Navigation Links
Too Much Acetaminophen Over Time May Damage Liver
Date:11/22/2011

TUESDAY, Nov. 22 (HealthDay News) -- Taking slightly too much of the pain reliever acetaminophen (best known by the brand name Tylenol) over time can lead to an overdose that can cause liver failure and death, according to a new study.

These "staggered overdoses" can occur when people have ongoing pain and repeatedly take a little more acetaminophen than they should, explained Dr. Kenneth Simpson, author of the study, published Nov. 22 in the British Journal of Clinical Pharmacology.

"They haven't taken the sort of single-moment, one-off massive overdoses taken by people who try to commit suicide, but over time the damage builds up, and the effect can be fatal," Simpson said in a journal news release.

He and his colleagues analyzed data from 663 patients with acetaminophen-induced liver injury who were admitted to the Royal Infirmary of Edinburgh, Scotland between 1992 and 2008. In the U.K. and elsewhere, acetaminophen is known as paracetamol.

Of those patients, 161 had suffered a staggered overdose while taking acetaminophen to relieve a variety of ailments, such as headache, toothache and abdominal and muscular pain.

Compared with people who'd taken a single overdose of acetaminophen, those with a staggered overdose were more likely to have liver and brain problems, require kidney dialysis or help with breathing, and were at greater risk of dying.

Patients with a staggered overdose may not report that they've suffered an overdose when they come to the hospital. They may just report feeling unwell. Doctors need to recognize and treat this situation quickly, Simpson said.

"Staggered overdoses or patients presenting late after an overdose need to be closely monitored and considered for the (acetaminophen) antidote, N-acetylcysteine, irrespective of the concentration of (acetaminophen) in their blood," he said in the release.

More information

The MedlinePlus Medical Encyclopedia has more about acetaminophen overdose.

-- Robert Preidt

SOURCE: British Journal of Clinical Pharmacology, news release, Nov. 22, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Study links acetaminophen to lower prostate cancer risk
2. Drugmakers to End Infant Formulas of Products With Acetaminophen
3. FDA Lowers Amount of Acetaminophen Allowed in Prescription Painkillers
4. Acetaminophen use in adolescents linked to doubled risk of asthma
5. Improved method of electrical stimulation could help treat damaged nerves
6. The serotonin system in womens brains is damaged more readily by alcohol than that in mens brains
7. Stem Cells Show Promise in Healing Damaged Hearts
8. Stem cell research hopes to repair brain damage of Parkinsons disease
9. Scientists prevent cerebral palsy-like brain damage in mice
10. Flexible covering to combat water damage wins 2011 Innovation Prize
11. Protein May Help Spot Newborns With Brain Damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... 2017 , ... Tuesday, March 28, 2017, is the annual American Diabetes Association ... Test to find out if they are at risk for developing Type 2 diabetes. ... evening sky by programming the LAX pylons the color red. Downtown’s U.S. Bank Tower ...
(Date:3/28/2017)... ... March 28, 2017 , ... Revolution for Truth ... Congress to protect parental rights and civil liberties, and to restore transparency within ... The demonstration coincides with a press conference taking place Friday morning calling on ...
(Date:3/28/2017)... (PRWEB) , ... March 28, ... ... a non-profit medical society dedicated to advancing the science and clinical practice ... from its RSSearch Patient Registry, a multi-institutional, observational registry established to standardize ...
(Date:3/28/2017)... ... March 28, 2017 , ... Usually, the impending arrival of warmer ... for those self-conscious about a double chin, this means more anxiety than elation. The ... , “For most people, a double chin is undesirable,” Dr. Goldman said, “but it ...
(Date:3/28/2017)... , ... March 28, 2017 , ... ... announced the release of two biometric time and attendance tracking products: the new ... software. NCheck Cloud Bio Attendance uses biometric face recognition to enable users ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... , March 29, 2017  Designers of primary cell ... solution size by 50% and extend battery life with ... management integrated circuit (PMIC) from Maxim Integrated Products, Inc. ... a low input voltage of just 0.7V for new ... Silver Oxide, as well as the more common Alkaline ...
(Date:3/29/2017)... KALAMAZOO, Michigan , USA, March 29, 2017 /PRNewswire/ ... a Company that Cares by People magazine, in partnership ... out of 50 companies on the list. This list ... employees that have succeeded in business while also demonstrating ... and the environment.  To determine the ...
(Date:3/29/2017)... , March 29, 2017 /PRNewswire/ - Medicure Inc. ... release financial results for the year ended December ... 26, 2017. The results are being released later ... financial statements will include the operations and balances ... 1, 2016.  This release and filing date meets ...
Breaking Medicine Technology: