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Top research highlighted in fight against heart disease and stroke
Date:12/21/2010

rgery or stenting.
  • ACES Lancet Neurology, July 2010; www.thelancet.com; Lancet Neurol;9(7):663-71; Funding: British Heart Foundation.

7. Robot-assisted therapy beneficial for long-term arm impairment after stroke

This randomized trial suggested that robot-assisted therapy can improve the rehabilitation of arm function after stroke compared with ordinary care, though no more than intensive therapist care.

  • Lo, et al New England Journal of Medicine, May 16, 2010; www.nejm.org; N Engl J Med. 2010;362(19):1772-83; Funding: Veterans Affairs Cooperative Studies Program and Rehabilitation Research and Development Service.

8. Genetic findings important in understanding, treating aneurysms

Two new studies looked at the genetics and treatment of aneurysms, balloon-like dilations of arterial walls that can be fatal if they rupture or tear. Saccular intracranial aneurysms are located in the intracranial arterial wall; their hemorrhage commonly results in severe neurologic impairment and death. This multicenter genome-wide association study in Europe and Japan identified three new and confirmed two previously-suspected chromosome sites as harboring genes predisposing to the formation of intracranial aneurysms. Vascular Ehlers-Danlos syndrome is a rare, genetic, severe disease that causes arterial dissections and ruptures that can lead to early death. This randomized trial found that treatment with a beta-blocker medication to lower mechanical stress on arterial walls prevents dissection and hemorrrhages in Ehlers-Danlos patients.

  • Yasuno, et al Nature Genetics, May 2010; www.nature.com; Nat Genet;2010;42(5):420-5; Funding: Yale Center for Human Genetics and Genomics,Yale Program on Neurogenetics, US National Institute of Health, Howard Hughes Medical Institute.
  • Ong, et al Lanc
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