Navigation Links
Tobacco constituent extraction from snus during consumer use
Date:4/1/2013

Scientists at British American Tobacco have used a multi-analyte approach to determine the level of exposure to tobacco constituents of snus users. The results show that, generally, less than a third of each constituent measured was extracted by consumers during use.

Snus is a moist snuff that is placed under the upper lip. Epidemiological evidence, particularly from Sweden, suggests that snus use is substantially less hazardous than cigarette smoking because it is not associated with increased risks of lung cancer, oral cancer and chronic obstructive pulmonary disease.

In this study, reported in Chemistry Central Journal (10.1186/1752-153X-7-55), the constituents tested included nicotine, four tobacco-specific nitrosamines (TSNAs), propylene glycol, water, ammonium, nitrate, sodium, chloride, linalool, citronellol, linalyl acetate and geraniol. The researchers found that, generally, less than a third of each constituent was extracted by consumers during use.

'As well as being the first detailed description of methodology for extracting and quantifying such a range of analytes, the findings from this study give us an idea of the real-life exposure of consumers to snus constituents,' says Nathan Gale, a researcher at British American Tobacco Group Research & Development.

A multi-analyte approach was used, which involves concurrently extracting various tobacco constituents from the same snus pouch using methanol, ethanol and water. The technique, which was validated by comparing the data obtained this way with data obtained from the corresponding established single-analyte methods, was applied to a pilot study of users of Swedish pouched snus. The levels of constituents in snus pouches were determined before and after one hour of use by participants previous research has shown that the median residence time in the mouth is one hour.

The UK Royal College of Physicians has concluded that different categories of smokeless tobacco products (STPs) pose varying levels of risk to their users in line with their toxicant content. However, the findings from this research show that the toxicant content of STPs may not reflect what is actually ingested by consumers.

The results provide reference data for the development of a laboratory system that mimics the real-life extraction of tobacco constituents from snus. Such a system would be a cheaper and more efficient alternative to human studies.

In addition, the results show that exposure to snus constituents by consumers is a variable process. The researchers suggest that uptake may be affected by composition and amount of saliva, pressure and movement applied to the pouch during use, and different physiological characteristics of participants.

The next step is to apply the multi-analyte approach to different types of snus, in order to understand the effects of, for example, pouch size and water content. Further work is also needed to understand the importance of usage time, solubility of constituents in saliva, and real-life factors like consuming beverages or food while using snus.


'/>"/>

Contact: Dr Marina Murphy
marina_murphy@bat.com
44-077-111-50135
R&D at British American Tobacco
Source:Eurekalert

Related medicine news :

1. Many doctors do not provide tobacco cessation assistance to lung cancer patients
2. A billion deaths from tobacco are a key obstacle to global development
3. International Conference on Governance of Tobacco in the 21st Century
4. Californias Tobacco Control Program generates huge health care savings, UCSF study shows
5. Genetically modified tobacco plants produce antibodies to treat rabies
6. Researchers Identify Involuntary Tobacco Smoke Exposure in Boston Public Housing Authority Residents with Salivary Cotinine Testing from Salimetrics.
7. Treating tobacco addiction a duty, argue text editors
8. Smoking parents often expose children to tobacco smoke in their cars
9. Strong tobacco control policies in Brazil credited for more than 400,000 lives saved
10. Smoking and natural disasters: Christchurch residents increase tobacco consumption post-earthquake
11. Scientists ID Cancer-Causing Agent in Smokeless Tobacco
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... February 10, 2016 , ... The 9th annual meeting ... Congress (WMIC), will be held in New York City, NY on September 7 ... The congress will highlight and emphasize how imaging reveals a greater understanding of ...
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... working together to expand dental health services to the developmentally disabled in the ... Care Dental’s operations to a new facility at 71-949 Highway 111, Suite 100-B, ...
(Date:2/10/2016)... ... 10, 2016 , ... Compliancy Group LLC is pleased to ... throughout the country. The Guard was specifically designed to handle each element required ... regulatory updates, and compliance coaching. , In addition to meeting the compliance needs ...
(Date:2/10/2016)... ... ... Dr. Jessica Barron, of Barron Family Dental in Thornton, Colorado , ... in the North Metro Denver area. The new dental practice focuses on comfort where ... in the most relaxing environment. , While some dental visits can create anxiety for ...
(Date:2/10/2016)... ... February 10, 2016 , ... AxoGen, Inc. (NASDAQ: AXGN), a leading medical technology ... quarter and full year ended December 31, 2015 on Monday, February 29, 2016 after ... the investment community following the release at 4:30 PM ET. Investors interested in participating ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... England och PITTSBURGH ... Erbjudandet lämnas inte, och detta pressmeddelande ... indirekt, i eller till, och inga anmälningssedlar ... av aktieägare i, något land där Erbjudandet, ... accept av Erbjudandet skulle strida mot tillämpliga ...
(Date:2/10/2016)... February 10, 2016 A new report from business intelligence ... states that the Alzheimer,s disease market will more than double from just under ... Compound Annual Growth Rate (CAGR) of 11%. Canada , ... , Spain , the UK, and Japan ... forecast period. --> Canada , France ...
(Date:2/10/2016)... , Feb. 10, 2016 Urologix, the ... the treatment of Benign Prostatic Hyperplasia (BPH), announces new ... Ash Keswani , a medical device industry veteran of ... the Limited Liability Company.  Plymouth, ... service lines, Cooled ThermoTherapy™ and Prostiva® RF Therapy, will ...
Breaking Medicine Technology: