Navigation Links
Tobacco company misrepresented danger from cigarettes
Date:1/6/2012

A new UCSF analysis of tobacco industry documents shows that Philip Morris USA manipulated data on the effects of additives in cigarettes, including menthol, obscuring actual toxicity levels and increasing the risk of heart, cancer and other diseases for smokers.

Tobacco industry information can't be taken at face value, the researchers conclude. They say their work provides evidence that hundreds of additives, including menthol, should be eliminated from cigarettes on public health grounds.

The article is published in PLoS Medicine http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1001145

In the new, independent study, the scientists reassessed data from Philip Morris' "Project MIX," which detailed chemical analyses of smoke and animal toxicology studies of 333 cigarette additives. Philip Morris, the nation's largest tobacco company, published its findings in 2002.

By investigating the origins and design of Project MIX, the UCSF researchers conducted their own inquiry into the Philip Morris results. They stressed that many of the toxins in cigarette smoke substantially increased after additives were added to cigarettes.

They also found, after obtaining evidence that additives increased toxicity, that tobacco scientists adjusted the protocol for presenting their results in a way that obscured these increases.

"We discovered these post-hoc changes in analytical protocols after the industry scientists found that the additives increased cigarette toxicity by increasing the number of fine particles in the cigarette smoke that cause heart and other diseases," said senior author Stanton A. Glantz, PhD, UCSF professor of medicine and director of the Center for Tobacco Control Research and Education at UCSF.

"When we conducted our own analysis by studying additives per cigarette following Philip Morris' original protocol -- we found that 15 carcinogenic chemicals increased by 20 percent or more," he said.

Additionally, in the independent study, the researchers discovered the reason behind Philip Morris' failure to identify many toxic effects in animal studies: its studies were too small.

"The experiment was too small in terms of the number of rats analyzed to statistically detect important changes in biological effects," Glantz said. "Philip Morris underpowered its own studies."

The results of "Project MIX" were first published as four papers in a 2002 edition of Food and Chemical Toxicology, a journal whose editor and many members of its editorial board had financial ties to the tobacco industry. While Philip Morris was trying to get the papers published, the company scientist who led Project Mix sent an email to a colleague describing the peer review process as "an inside job." http://legacy.library.ucsf.edu/tid/ekw86a00/pdf?search=%22inside%20job%20philip%20morris%20project%20mix%20email%22

In the new study, the researchers used documents made public as a result of litigation against the tobacco industry. The documents are available to the public through UCSF's Legacy Tobacco Documents Library.


'/>"/>
Contact: Elizabeth Fernandez
elizabeth.fernandez@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

Related medicine news :

1. New report identifies research needed on modified risk tobacco products
2. UCSF to receive tobacco papers, funding to improve public access to the documents
3. States could see substantial savings with tobacco control programs
4. UIC awarded $14 million to study tobacco pricing and media
5. National Study Will Track Tobacco Use in U.S.
6. FDA and NIH announce joint study on tobacco use and risk perceptions
7. Big Tobacco knew radioactive particles in cigarettes posed cancer risk but kept quiet
8. Stronger tobacco control policy in the Netherlands would save thousands of lives
9. UCSF, UC Merced to study effectiveness of anti-tobacco programs
10. Effects of tobacco use among rural African American young adult males
11. Illegal Tobacco Sales to U.S. Minors Reach All-Time Low
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tobacco company misrepresented danger from cigarettes
(Date:12/4/2016)... , ... December 03, 2016 , ... While James Earl ... serving as host for in a show called "Front Page". One of the forthcoming ... years, breast cancer rates have plummeted in large part due to early detection. Like ...
(Date:12/4/2016)... Washington DC (PRWEB) , ... December 04, 2016 , ... ... Environmental, one of the most certified and experienced Indoor Air Quality Companies in VA, ... Assessment and Remediation Regulations. , The new mold law in the district ...
(Date:12/2/2016)... ... December 02, 2016 , ... On Dec. 2, 2016, CURE® magazine ... San Diego honoring the 2016 MPN Heroes—eight individuals who have made a difference in ... and beyond the standard of care, demonstrating leadership within the MPN community and/or a ...
(Date:12/2/2016)... ... 2016 , ... Center for Autism and Related Disorders (CARD) Portland today announced ... disorder (ASD) and other developmental disabilities. The group, which is being launched with the ... the opportunity to share stories and advice, seek help, and continue their education on ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... California, will be included in the 2016 “Guide to America’s Top Plastic Surgeons” ... on the amalgamation of their education, experience, and professional associations. , One ...
Breaking Medicine News(10 mins):
(Date:12/4/2016)... 3, 2016 Johnson & Weaver, LLP announces that ... of Zimmer Biomet Holdings, Inc. (NYSE: ZBH ) ... 31, 2016 (the "Class Period"). Zimmer Biomet provides ... orthopaedic reconstructive products, such as knee and hip reconstructive products. ... , , ...
(Date:12/4/2016)...   Pairnomix, LLC, a genetic research company and ... the White House, today announced that findings from its first ... candidate therapies for a patient with epileptic encephalopathy caused by ... at the 70 th Annual Meeting of the ... , December 2-6, 2016.  Pairnomix, unique process involves ...
(Date:12/4/2016)...  Results from the Phase II SUSTAIN study show ... the median annual rate of sickle cell-related pain crises ... p=0.010) in patients with or without hydroxyurea therapy 1 ... featured in the official press briefing at the 58 ... and presented during the Plenary Scientific Session tomorrow (Abstract ...
Breaking Medicine Technology: