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Toll-like receptors play role in brain damage in newborns
Date:11/23/2011

making the brain more sensitive to hypoxia, resulting in worse brain damage," Stridh explains. "If these signals are blocked, the degree of brain damage is reduced."

Barrier opened

In her thesis, Stridh also looks at a protein called occludin, which has the role of gluing together cells in the blood-brain barrier.

"Our results show that there is a reduction in occludin at a genetic level following infection," she explains. "This can lead to the opening of the barrier, making it easier for inflammatory molecules and cells in the blood to get into the brain and cause inflammation."


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Contact: Linnea Stridh
linnea.stridh@neuro.gu.se
46-031-786-3377
University of Gothenburg
Source:Eurekalert  

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Toll-like receptors play role in brain damage in newborns
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