Navigation Links
To make old skin cells act young again, boost their surroundings, U-M scientists show
Date:12/10/2012

he fibroblasts began expressing collagen-related genes, producing more collagen, and connecting better to the ECM. The entire layer of skin grew thicker, and more blood vessels, which nourished the cells were seen.

"Fragmentation of the extracellular matrix plays an important role in skin aging, but by altering the matrix using an external filler and increasing the internal pressure, we've shown that we can essentially trigger a signal for cells to wake up," says Gary Fisher, Ph.D., the Harry Helfman Professor of Molecular Dermatology and senior author of the new study, published in the Journal of Investigative Dermatology.

He cautions that the new work, done together with U-M associate research professor Taihao Quan, Ph.D., and assistant professor Frank Wang, M.D., and colleagues, does not mean that cosmetic filler should be used throughout the body.

Rather, the importance of the discovery lies in the potential to harness the broader understanding of the ECM for prevention and treatment.

For instance, skin thinning as we age leaves us more prone to skin tearing and interferes with healing after incisions or injury. Better understanding of how the ECM helps support healing could lead to better strategies for helping patients.

"This shows that skin cells in elderly people have the capacity to respond robustly in a very positive way to alterations in the mechanical property of their environment," says Fisher. "We still need to know more about how cells sense their environment, but in general it appears we have made a real difference in the structural integrity of skin."


'/>"/>

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New drug prevents spread of human prostate cancer cells
2. Tiny hitchhikers attack cancer cells
3. To prevent leukemias dreaded return, go for the stem cells
4. Scientists identify major source of cells defense against oxidative stress
5. Therapy exploits addiction of leukemia cells
6. IBN discovers human neural stem cells with tumor targeting ability
7. Leukaemia cells have a remembrance of things past
8. Small molecular bodyguards kill HPV-infected cancer cells by protecting tumor-suppressor
9. Research yields new clues to how brain cancer cells migrate and invade
10. Presence of fetal cells in women lowers risk of breast cancer but raises risk of colon cancer
11. Researchers Rejuvenate Blood-Forming Stem Cells in Mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... Ticket Down is a reputable source for ... MI on Saturday, August 2nd. Two of the most ... competing on American soil on Aug. 2 when Manchester United and ... The home of the University of Michigan is also known as ... all of American sports and has also hosted numerous other monumental ...
(Date:7/30/2014)... Good Neighbor Community Services announced that ... of Innovations with Ed Begley Jr, airing later ... times TBA. , In this segment, viewers will ... to redefine the traditional approach to serving the ... passion, innovation, determination, excellence, and collaboration, Good Community ...
(Date:7/30/2014)... HealthDay Reporter WEDNESDAY, July 30, 2014 ... shed excess pounds may want to team up with their ... in a supervised behavioral modification program gained less weight than ... (an average difference of about four pounds over two years). ... two years, according to the study. "In a nutshell, ...
(Date:7/30/2014)... Volunteers from the Church of Scientology of ... summer with massive distribution of Truth About Drugs ... volunteers on Strøget, the famous Copenhagen walking street. ... and its ambiance, some quarter of a million people ... , These activities are part of a coordinating ...
(Date:7/30/2014)... fuel cancer as well as evolutionary changes in a ... occur randomly throughout the genome. , However, recent studies ... of multiple mutations that arise simultaneously and in close ... are frequently found in regions where chromosomal rearrangements take ... Cell Reports , may one day lead to new ...
Breaking Medicine News(10 mins):Health News:Manchester United vs. Real Madrid Tickets Ann Arbor: Ticket Down Slashes Ticket Prices for Real Madrid vs. ManU Guinness International Champions Cup Match 2Health News:Manchester United vs. Real Madrid Tickets Ann Arbor: Ticket Down Slashes Ticket Prices for Real Madrid vs. ManU Guinness International Champions Cup Match 3Health News:Manchester United vs. Real Madrid Tickets Ann Arbor: Ticket Down Slashes Ticket Prices for Real Madrid vs. ManU Guinness International Champions Cup Match 4Health News:Good Neighbor Community Services to be Featured in an Upcoming Episode of Innovations With Ed Begley, Jr. 2Health News:Make Kids' Weight Loss a Family Affair, Study Suggests 2Health News:Make Kids' Weight Loss a Family Affair, Study Suggests 3Health News:Make Kids' Weight Loss a Family Affair, Study Suggests 4Health News:Biologists describe mechanism promoting multiple DNA mutations 2
... Sources Preferred Over Imports), FRESNO, Calif., Oct. 16 ... their confidence in the food supply has,decreased over the ... California Olive Industry. The registered dieticians and nutritionists ... saying that when presented with a,choice, they prefer food ...
... NASHVILLE, Tenn., Oct. 16 HCA today announced the,appointment ... West Division,which is based in Las Vegas, effective Jan. ... retirement. As Far West Division President, Rogers will ... currently include nine,hospitals and seven ambulatory surgery centers with ...
... Feature Special Performances by John Legend, Joss Stone, ... Patti Labelle & ... for Cancer,Research will honor four outstanding individuals at the 2007 Angel ... BET Networks Debra L. Lee, Chief Hematologic Oncology,Memorial Sloan-Kettering Cancer Center ...
... but some people may prefer one option over the ... with "mid-range" -- or intermediate -- coronary artery disease ... help decide between angioplasty to open blocked arteries or ... say. , The long-term safety of the two procedures ...
... be the main cause of chronic gastritis and peptic ulcer ... evidence of H pylori infection in over 90% of cases ... the reason for low incidence of H pylori infection in ... this issue was recently reported in the November 7 issue ...
... with behind-the-wheel training can significantly improve their driving performance, ... of The Journal of Gerontology: Medical Sciences ... by Yale University,s Richard Marottoli examined 126 drivers aged ... classroom instruction and two hours of behind-the-wheel training (based ...
Cached Medicine News:Health News:Dieticians & Nutritionists Report Decreased Confidence in Food Supply 2Health News:Bryan R. Rogers Appointed President of Far West Division 2Health News:The G&P Foundation Celebrates 10 Years of Funding Life Saving Research at The 2007 Angel Ball Honoring Glenda Bailey, Debra L. Lee, Dr. Stephen D. Nimer and the Late H.H. Sheik Zayed Bin Sultan Al Nahyan 2Health News:The G&P Foundation Celebrates 10 Years of Funding Life Saving Research at The 2007 Angel Ball Honoring Glenda Bailey, Debra L. Lee, Dr. Stephen D. Nimer and the Late H.H. Sheik Zayed Bin Sultan Al Nahyan 3Health News:The G&P Foundation Celebrates 10 Years of Funding Life Saving Research at The 2007 Angel Ball Honoring Glenda Bailey, Debra L. Lee, Dr. Stephen D. Nimer and the Late H.H. Sheik Zayed Bin Sultan Al Nahyan 4Health News:The G&P Foundation Celebrates 10 Years of Funding Life Saving Research at The 2007 Angel Ball Honoring Glenda Bailey, Debra L. Lee, Dr. Stephen D. Nimer and the Late H.H. Sheik Zayed Bin Sultan Al Nahyan 5Health News:Angioplasty Equals Bypass Surgery for Heart Patients: Study 2Health News:Angioplasty Equals Bypass Surgery for Heart Patients: Study 3Health News:A low prevalence of H pylori in HIV-positive patients 2
(Date:7/30/2014)... , July 30, 2014  There is still ... organization,s success. The 10th Annual Institute for Supply ... for Excellence in Supply Management is open for ... the understanding and importance of supply management by ... and best supply management practices.  Entries are due ...
(Date:7/30/2014)... 30, 2014 Advanced Photonix ® (NYSE MKT: ... 2014) financial results on Monday, August 11, 2014. A press ... close of the market and the Company will host a ... p.m. EDT on the same day. Participating in ... Director), Rob Risser (COO and Director), and ...
(Date:7/30/2014)... Mass., July 30, 2014  Hologic, Inc. (NASDAQ: ... third fiscal quarter ended June 28, 2014. ... Revenues increased 1.0% to $632.6 million, reflecting operational growth ... compared to the same period in the prior year. ... business segments. , Breast Health revenues grew 3.5%. ...
Breaking Medicine Technology:Institute for Supply Management, Michigan State University to recognize companies with excellent supply management practices 2Advanced Photonix to Webcast Fiscal 2015 First Quarter Earnings 2Hologic Announces Third Quarter Fiscal 2014 Operating Results 2Hologic Announces Third Quarter Fiscal 2014 Operating Results 3Hologic Announces Third Quarter Fiscal 2014 Operating Results 4Hologic Announces Third Quarter Fiscal 2014 Operating Results 5Hologic Announces Third Quarter Fiscal 2014 Operating Results 6Hologic Announces Third Quarter Fiscal 2014 Operating Results 7Hologic Announces Third Quarter Fiscal 2014 Operating Results 8Hologic Announces Third Quarter Fiscal 2014 Operating Results 9Hologic Announces Third Quarter Fiscal 2014 Operating Results 10Hologic Announces Third Quarter Fiscal 2014 Operating Results 11Hologic Announces Third Quarter Fiscal 2014 Operating Results 12Hologic Announces Third Quarter Fiscal 2014 Operating Results 13Hologic Announces Third Quarter Fiscal 2014 Operating Results 14Hologic Announces Third Quarter Fiscal 2014 Operating Results 15Hologic Announces Third Quarter Fiscal 2014 Operating Results 16Hologic Announces Third Quarter Fiscal 2014 Operating Results 17
... Reportlinker.com announces that a new market research ... Pharmaceuticals: Global Industry Guide ... Pharmaceuticals: Global Industry Guide is ... analysis covering the Pharmaceuticals industry. It includes ...
... 2012 Ampio Pharmaceuticals, Inc. (Nasdaq: AMPE ... three lead drugs (Zertane™ completed two phase ... licensing distribution of these drugs and engaged in further ... interim review of the first 50% of patients enrolled ...
Cached Medicine Technology:Pharmaceuticals: Global Industry Guide 2Pharmaceuticals: Global Industry Guide 3Pharmaceuticals: Global Industry Guide 4Pharmaceuticals: Global Industry Guide 5Pharmaceuticals: Global Industry Guide 6Pharmaceuticals: Global Industry Guide 7Pharmaceuticals: Global Industry Guide 8Pharmaceuticals: Global Industry Guide 9Pharmaceuticals: Global Industry Guide 10Pharmaceuticals: Global Industry Guide 11Pharmaceuticals: Global Industry Guide 12Pharmaceuticals: Global Industry Guide 13Pharmaceuticals: Global Industry Guide 14Pharmaceuticals: Global Industry Guide 15Ampio Announces Positive Preliminary Update on the Optina™ Clinical Trial to Treat Diabetic Macular Edema and Decision to Conclude the Study Ahead of Schedule 2Ampio Announces Positive Preliminary Update on the Optina™ Clinical Trial to Treat Diabetic Macular Edema and Decision to Conclude the Study Ahead of Schedule 3Ampio Announces Positive Preliminary Update on the Optina™ Clinical Trial to Treat Diabetic Macular Edema and Decision to Conclude the Study Ahead of Schedule 4
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: