Navigation Links
Toll-like receptors play role in brain damage in newborns
Date:11/23/2011

Two out of every thousand babies are at risk of brain damage in connection with birth. Researchers at the Sahlgrenska Academy at the University of Gothenburg, Sweden, have identified mechanisms behind these injuries, which could lead to better treatment and a richer life for the infants affected. Roughly two in every thousand babies are at risk of suffering brain damage as a result of events before, during and after delivery. Infections in the blood or a reduced supply of oxygen and blood can lead to inflammation in the brain, causing injury. This type of brain damage, which is much more common in premature babies, can result in neurological problems such as cerebral palsy, learning difficulties and epilepsy.

Toll-like receptors

Researchers at the University of Gothenburg's Sahlgrenska Academy have now found that toll-like receptors (TLRs) in the innate immune system play a major role in the state of the brain in newborns. The discovery could lead to better treatment and a richer life for many children.

Key role in the immature brain

Research into TLRs, which was rewarded with this year's Nobel Prize in Physiology or Medicine, has previously shown that these receptors are involved in stroke-related brain damage in adults. The researchers in Gothenburg have now shown that TLRs are also present in the immature brain and play an important role there. "By understanding the role of toll-like receptors in the inflammatory process following brain injury, we hope eventually to find more effective treatment strategies," says Linnea Stridh from the Sahlgrenska Academy, who presents the results in her thesis.

Simulated brain injuries

Stridh and her colleagues used mice in their studies to simulate the brain injuries seen in newborn babies. They found that special TLRs contribute to brain damage following hypoxia, where the brain is starved of oxygen. "An infection can activate these receptors,
'/>"/>

Contact: Linnea Stridh
linnea.stridh@neuro.gu.se
46-031-786-3377
University of Gothenburg
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Folate receptors may serve as a front door to ovarian cancer treatment
2. Nuclear receptors battle it out during metamorphosis in new fruit fly model
3. Historic first images of rod photoreceptors in the living human eye
4. Researchers get a grip on nervous systems receptors
5. Targeting nicotine receptors to treat cognitive impairments in schizophrenia
6. Nuclear receptors reveal possible interventions for cancer, obesity
7. New drug targets vitamin D receptors in hormone resistant prostate cancers
8. Bitter Taste Receptors Found in Lungs May Aid Asthma Patients
9. Cedars-Sinai study: How does a good protein hurt brain cells after clot-induced stroke?
10. Enhanced treatment of brain tumors
11. Meditation Can Turn Off Regions of the Brain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Toll-like receptors play role in brain damage in newborns
(Date:9/1/2015)... ... September 01, 2015 , ... September is Baby Safety Month, and ... labels and stickers to keep little ones' safety top of mind at all times. ... a particular focus. According to the JPMA's Baby Safety Zone website, this year's theme ...
(Date:9/1/2015)... ... 2015 , ... Curly Hair Solutions™ is thrilled to partner ... partnership between Curly Hair Solutions™ and Trade Secrets allows for nationwide distribution of ... Curly Hair Solutions™ team could not be more delighted to see their line ...
(Date:8/31/2015)... ... 01, 2015 , ... Spinal fusion surgery – which connects ... long, arduous recovery. However, today’s minimally invasive fusions achieve similar results as traditional ... muscle damage. These advantages of minimally invasive surgery redeem the procedure’s reputation, according ...
(Date:8/31/2015)... ... August 31, 2015 , ... ... potential patients the resources they need to have a successful cosmetic procedure; from ... plastic surgeons; Cosmetic Town Journal is always ready to help. , It is ...
(Date:8/31/2015)... ... , ... Southern Vacation Rentals – a member of the locally owned and ... property management company, 360 Blue, in support of the Sonder Project, a global ... two companies will collect any unopened food items left in vacation rentals after guest ...
Breaking Medicine News(10 mins):Health News:Lightning Labels Can Help Make A Difference This Baby Safety Month 2Health News:Lightning Labels Can Help Make A Difference This Baby Safety Month 3Health News:Curly Hair Solutions™ Partners With Trade Secrets 2Health News:Minimally Invasive Spinal Fusions Squash Back Pain without Arduous Recovery 2Health News:Minimally Invasive Spinal Fusions Squash Back Pain without Arduous Recovery 3Health News:Minimally Invasive Spinal Fusions Squash Back Pain without Arduous Recovery 4Health News:Cosmetic Town: A One Stop Plastic Surgery Community 2Health News:Southern Vacation Rentals Partners with the Sonder Project 2Health News:Southern Vacation Rentals Partners with the Sonder Project 3
... (May 12, 2008) The Virginia Commonwealth University School ... $6 million from the National Institutes of Healths National ... polycystic ovary syndrome, a disorder of the endocrine system ... Polycystic ovary syndrome, or PCOS, causes hormonal imbalances leading ...
... impact and other influences are limiting the growth ... of frequency and severity of ... AOC ),the leading provider of global risk management and consulting ... care industry,finding for the first time in nine years of ...
... ... oxide material., DENVER, May 12 C5 Medical Werks, ... has submitted a 510(k),pre-market notification to the U.S. Food and ... CAD/CAM Blocks.,ZirDent(TM) is a zirconium material ideally suited to meet ...
... proposals, to expand oral health care services; awards two significant oral ... ... 12 As part of the Illinois,Children,s Healthcare Foundation,s (ILCHF) $20 million, ... is pleased to announce a request for proposals in the oral,health care ...
... games throughout the ... region, PHILADELPHIA, May ... cosponsor the Senior Games, held at,dozens of locations throughout the five-county Philadelphia region. ... each,county, beginning Monday, May 12 and continuing through the month of June.,More than ...
... trial in bladder cancer exceeds 2/3rds enrolment level ... pre-clinical work in peritoneal cancers -, BELLEVILLE, ... (TSX: BNC), a research-based, technology-driven Canadian,biopharmaceutical company, is ... non-clinical development of its proprietary platform technology:,Mycobacterial Cell ...
Cached Medicine News:Health News:NIH grant to support Translational Research Center for PCOS 2Health News:Aon Study Finds Stability in Nationwide Liability Costs in the Long Term Health Care Sector 2Health News:Aon Study Finds Stability in Nationwide Liability Costs in the Long Term Health Care Sector 3Health News:C5 Medical Werks Applies for Clearance, Certification and Licensing for the Global Marketing of ZirDent(TM) Ceramic CAD/CAM Dental Blocks 2Health News:Children in Illinois to Have Healthier Smiles 2Health News:Independence Blue Cross Supports 2008 Senior Games 2Health News:Bioniche Updates re: Mycobacterial Cell Wall Technology Platform 2Health News:Bioniche Updates re: Mycobacterial Cell Wall Technology Platform 3Health News:Bioniche Updates re: Mycobacterial Cell Wall Technology Platform 4
(Date:8/31/2015)... Aug. 31, 2015  Asterias Biotherapeutics, Inc. (NYSE ... emerging field of regenerative medicine, today announced that ... Chicago -based Rush University Medical Center ... of escalating doses of AST-OPC1 (oligodendrocyte progenitor cells) ... complete cervical spinal cord injury (SCI). This represents ...
(Date:8/31/2015)... WOODCLIFF LAKE, N.J. and STAMFORD, ... the U.S. pharmaceutical subsidiary of Eisai Co., Ltd., and ... into a worldwide collaboration agreement for the development and ... a dual orexin receptor antagonist entering Phase III clinical ... Under the terms of the agreement, Eisai and Purdue ...
(Date:8/31/2015)... Australia , Aug. 31, 2015 Bionomics ... discovery and development of innovative therapeutics for the treatment ... cancer, today announced that its BNC101 IND submission has ... (FDA). Bionomics plans to initiate a Phase 1 clinical ... patients with metastatic pancreatic cancer prior to 31 December ...
Breaking Medicine Technology:Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 4Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 5Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 6Eisai and Purdue Pharma Enter Worldwide Collaboration to Develop and Commercialize Lemborexant 2Eisai and Purdue Pharma Enter Worldwide Collaboration to Develop and Commercialize Lemborexant 3Eisai and Purdue Pharma Enter Worldwide Collaboration to Develop and Commercialize Lemborexant 4Eisai and Purdue Pharma Enter Worldwide Collaboration to Develop and Commercialize Lemborexant 5Successful BNC101 IND Submission Paves Way for Development of Promising Cancer Stem Cell Drug Candidate 2Successful BNC101 IND Submission Paves Way for Development of Promising Cancer Stem Cell Drug Candidate 3Successful BNC101 IND Submission Paves Way for Development of Promising Cancer Stem Cell Drug Candidate 4
... KeraCel Ophthalmic Products are ... formulation of lint-free MEROCEL polyvinyl ... configured to be beneficial to ... being absorbent, and yet firm ...
... Products provide the surgeon ... products for unparalleled fluid ... of fine microsurgical instruments. ... is highly absorbent, fast ...
... Merocel Ophthalmic Products provide ... fiber free products for ... safe cleaning of fine ... Merocel material is highly ...
Hard protective shields for post-operative or post-injury use. Universal, or Left/Right specific. Packaged 12 per box....
Medicine Products: