Navigation Links
Toll-like receptors play role in brain damage in newborns

Two out of every thousand babies are at risk of brain damage in connection with birth. Researchers at the Sahlgrenska Academy at the University of Gothenburg, Sweden, have identified mechanisms behind these injuries, which could lead to better treatment and a richer life for the infants affected. Roughly two in every thousand babies are at risk of suffering brain damage as a result of events before, during and after delivery. Infections in the blood or a reduced supply of oxygen and blood can lead to inflammation in the brain, causing injury. This type of brain damage, which is much more common in premature babies, can result in neurological problems such as cerebral palsy, learning difficulties and epilepsy.

Toll-like receptors

Researchers at the University of Gothenburg's Sahlgrenska Academy have now found that toll-like receptors (TLRs) in the innate immune system play a major role in the state of the brain in newborns. The discovery could lead to better treatment and a richer life for many children.

Key role in the immature brain

Research into TLRs, which was rewarded with this year's Nobel Prize in Physiology or Medicine, has previously shown that these receptors are involved in stroke-related brain damage in adults. The researchers in Gothenburg have now shown that TLRs are also present in the immature brain and play an important role there. "By understanding the role of toll-like receptors in the inflammatory process following brain injury, we hope eventually to find more effective treatment strategies," says Linnea Stridh from the Sahlgrenska Academy, who presents the results in her thesis.

Simulated brain injuries

Stridh and her colleagues used mice in their studies to simulate the brain injuries seen in newborn babies. They found that special TLRs contribute to brain damage following hypoxia, where the brain is starved of oxygen. "An infection can activate these receptors, making the brain more sensitive to hypoxia, resulting in worse brain damage," Stridh explains. "If these signals are blocked, the degree of brain damage is reduced."

Barrier opened

In her thesis, Stridh also looks at a protein called occludin, which has the role of gluing together cells in the blood-brain barrier.

"Our results show that there is a reduction in occludin at a genetic level following infection," she explains. "This can lead to the opening of the barrier, making it easier for inflammatory molecules and cells in the blood to get into the brain and cause inflammation."

Contact: Linnea Stridh
University of Gothenburg

Related medicine news :

1. Folate receptors may serve as a front door to ovarian cancer treatment
2. Nuclear receptors battle it out during metamorphosis in new fruit fly model
3. Historic first images of rod photoreceptors in the living human eye
4. Researchers get a grip on nervous systems receptors
5. Targeting nicotine receptors to treat cognitive impairments in schizophrenia
6. Nuclear receptors reveal possible interventions for cancer, obesity
7. New drug targets vitamin D receptors in hormone resistant prostate cancers
8. Bitter Taste Receptors Found in Lungs May Aid Asthma Patients
9. Cedars-Sinai study: How does a good protein hurt brain cells after clot-induced stroke?
10. Enhanced treatment of brain tumors
11. Meditation Can Turn Off Regions of the Brain
Post Your Comments:
Related Image:
Toll-like receptors play role in brain damage in newborns
(Date:12/1/2015)... ... 01, 2015 , ... Lutronic, a leading innovator of aesthetic and medical laser ... devices for sale in the United States. Clarity is a Superior Dual Wavelength ... lasers, into a single platform that is easy to own and operate. , ...
(Date:12/1/2015)... ... December 01, 2015 , ... With FCPX Overlay: Grit , users can ... customization, the possibilities are truly endless, all with a click of a mouse. Each ... flip, horizontal flip, depth of field and more, all within Final Cut Pro X. ...
(Date:11/30/2015)... ... 2015 , ... Third Molar SEO , one of ... launched a sleek, mobile-ready and user-centric redesigned website. , Vivek Srivastava, founder and ... the benefits that its SEO services provide to dentists and why Third Molar ...
(Date:11/30/2015)... (PRWEB) , ... December 01, 2015 , ... The ... 2015-2016 inductee into its VIP Woman of the Year Circle. She is recognized with ... leading networking organization exclusively for professional women, boasting more than 850,000 members and over ...
(Date:11/30/2015)... ... , ... Until now, the St. Louis Fetal Care Institute used ... Study) trial. One of these exclusion criteria was a BMI above 34.9. According to ... is considered normal, 25 - 29.9 is overweight and above 30 is obese. , ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... Texas , Dec. 1, 2015 /PRNewswire/ ...  announced today that top-line data from its ... telotristat etiprate in treating carcinoid syndrome in ... with the clinical benefit observed in its ... designed as a companion to TELESTAR primarily ...
(Date:12/1/2015)... Colo. , Dec. 1, 2015 Ampio ... New York Stock Exchange has established January 5, 2016 as ... its stockholders of the shares of Common Stock of ... (1) share of Aytu common stock for every five ... the record date, December 1, 2015. The distribution date will ...
(Date:12/1/2015)... PUNE, India , December 1, 2015 ... defines and segments the concerned market with analysis and ... orthobiologics report defines and segments the concerned ... According to the Market Research Report "North American ... Bone Growth Factors & Spinal Stimulation, Stem Cell Therapy, ...
Breaking Medicine Technology: