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Topical treatment may prevent melanoma
Date:4/26/2011

ells. Researchers learned that ISC-4 kills melanoma cells two to five times more effectively than it kills normal cells. In addition, examination of the treated skin showed no obvious damage to skin cells or skin structure, and treated animals did not show signs of major organ-related toxicity. This indicates a potential for use as a topical application.

"ISC-4 prevented melanoma by decreasing Akt3 signaling that led to a three-fold increase in apoptosis rates," Robertson said. "Thus, topical ISC-4 can delay or slow down melanocytic lesion or melanoma development in preclinical models and could impact melanoma incidence rates, if similar results are observed in humans."

Currently, surgical excision is used to remove melanocytic lesions or prevent development into more aggressive cancer. Topical ISC-4 treatment could potentially be an alternative to surgery for some patients.

"Topical or localized treatments, such as those we propose for ISC-4, could permit the use of high local concentrations with minimal toxicity and be useful for treating cutaneous lesions not amenable to surgical removal or other currently available approaches," Robertson said.

"With more than $1 billion spent on sunscreen every year in the United States, the market for skin cancer prevention is enormous and continues to grow," Robertson said. "Addition of agents such as ISC-4 to sunscreens, body lotions or creams could have a profound impact on this market for preventing melanoma."


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Contact: Matt Solovey
msolovey@hmc.psu.edu
717-531-8606
Penn State
Source:Eurekalert

Page: 1 2

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