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Top research highlighted in fight against heart disease and stroke
Date:12/21/2010

12, 2010; N Engl J Med;363:36-44; www.nejm.org; Funding: Cameron Health.

6. Hopeful new procedure for infants with congenital heart disease

The Pediatric Heart Network's randomized trial of Norwood shunt types in infants with single-ventricle lesions showed that the type of shunt used makes a difference in outcomes. Better transplantation-free survival at 12 months is a possibility with this new understanding of the better shunt choice for these patients. This was the first large-scale randomized trial in congenital heart surgery, offering an approach that should provide answers to other questions in the future.

  • Pediatric Heart Network Investigators New England Journal of Medicine, May 27, 2010; N Engl J Med; 362:1980-1992. www.nejm.org; Funding: National Heart, Lung, and Blood Institute.

7. Finding the right anti-clotting (anti-platelet) therapy

Selecting the right type of anti-clotting drug and the right dosage can be tricky, and risky. New research from the PLATO investigators has found that ticagrelor may improve outcomes and reduce adverse events better than the current standard, clopidogrel. The CURRENT-OASIS 7 Trial is exploring the optimal dosing of clopidogrel and aspirin in patient undergoing invasive surgery. These studies will help providers better understand the situations where new choices and dosages may improve results for the patient.

  • PLATO Investigators Lancet, Jan. 14, 2010; Lancet 2010;375:283-93. www.thelancet.com; Funding: AstraZeneca.
  • CURRENT-OASIS 7 Investigators New England Journal of Medicine, Sept 2, 2010; N Engl J Med; 363:930-42;. www.nejm.org; Lancet, Sept. 1, 2010; Lancet 2010; 376:1233-43; www.thelancet.com; Funding: Sanofi-Aventis; Bristol-Myers Squibb

8. Basic science findings offer
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Contact: Corporate & Media Communications
cathy.lewis@heart.org
214-706-1396
American Heart Association
Source:Eurekalert

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