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Top research highlighted in fight against heart disease and stroke
Date:12/21/2010

positive findings from the RE-LY trial, the U.S. Food and Drug Administration approved dabigatran for stroke prevention in AF patients. The ROCKET-AF trial presented at the American Heart Association's Scientific Sessions 2010. Rivaroxiban, apixiban, edoxaban and other oral anticoagulants are being or have been studied in AF and may show future promise.
  • RE-LY - Lancet, Sept. 18, 2010; Lancet. 2010 Sep 18;376(9745):975-83; www.thelancet.com. Funding: Boehringer Ingelheim.
  • ROCKET-AF American Heart Association Scientific Sessions 2010, Abstract 21839. Funding: Johnson & Johnson, Bayer HealthCare.
  • AVERROES European Society of Cardiology Congress 2010. Funding: Bristol-Myers Squibb Company, Pfizer.

5. Adjusting pacing therapies can improve outcomes for heart failure patients

Many heart failure patients experience abnormal heart rhythms, known as arrhythmia. There are a number of devices available to treat arrhythmia, including implantable cardioverter difibrillators (ICDs) which can shock the heart beat back into a normal rhythm. New studies show that adding additional resynchronization pacing to ICD therapy can lead to improved outcomes in an expanded group of heart failure patients. In addition, new types of ICDs (defibrillators without leads, for example) can offer options that reduce some of the risks associated with traditional devices.

  • MADIT-CRT Trial Investigators New England Journal of Medicine, Sept. 1, 2009; N Engl J Med;361(14) 1329-1338. www.nejm.org; Funding: Boston Scientific.
  • RAFT Investigators American Heart Association Scientific Sessions 2010, Abstract 21768; New England Journal of Medicine, Nov. 14, 2010. 10.1056/nejmoa1009540; www.nejm.org; Funding: Canadian Institutes of Health Research; Medtronic of Canada.
  • Bardy, et al New England Journal of Medicine, May
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