SAN FRANCISCO (March 7, 2013) Poor dental health, especially tooth loss, is associated with several established cardiovascular risk factors, including diabetes, smoking, blood pressure, obesity and other novel risk factors, according to research being presented at the American College of Cardiology's 62nd Annual Scientific Session.
Although several studies have proposed a link between periodontal disease and coronary heart disease, knowledge about periodontal disease in patients with established heart disease is lacking. Researchers investigated the prevalence of self-reported tooth loss and occurrence of gum bleeds, as surrogate markers of periodontal disease, and their relation to cardiovascular risk factors in high-risk patients with coronary heart disease participating in the ongoing STABILITY study, a global clinical trial evaluating the anti-atherosclerosis drug darapladib.
At the start of the study, 15,828 study participants from 39 countries reported their remaining number of teeth, categorized as none, 1-14, 15-19, 20-25 or 26-32, and frequency of gum bleeds, never/rarely, sometimes, often or always. Data on cardiovascular risk factors were also obtained, and statistical analyses were performed, adjusting for age, smoking, diabetes and education. Approximately 40 percent of participants had fewer than 15 teeth and 16 percent had no teeth; 25 percent of subjects reported gum bleeds.
For every decrease in number of teeth, researchers observed increasing levels of Lp-PLA2, an enzyme that increases inflammation and promotes hardening of the arteries, as well as an increase in other cardiac risk markers including LDL or "bad" cholesterol, blood sugar, blood pressure and waist circumference. Participants with fewer teeth also had higher probability of having diabetes, with the odds increasing by 11 percent for every decrease in number of teeth category. Greater loss of teeth was also associated with being a current or former smoke
|Contact: Beth Casteel|
American College of Cardiology