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Top10 research advances include studies on genetics and stem cell research, stents
Date:12/20/2007

eterans Affairs Office of Research and Development provided support for this study.

  • 7. Generation of functional cardiomyocytes from adult mouse spermatogonial stem cells

    This study analyzed the complex functional properties of cardiomyocytes (heart muscle cells) derived from maGSCs in vitro and the behavior of undifferentiated maGSCs in normal hearts of mice in vivo after transplantation. The authors conclude that maGSCs provide a new source of distinct types of cardiomyocytes for basic research/potential therapeutic application.
    Source: Circulation Research, June 8, 2007; Circ Res. 07 Jun 8;100(11):1615-25; www.ahajournals.org.
    Funding: A grant from the Georg-August-University of Gottingen supported this study.

  • 8. HORIZONS: Harmonizing Outcomes with RevascularIZatiON and Stents

    This large study examined the safety and effectiveness of anticoagulation medications and drug-eluting stents in patients experiencing a STEMI heart attack, in which the coronary artery is completely blocked, without significantly increasing the rate of death or recurrent heart attacks among these patients.
    Source: Late-breaking trial at the Transcatheter Cardiovascular Therapeutics TCT 2007; www.tct2007.com.
    Funding: The Cardiovascular Research Foundation supported this study.

  • 9. Effectiveness and safety of drug-eluting stents in Ontario

    This large Canadian study found that drug-eluting stents are effective in reducing the need for target-vessel coronary artery bypass in patients at the highest risk for re-narrowing of previously blocked arteries, without a significantly increased rate of death or heart attack.
    Source: New England Journal of Medicine, Oct. 7, 2007; N Eng J Med 2007; 14;357:1393-1402; www.nejm.org.
    Funding: The Ontario Ministry of Health and Long-Term
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Contact: Cathy Lewis
cathy.lewis@heart.org
214-706-1324
American Heart Association
Source:Eurekalert

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