Navigation Links
Tobacco company misrepresented danger from cigarettes
Date:1/6/2012

A new UCSF analysis of tobacco industry documents shows that Philip Morris USA manipulated data on the effects of additives in cigarettes, including menthol, obscuring actual toxicity levels and increasing the risk of heart, cancer and other diseases for smokers.

Tobacco industry information can't be taken at face value, the researchers conclude. They say their work provides evidence that hundreds of additives, including menthol, should be eliminated from cigarettes on public health grounds.

The article is published in PLoS Medicine http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1001145

In the new, independent study, the scientists reassessed data from Philip Morris' "Project MIX," which detailed chemical analyses of smoke and animal toxicology studies of 333 cigarette additives. Philip Morris, the nation's largest tobacco company, published its findings in 2002.

By investigating the origins and design of Project MIX, the UCSF researchers conducted their own inquiry into the Philip Morris results. They stressed that many of the toxins in cigarette smoke substantially increased after additives were added to cigarettes.

They also found, after obtaining evidence that additives increased toxicity, that tobacco scientists adjusted the protocol for presenting their results in a way that obscured these increases.

"We discovered these post-hoc changes in analytical protocols after the industry scientists found that the additives increased cigarette toxicity by increasing the number of fine particles in the cigarette smoke that cause heart and other diseases," said senior author Stanton A. Glantz, PhD, UCSF professor of medicine and director of the Center for Tobacco Control Research and Education at UCSF.

"When we conducted our own analysis by studying additives per cigarette following Philip Morris' original protocol -- we found that 15 carcinogenic chemicals increased by 20 percent or more," he said.

Additionally, in the independent study, the researchers discovered the reason behind Philip Morris' failure to identify many toxic effects in animal studies: its studies were too small.

"The experiment was too small in terms of the number of rats analyzed to statistically detect important changes in biological effects," Glantz said. "Philip Morris underpowered its own studies."

The results of "Project MIX" were first published as four papers in a 2002 edition of Food and Chemical Toxicology, a journal whose editor and many members of its editorial board had financial ties to the tobacco industry. While Philip Morris was trying to get the papers published, the company scientist who led Project Mix sent an email to a colleague describing the peer review process as "an inside job." http://legacy.library.ucsf.edu/tid/ekw86a00/pdf?search=%22inside%20job%20philip%20morris%20project%20mix%20email%22

In the new study, the researchers used documents made public as a result of litigation against the tobacco industry. The documents are available to the public through UCSF's Legacy Tobacco Documents Library.


'/>"/>
Contact: Elizabeth Fernandez
elizabeth.fernandez@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

Related medicine news :

1. New report identifies research needed on modified risk tobacco products
2. UCSF to receive tobacco papers, funding to improve public access to the documents
3. States could see substantial savings with tobacco control programs
4. UIC awarded $14 million to study tobacco pricing and media
5. National Study Will Track Tobacco Use in U.S.
6. FDA and NIH announce joint study on tobacco use and risk perceptions
7. Big Tobacco knew radioactive particles in cigarettes posed cancer risk but kept quiet
8. Stronger tobacco control policy in the Netherlands would save thousands of lives
9. UCSF, UC Merced to study effectiveness of anti-tobacco programs
10. Effects of tobacco use among rural African American young adult males
11. Illegal Tobacco Sales to U.S. Minors Reach All-Time Low
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tobacco company misrepresented danger from cigarettes
(Date:5/2/2016)... Texas (PRWEB) , ... May 02, 2016 , ... The ... a time to honor the civilian nurses that care for its uniformed service members, ... signed a proclamation in 1974 designating May 6th through May 12th National Nurses Week. ...
(Date:5/2/2016)... ... May 02, 2016 , ... In honor of National Physical Fitness and Sports ... who share their fitness journey on social media. , The foot care company, ... a $100 product voucher each week during May to one winner. , “Whether the ...
(Date:5/2/2016)... ... 2016 , ... Over $60 Billion is spent annually on products for our ... product review site for Toys, Tots, Pets & More (TTPM) announced the 15 winners ... at the Metropolitan Pavilion in New York City. , Chosen from a field of ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... Further establishing ... to announce that the new WHIMZEES Variety Value Boxes were selected from over 1,000 ... Product Showcase Award. , WHIMZEES natural dental chews for dogs are a favorite ...
(Date:5/2/2016)... ... ... World Ultimate & Guts Championship (WUGC) Mixed roster was announced in February and Chris Mazur, ... being held in London, England this year from June 18-25. At the last WUGC in ... the women’s masters division, and a silver in the women’s division, so Mazur hopes to ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... , May 2, 2016  Deerfield announced today ... of Graybug Vision, Inc. Graybug Vision is an ... that may transform care for ocular diseases including ... Vision,s technology was first developed at Johns Hopkins ... startup venture. Graybug Vision is ...
(Date:5/2/2016)... 2016 The global  ultrasound ... billion by 2024, according to a new report ... of the sonography market include expanding applications of ... for periodic ultrasound screenings of the breast for ... ) High Intensity Focused Ultrasound ...
(Date:4/29/2016)... New Jersey , April 29, 2016 /PRNewswire/ ... Software Suite for Life Sciences, Product Development Capabilities ... Global Life Science Customer Base . ... solutions provider, today announced the acquisition of Skura ... a global leader in adaptive sales enablement technology ...
Breaking Medicine Technology: