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Toronto researcher's discovery points to a new treatment avenue for acute myeloid leukemia
Date:7/6/2009

tant to standard chemotherapy and since they survive such therapy, they can eventually cause a recurrence of the disease.

The antibody targets the CD123 protein (IL-3 receptor α chain) on the cancer stem cells that drive cancer growth. The antibody does not appear to affect normal blood cells. On the basis of this experimental work, a Phase I clinical trial has been initiated to test safety and effectiveness in patients.

"The cancer stem cell hypothesis is one of the most exciting ideas in cancer biology, with the potential to truly transform cancer therapy. A major question has been whether agents could be developed that specifically target these cells without affecting normal stem cells," said Dr. Benjamin Neel, Director of the Ontario Cancer Institute. "The work of Drs. Dick and Lock provides the first evidence that such therapies may be possible."


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Contact: Nicole Bodnar
nicole.bodnar@uhn.on.ca
416-946-2846
University Health Network
Source:Eurekalert

Page: 1 2

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