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Toronto XVIV0 Lung Perfusion System allows high-risk lungs to be safely transplanted
Date:4/13/2011

e, safer outcomes after transplantation, and shorter periods of mechanical ventilation and intensive care unit stays for patients, says Dr. Marcelo Cypel, first author of the study, and a surgical fellow in transplant and thoracic surgery who helped to develop the Toronto XVIVO System.

After the development of this system in Toronto, lung transplants centers in the United Kingdom, Austria, and Spain have started to successfully use this system, demonstrating that the procedure is reproducible. Drs. Keshavjee and Cypel estimate that the Toronto XVIVO System could potentially quadruple the number of transplants a year.

Unlike current cooling preservation fluids which inhibit repair processes of the donor lungs, the Toronto XVIVO Lung Perfusion System preserves lungs at normal body temperature, with the lungs kept outside the body in a protective dome. The system continuously pumps a bloodless solution of oxygen, proteins and nutrients into injured donor lungs, mimicking normal physiological conditions. The lungs are treated with anti-inflammatory medications and antibiotics. This makes it possible for the injured cells to begin repairing themselves, and sets the stage for more sophisticated repair techniques to be applied to donor lungs.

"This work opens the door for a variety of molecular or gene-based therapies that could potentially be applied to repair various injuries in donor organs in an accurately targeted fashion, as we have shown in our research, to improve the safety and outcome of transplants," says Dr. Keshavjee.

Amie McGarrity began to feel the full effects of cystic fibrosis at the age of 27. Her weight dropped to 43 kilograms (95 pounds), she coughed incessantly, was out of breath and had to use oxygen every day at all times, suffered from constant chest infections, and was hospitalized for months at a time.

Amie, now 30, received her double lung transplant in 2009, as part of the XVIVO clinical trial.
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Contact: Alex Radkewycz
alexandra.radkewycz@uhn.on.ca
416-340-3895
University Health Network
Source:Eurekalert

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