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Top research highlighted in fight against heart disease and stroke
Date:12/21/2010

can Heart Association. These findings are the first to show that participating in a quality improvement program, such as Get With The GuidelinesCoronary Artery Disease, can eliminate racial and ethnic disparities of care while increasing the overall use of evidence-based care for heart attack patients.
  • Cohen et al Circulation, June 1, 2010; Circulation;121(21):2294-301; http://circ.ahajournals.org; Funding: GWTG-CAD is supported by the American Heart Association in part through an unrestricted education grant from Merck/Schering-Plough Partnership.

Top Ten Advances in Stroke Research in 2010

1. "Time is brain": Clot-dissolving treatment for acute ischemic stroke found beneficial in the first 4.5 hours after onset, potentially harmful later

A combined patient analysis of eight trials of intravenous tissue plasminogen activator (tPA) for acute ischemic stroke reinforced prior findings of a strong time-to-treatment effect, with greatest benefit in the first few hours after onset, and, for the first time, demonstrated increased mortality from late treatment beyond 4.5 6 hours after onset.

  • Pooled analysis of the ECASS, ATLANTIS, NINDS and EPITHET trials Lancet, May 15, 2010; www.thelancet.com; Lancet 2010;375(9727):1695-703; Funding: There was no funding source for this study.

2. New mechanism of emboli clearance from the brain vasculature discovered

This study identified an entirely new way by which brain blood vessels are kept open by the body in the face of clots extravasation. Clots that are not able to be dissolved are sometimes pushed out through blood vessel walls into the surrounding tissue, restoring nourishing flow in blood vessels.

  • Lam, et al; Nature, May 27, 2010; www.nature.com. Nature 2010;465:478-482; Funding: No funding sources were listed.

3. Carotid endarterectom
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Contact: Corporate & Media Communications
cathy.lewis@heart.org
214-706-1396
American Heart Association
Source:Eurekalert

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