Navigation Links
Tomato Diet Can't Guarantee Prostate Health: Study
Date:9/14/2007

Lycopene, other nutrients no shield against prostate cancer, researchers say

FRIDAY, Sept. 14 (HealthDay News) -- Men who've been adding vitamin E or the tomato nutrient lycopene to their diets to cut their risk of prostate cancer may need to think again.

According to a new study, neither carotenoids (such as lycopene), retinol, nor tocopherols (forms of vitamin E) appear to reduce the odds of prostate malignancy -- findings that are in line with two other recent publications.

"Our overall findings are null," said lead researcher Timothy Key, deputy director of the Cancer Research UK Epidemiology Unit at the University of Oxford, U.K.

"This large study does not support the hypothesis that consuming large amounts of these nutrients will reduce prostate cancer," he added. "That is disappointing, but that is the overall message."

The findings are published in the September issue of the American Journal of Clinical Nutrition.

His team examined the effect of the blood levels of 10 micronutrients on the risk of developing prostate cancer for almost 2,000 males from eight European countries.

The research, which the authors call "the largest prospective study to date of plasma carotenoids, retinol, tocopherols, and prostate cancer risk," was part of the EPIC (European Prospective Investigation into Cancer and Nutrition) study, which includes more than half a million men and women.

The authors did find evidence to suggest that, once a cancer forms, high levels of lycopene (or of carotenoids in general, including lycopene) may reduce by about 60 percent the risk of the tumor progressing to an advanced-stage prostate cancer. Carotenoids appeared to have no effect on the rate of localized, earlier-stage disease, however.

According to Dr. Peter Scardino, head of the Prostate Cancer Program at Memorial Sloan-Kettering Cancer Center in New York City, prostate cancer is the most common cancer in men in the developed world. A Western male, he said, has about a 42 percent risk of developing cancerous cells in his prostate over his lifetime, a 16 percent risk of being diagnosed with the disease, and about a three percent risk of dying as a result. In other words, nearly one-quarter of Western males have a subclinical form of prostate cancer, which will never progress to more advanced disease.

Stopping progression is crucial. According to Scardino, for those whose disease does progress, the risk of death is much higher -- nearly 50 percent.

"I think it's an important study," Scardino said. That lycopene and bulk carotenoids reduced the risk of progressing to advanced disease without impacting the risk of developing prostate cancer overall, he said, "suggests maybe these micronutrients are not as important in [stopping] carcinogenesis as they are in [slowing] progression of a very small early tumor to one that becomes invasive and larger and develops the ability to metastasize."

"The study provides supportive evidence that lycopene and the carotenoids may have an effect on delaying the progression of prostate cancer, so, from that point of view, it is an interesting study," Scardino added.

But Alan Kristal, associate head of the Cancer Prevention Program at the Fred Hutchinson Cancer Research Center in Seattle, remained more skeptical. Though he called the study "well-executed," Kristal noted, for instance, that the authors were unable to control for prostate-specific antigen (PSA) testing among the men. These blood tests often detect clinically irrelevant tumors, he explained.

"You can never do an observational study of prostate cancer without rigorously controlling for whether or not the person got PSA screening," Kristal said. "The more times you take the test, the more likely you are to get the disease."

He also noted that the finding for lycopene contradicts a report published in May in Cancer Epidemiology Biomarkers and Prevention. That study did account for PSA testing, and it found no effect of lycopene whatsoever on prostate cancer risk -- including the risk of advanced disease.

"To my mind, that study is definitive," said Kristal. "It's a big study, extremely well executed, properly analyzed, and not biased by PSA screening."

A review of lycopene's effect on cancer by the U.S. Food and Drug Administration, published in July in the Journal of the National Cancer Institute, likewise found "no credible evidence to support an association between lycopene intake and a reduced risk of prostate, lung, colorectal, gastric, breast, ovarian, endometrial, or pancreatic cancer and very limited evidence to support an association between tomato consumption and reduced risks of prostate, ovarian, gastric, and pancreatic cancers," according to that study's authors.

So, with tomatoes, ketchup and pizza sauce crossed off the list of prostate-protecting foods, Key and others continue the search. Kristal, for instance, is on the executive committee of a randomized trial examining the effects of selenium and/or vitamin E on prostate cancer risk in 35,000 men. Results are expected in 2012, he said.

Said Key, "I am optimistic we will find something. This paper is an important piece of work, but it doesn't look like this is the answer."

More information

For more on vitamins and cancer, visit the American Cancer Society.



SOURCES: Tim Key, Ph.D., deputy director, Cancer Research UK Epidemiology Unit, University of Oxford, U.K.; Peter Scardino, M.D., chairman, department of surgery and head, Prostate Cancer Program, Memorial Sloan-Kettering Cancer Center, New York City; Alan Kristal, DrPH, member and associate head, Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle; September 2007, American Journal of Clinical Nutrition


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Protective effects of tomatoes in prostate cancer
2. Tomatoes for the heart
3. Tomato Sauce reduces Cancer Risk- Study
4. A Tomato a Day Keeps Heart Disease Away
5. Tomatoes Might Inhibit the Development Of Prostate Cancer
6. Hearty tomatoes
7. Tomato Extract Found To Reduce The Risk Of Thrombosis
8. The juice of our very own tomato might be helpful in protecting lungs
9. Roma tomatoes the culprits for salmonella infection
10. Tomato: The Vaccine Plant, Against Bird Flu
11. Raspberries Are Richer In Anti-Oxidants Than Tomatoes Or Broccoli
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... January 17, 2017 , ... ... companies and ranked among the top US security companies for consecutive years, today ... This announcement brings a year-long independent board nomination process to a close and ...
(Date:1/17/2017)... (PRWEB) , ... January 17, 2017 , ... ... Center and the Montclair State University’s Athletic Training Education program forged a relationship ... Athletic Training Education Program, which is consists of both student members and ...
(Date:1/16/2017)... ... ... California Southern University has named Dr. Steven Beazley University President. ... a core faculty member, teaching master’s and doctoral courses in the university’s School of ... where he earned his Doctor of Psychology degree in 1998. Dr. Beazley also has ...
(Date:1/16/2017)... ... January 16, 2017 , ... With the Grand Opening Event planned for ... use by sports teams and the general public. Built in five months by Centerpoint, ... be converted into basketball or pickleball courts. The space is also suitable for indoor ...
(Date:1/16/2017)... ... January 16, 2017 , ... As New York’s ... Victor Giamos, MD to their medical staff, according to eye surgeon, Jeffrey Martin, ... Eye Care, a division of SightMD. Dr. Giamos will practice primarily out of ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... Calif. and KANSAS CITY, ... Children,s Hospitals Neonatal Consortium (CHNC) has selected Velos ... their visionary data management and multicenter initiatives. ... organization comprised of 32 Neonatal Intensive Care Units ... America . The consortium provides a benchmark ...
(Date:1/17/2017)... , Jan. 17, 2016  Attorney Advertising -- Bronstein, Gewirtz ... purchasers of Anthera Pharmaceuticals, Inc. ("Anthera" or the "Company") (NASDAQ: ... additional information and assist the investigation by visiting the firm,s ... Anthera and certain of its officers and/or directors have violated ... 1934. ...
(Date:1/17/2017)...   Tocagen Inc ., a clinical-stage, cancer-selective gene therapy company, ... research and pharmaceutical development at Tocagen, will present at Phacilitate ... 17-20 in Miami . Details ... ... replicating viruses - what to do when and why Date and ...
Breaking Medicine Technology: