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To make old skin cells act young again, boost their surroundings, U-M scientists show
Date:12/10/2012

he fibroblasts began expressing collagen-related genes, producing more collagen, and connecting better to the ECM. The entire layer of skin grew thicker, and more blood vessels, which nourished the cells were seen.

"Fragmentation of the extracellular matrix plays an important role in skin aging, but by altering the matrix using an external filler and increasing the internal pressure, we've shown that we can essentially trigger a signal for cells to wake up," says Gary Fisher, Ph.D., the Harry Helfman Professor of Molecular Dermatology and senior author of the new study, published in the Journal of Investigative Dermatology.

He cautions that the new work, done together with U-M associate research professor Taihao Quan, Ph.D., and assistant professor Frank Wang, M.D., and colleagues, does not mean that cosmetic filler should be used throughout the body.

Rather, the importance of the discovery lies in the potential to harness the broader understanding of the ECM for prevention and treatment.

For instance, skin thinning as we age leaves us more prone to skin tearing and interferes with healing after incisions or injury. Better understanding of how the ECM helps support healing could lead to better strategies for helping patients.

"This shows that skin cells in elderly people have the capacity to respond robustly in a very positive way to alterations in the mechanical property of their environment," says Fisher. "We still need to know more about how cells sense their environment, but in general it appears we have made a real difference in the structural integrity of skin."


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Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

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