Navigation Links
To fight incurable metastatic breast cancer, resistance must be broken
Date:12/10/2012

One of the most frustrating truths about cancer is that even when a treatment works, it often doesnt work for long because cancer cells find ways to resist. However, researchers reporting studies done in mice in the December 11, 2012, issue of Cancer Cell, a Cell Press publication, may have a way to stay one step ahead in the case of aggressive metastatic breast cancer.

The findings emphasize the importance of basic cancer biology for advancing treatments that are more effective and less toxic, the researchers say.

"We need to gain a better understanding of the wiring diagram of cancer cells in order to anticipate resistance mechanisms and plan the right combination therapies," says Mohamed Bentires-Alj of the Friedrich Miescher Institute for Biomedical Research in Switzerland. "Moreover, we need to better understand how cancer progresses to metastases."

After all, the spreading of cancer through metastasis is responsible for most cancer-related deaths.

In the new study, Bentires-Alj and his colleagues examined cancer cell lines and primary breast tumors to see what happens when those cancers are treated with a new type of therapy that targets the so-called PI3K pathway.

"The PI3K pathway is frequently mutated and activated in several human cancers where it plays a key role in tumor development and maintenance as well as in resistance to therapy," Bentires-Alj says, which explains why clinical trials evaluating some 26 PI3K inhibitors are now underway.

While those inhibitors are promising, there is some bad news, as the new work shows. When triple-negative breast tumors are hit with PI3K inhibitors, cancer cells begin to produce a chemical that ramps up a second cancer pathway (JAK2/STAT5)one that encourages the cancer to spread.

Now for the good news: when the researchers treated mice with an aggressive form of breast cancer with drugs to block both PI3K and JAK2/STAT5 pathways, their tumors grew more slowly, spread less readily, and, ultimately, the animals lived longer.

If Bentires-Alj has his way, the findings in mice will lead to clinical trials in the patients who are most likely to benefit: those with particularly aggressive, triple-negative breast cancers.

"We are in the era of personalized medicine," he says. "We hope that this combination therapy will be tested in clinical trials and that the right patients will be selected for these studies."


'/>"/>

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Related medicine news :

1. DXE Medical, Inc. Donates to Franklin Firefighters Annual Christmas Toy and Clothing Drive
2. Teen Fighting Declines in U.S., Europe
3. Cocktail boosts immune cells in fighting cancer
4. Use Social Media to Fight Childhood Obesity, Heart Experts Say
5. St. Louis Rams Seek Flawless Execution® Training from Fighter Pilots to Take Back Season
6. 5 big strides to fight lung disease in our tiniest patients
7. Colorful Fruits, Vegetables May Be Key to Cancer-Fighting Diet
8. University of Tennessee study: Unexpected microbes fighting harmful greenhouse gas
9. Virtual reality could help people lose weight, fight prejudice
10. New bacteria to fight against intestinal inflammation
11. Could Cholesterol Treatment Fight Repeat Heart Attack?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... ... July 24, 2017 , ... On July 19th, ... set up, and the awarding ceremony was held successfully in Beijing. The State ... the army's health system, and national Chinese medicine experts also attended the event, ...
(Date:7/24/2017)... ... July 24, 2017 , ... “The Perfect Gift”: a customizable and interactive Bible study guide ... Huckett is a born-again Christian. She has always accepted Christ as her Savior, yet ... She was in the Spirit when she wrote this book to her children, so they ...
(Date:7/24/2017)... ... July 24, 2017 , ... “A Short Walk to the ... Mailbox” is the creation of published author, Ed Clark. Ed Clark is a ... Christian Reformed churches as a minister of music and worship leader for over fifty ...
(Date:7/24/2017)... ... 2017 , ... The Center for Addiction Recovery Training (CART), ... a second Multiple Pathways of Recovery Conference on October 23-26, 2017. This year, ... CCAR’s foundational principle – a belief in multiple pathways of recovery, aims to ...
(Date:7/23/2017)... IL (PRWEB) , ... July ... ... of Eating Disorders Professionals ™(iaedp), the leading provider of education and training ... training in preparation for competency for Traditional Certification: the iaedp™ Core Curriculum. ...
Breaking Medicine News(10 mins):
(Date:7/14/2017)... , July 14, 2017 Endo International plc (NASDAQ: ... Tuesday, August 8, 2017.  Members of its senior management team will ... open at 8:30 a.m. ET. The dial-in number ... 497-0462, International (678) 509-7598, and the passcode is 45397076. Please dial ... A replay of the call will ...
(Date:7/13/2017)... July 13, 2017 RK Logistics Group, Inc. was ... certification for its Fremont, CA headquarters ... the Tri-Valley and San Jose for ... of Fremont , with its Fremont Innovation District, is ... such a powerful resource to the hundreds of biotech, pharma ...
(Date:7/12/2017)...  Eli Lilly and Company (NYSE: LLY ) ... resolve pending patent litigation in the U.S. District Court for ... the Cialis ® (tadalafil) unit dose patent. This patent ... part of the agreement, Cialis exclusivity is now expected to ... "The unit dose patent for Cialis is valid and infringed ...
Breaking Medicine Technology: