imod appeared to improve quality of life as well, as severe itching and pain was lower among treated patients than placebo patients both right after treatment and one year later.
Seters and her colleagues say they still must map out the exact mechanics behind the cream's impact, while exploring why some patients benefited while others did not. Nevertheless, they concluded that the cream should be considered the "first-choice treatment" for these lesions.
However, Debbie Saslow, director of breast and gynecologic cancer at the American Cancer Society in Atlanta, offered a word of caution.
"While it moves the field forward, and it's important and very exciting, they still need larger numbers than this to be able to tell women that this is the new standard of care," she said. "But, of course, if we can ultimately recommend a topical cream for 16 weeks instead of an invasive surgical or laser procedure, that's going to be a big advantage."
For additional details on vulvar cancer treatment, visit the American Cancer Society.
SOURCES: Debbie Saslow, Ph.D., director, breast and gynecologic cancer, American Cancer Society, Atlanta; Manon van Seters, M.D., department of gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands; April 3, 2008, New England Journal of Medicine
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