Navigation Links
To combat deadly brain cancer, target the stem cells
Date:7/7/2011

Researchers have uncovered a new target that could stop the growth of glioblastoma, a deadly form of brain cancer. In the July 8th issue of the journal Cell, a Cell Press publication, a new study identifies an enzyme found in glioma stem cells that allows them to grow and seed tumors. Importantly, normal stem cells, including those in the brain, don't appear to share that same dependency.

"When thinking about therapeutics [targeting cancer stem cells], you have to be careful that you aren't interfering with normal stem cells," said Christine Eyler of the Cleveland Clinic. "Glioma stem cells are not derived from normal stem cells but they do share many features with them. The trick to therapy is to find pathways exhibited only by cancer stem cells."

The goal of Eyler's team, led by Cleveland Clinic scientist Jeremy Rich, was to identify just such a pathway in glioma stem cells, a particularly devastating form of brain cancer. Despite modern surgical and medical therapies, those diagnosed with a glioblastoma have a median survival of just over a year.

Previous work identifying glioma cells with stem-cell like behavior and demonstrating the propagation of gliomas in animals offered hope for the development of anti-glioma therapeutics. The challenge, however, has been finding pathways that differ between glioma and normal stem cells in spite of evidence that the glioma stem cells closely resemble embryonic and neural stem cells.

Earlier studies led the researchers to investigate the pathway that produces nitric oxide (NO), a molecule thought to support tumors' growth and resistance to treatment. Those experiments showed that glioma cells express varying levels of nitric oxide synthases, critical enzymes in that pathway.

"It's important to note that there are different forms of nitric oxide synthases," said Anita Hjelmeland, also at the Cleveland Clinic. "We focused on one that is well restricted to glioma stem ce
'/>"/>

Contact: Elisabeth Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Video games may help combat depression in older adults
2. National Hispanic Council on Aging Joins the Administration in Mission to Combat Medicare Fraud By Empowering Hispanics
3. SC Johnson and Bill & Melinda Gates Foundation Unite to Combat Malaria
4. Combat E-Cigarette in Demand by Civilians
5. The Net Impact Creates Website for St. Louis Event to Combat the Stigma of Mental Illness
6. HIV Drugs Might Combat Two Other Diseases
7. Children of combat-deployed parents show increased worries, even after parent returns
8. HealthMETRICS Partners, Inc. Article in AJMC Outlines Innovative Approach to Combat Rising Healthcare Costs
9. Holistic Management and Allan Savory Win the 2010 Buckminster Fuller Award for Turning Deserts into Thriving Grasslands and Combating Climate Change.
10. Novel Drug Combats Advanced Melanoma
11. US Army 2010 Combat Casualty Care Conference, Aug. 16-19, St. Pete Beach, Fla.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... May 22, 2015 Mountain Point Medical Center, ... ribbon cutting ceremony on Friday, May 29, 2015 at 11 ... 6 p.m. The new medical center, set to officially open ... Boulevard, Lehi, UT 84043. , “The opening of Mountain ... and the Utah County community,” said Kent Loosle, CEO of ...
(Date:5/22/2015)... May 22, 2015 Omar Ahmad Barrada, ... to participate in the 2015 Congress of Future Medical ... as a gathering of “America’s highest achieving high school ... of healthcare, set new goals and learn better study ... live surgery, during which we can ask the surgeons ...
(Date:5/22/2015)... 22, 2015 Family, friends, students, colleagues, ... surgical oncologist, Dr. LaSalle D. Leffall, on Monday, May ... began after Grand Rounds in the hospital’s Tower Auditorium. ... outside the auditorium, trying to keep the secret. “I’d ... he sees me, he’ll know something is up,” she ...
(Date:5/22/2015)... 22, 2015 According to a new Aegis ... are equally as likely to worry about what will happen ... X, 77% Boomers, 69% Silent Generation), which may help explain ... scared of aging, particularly Millennials (47%), Gen X’ers (51%), and ... in April, 2015 among more than 2,000 U.S. adults ages ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 According to ... hub for drug related death, totaling almost 2,500 confirmed drug ... reported by state officials, totals 2,489 deaths stemming from legal ... out, Pennsylvania loses seven people every day to fatal overdoses ... been singled out as one of the most rife with ...
Breaking Medicine News(10 mins):Health News:Mountain Point Medical Center, a Campus of Jordan Valley Medical Center, Hosts Ribbon Cutting Ceremony and Community Celebration on Friday, May 29, 2015 2Health News:Milton Hershey School Student Chosen for Congress of Future Medical Leaders 2Health News:Colleagues Surprise Dr. LaSalle Leffall with 85th Birthday Celebration 2Health News:New Study Reveals America’s Fear of Aging 2Health News:New Study Reveals America’s Fear of Aging 3Health News:Philadelphia Ranks Among the Tops Cities in Penn. for Drug Deaths 2
... at the Salk Institute for Biological Studies, fisetin, a ... fruits and vegetables, invigorates signaling pathways that boost long-term ... week’s Online Early Edition of the Proceedings of the ... in over 30% of the people aged 60 and ...
... in US have come up with a heady option that ... in brain cells often after an episode of stroke or ... John Hopkins University ,who conducted a study on mice, ... the skin of red grapes, administered in moderate doses, showed ...
... three sisters Julie Owen, Pam Dugmore and Rosemary Moss at ... which determined// whether they were carriers of a mutated gene ... of developing breast cancer. ,The results revealed that ... gene. Only Rosemary, 64, did not. The sisters were advised ...
... who are gluten intolerant run four times the risk of ... print in Thorax. // ,Gluten intolerance, or ... bowel, caused by an exaggerated immune response to the gluten ... up to 1% of the population, and has been linked ...
... supplements for good health despite the fact that few actually ... the best way to stay healthy is a balanced diet. ... worried that food has fewer nutrients than it used to, ... is freshly picked produce, reported the online edition of Daily ...
... the fatal lung disease; Chronic Obstructive Pulmonary Disease (COPD) ... smokers//. ,Chronic bronchitis and emphysema constitute COPD, ... globe. Cough, fatigue, shortness of breath and subsequent difficulty ... ,The scientists at the Hvidovre Hospital in Denmark conducted ...
Cached Medicine News:Health News:Eating Strawberries may boost memory 2Health News:Eating Strawberries may boost memory 3Health News:A Family's Fight against Breast cancer 2Health News:A Family's Fight against Breast cancer 3Health News:Madhya Pradesh Tops in Implementing Child Health Scheme 2
(Date:5/22/2015)... KING OF PRUSSIA, Pa. , May 22, 2015 ... CSL Behring its 2015 Corporate Leadership Award as ... science and improving the care of the bleeding disorders community.  ... and Managing Director, CSL Limited, during the NHF Annual Spring ... May 21. "The National Hemophilia Foundation is dedicated ...
(Date:5/22/2015)... InspireMD, Inc. (NYSE MKT: NSPR) ("InspireMD" or the "Company"), ... that its CGuard TM Embolic Prevention System reported positive ... Musialek , at the EuroPCR conference on May ... PARADIGM, an investigator-initiated P rospective evaluation of ... revascularization I n symptomatic and increased-risk asymptomatic carotid artery ...
(Date:5/22/2015)... 2015 AcelRx Pharmaceuticals, Inc. (Nasdaq: ACRX ... and commercialization of innovative therapies for the treatment of ... executive officer Howie Rosen will be presenting ... Tim Morris will be presenting at JMP ... are as follows: Jefferies 2015 Healthcare Conference ...
Breaking Medicine Technology:National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 2National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 3National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 4InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 2InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 3InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 4AcelRx Pharmaceuticals to Present at Two Upcoming Investor Conferences In June 2
... Medical Affiliates, Inc. (Pink Sheets: UCIA ) today announced ... the quarter ended June 30, 2010. Revenues for the ... or 9.23% over revenues of $19,264,467 for the quarter ended June ... the quarter ended June 30, 2010 compared to net income of ...
... is pleased to announce that Robert R. Bulger, M.D. ... of minimally invasive back pain treatment techniques.  The ... a variety of conditions responsible for back pain on ... American Spine,s trained physicians are the only doctors performing ...
Cached Medicine Technology:UCI Medical Affiliates, Inc. Reports Third Quarter Results for Fiscal Year 2010 2UCI Medical Affiliates, Inc. Reports Third Quarter Results for Fiscal Year 2010 3UCI Medical Affiliates, Inc. Reports Third Quarter Results for Fiscal Year 2010 4North American Spine Welcomes Robert R. Bulger, M.D. to Dallas Physician Group 2North American Spine Welcomes Robert R. Bulger, M.D. to Dallas Physician Group 3
Inquire...
Inquire...
For use with Snap-In Snap-Out-II tip inserts. Available in five styles, the Snap-In Snap-Out-II Laparoscopic Instrument Handles offer the broadest range available....
Inquire...
Medicine Products: