2019 with Amcor, Bemis Healthcare Packaging, Gerresheimer, MeadWestvaco, Owens-Illinois & West Pharmaceutical Services Dominating 2
The Accucount 2000 is designed to automatically count microscopic objects in a field displaying totals on a highly visible digital readout....
... Accelerated Bacterial Enumeration System. Bacterial concentration is ... found by the volume dispensed in the ... decreasing volume of sample is dispensed on ... in an Archimedes spiral. The volume is ...
... analyses the Petri dishes and counts the ... reproducible results. A CCD camera positioned above ... a dedicated computer. The counting alogrithms enable ... compensate for spreading and confluent colonies. The ...
... Gas Monitoring System provides a ... measurements of pH, pCO2, pO2 ... artery (e.g. radial, femoral or ... of O2 saturation; base-excess and ...
Medicine Products: