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TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results
Date:8/8/2008

- Dr. Neil Kurtz Resigns as President and Chief Executive Officer; Evelyn

Graham Appointed Acting Chief Executive Officer -

LA JOLLA, Calif., Aug. 8 /PRNewswire-FirstCall/ -- TorreyPines Therapeutics, Inc. (Nasdaq: TPTX) today announced that Neil Kurtz, M.D., is resigning as President, Chief Executive Officer and a director of the company effective as of August 31, 2008. Dr. Kurtz is leaving TorreyPines to assume the role of President and Chief Executive Officer with a major healthcare services company. TorreyPines also named his replacement with the appointment of Evelyn Graham as acting Chief Executive Officer. Ms. Graham has been the company's Chief Operating Officer since 2006.

"We thank Neil for his leadership and many contributions to TorreyPines during his tenure as CEO," said Peter Davis, Ph.D., Chairman of the Board of Directors of TorreyPines.

Dr. Davis continued, "We are proud to announce the appointment of Ev as acting CEO. Her extensive drug development experience and detailed understanding of the company make her the perfect fit to lead TorreyPines as we continue to advance our programs through significant regulatory and clinical milestones."

"I look forward to continuing to work with our current management team in this new role to realize the full potential of our promising product candidates," said Ms. Graham. "We are currently preparing for our end of Phase II meeting with the FDA on September 29th during which we will discuss our proposed Phase III migraine program for tezampanel. In addition, we are continuing to advance NGX426, the oral version of tezampanel, having initiated a Phase I clinical trial to evaluate its analgesic effect. We anticipate announcing results from this Pha
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SOURCE TorreyPines Therapeutics, Inc.
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