Navigation Links
Tissue repair drug helps heal diabetic foot ulcers

Washington, DCPatients were twice as likely to have a diabetic foot ulcer heal within eight weeks when they were treated with a tissue repair drug versus a placebo, according to new research accepted for publication in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Foot ulcers are a common complication from diabetes than can lead to hospitalization and lower limb amputation. In 2006, about 65,700 non-traumatic lower-limb amputations were performed in people with diabetes, according to the Centers for Disease Control and Prevention. Up to 85 percent of amputations can be avoided when ulcers are prevented from forming or are treated successfully, said one of the study's authors, Francesco Squadrito, MD, of the University of Messina in Gazzi Messina, Italy.

"Foot ulcers are a dangerous and expensive complication for people with diabetes, and current treatments such as hyperbaric oxygen therapy are costly and can have side effects," Squadrito said. "Our study showed for the first time that a pharmacological approach can improve wound healing in people with diabetes."

In the prospective randomized, double-blinded, placebo-controlled clinical trial, 216 participants with diabetic foot ulcers free of visible infection were assigned to receive either the tissue repair drug polydeoxyribonucleotide (PDRN) or a placebo. Participants received injections of either PDRN or a placebo for eight weeks and were monitored for an additional four weeks for any change in the ulcer.

After two months, 37 percent of the patients who were treated with PDRN had their ulcers completely closed, compared with nearly 19 percent of the patients who received the placebo. Study subjects reported few side effects from PDRN, Squadrito said.

"This approach could revolutionize the treatment of diabetic foot ulcers a main cause of hospital admissions in the developed world," he said. "An estimated 382 million people worldwide have diabetes, and it is crucial to find effective treatment options for hard-to-heal ulcers and other complications facing millions of patients."


Contact: Jenni Glenn Gingery
The Endocrine Society

Related medicine news :

1. New study explains how dense breast tissue drives the early stages of cancer
2. New advance in 3-D printing and tissue engineering technology
3. Study identifies protein to repair damaged brain tissue in MS
4. Lab-grown, virus-free stem cells repair retinal tissue in mice
5. NIH scientists map gene changes driving tumors in common pediatric soft-tissue cancer
6. Hearing loss linked to accelerated brain tissue loss
7. Toward fixing damaged hearts through tissue engineering
8. In dyslexia, less brain tissue not to blame for reading difficulties
9. Designer swiss-army-knife molecule captures RNA in single cells in their natural tissue environment
10. Chemical imaging brings cancer tissue analysis into the digital age
11. Successful repair of bone defects using a novel tissue engineered bone graft
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... “While riding the bus, I ... Bronx, N.Y. “I thought there had to be a convenient and comfortable way to ... The PROTECTOR enables disabled individuals to safely travel during cold or inclement weather. In ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... (PHA) announces the nation’s Periwinkle Pioneers, individuals and groups responsible for advancing care ... disease. The Periwinkle Pioneers, nominated by the public, will receive special recognition throughout ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... philanthropic seniors, is resulting in a way for homeless people to have a ... have launched a new initiative whereby they are repurposing plastic bags into sleeping ...
(Date:11/25/2015)... ... November 25, 2015 , ... Since its launch in 2012, ... adult stem cell therapies to patients with chronic degenerative medical conditions. Now, the ... Registered Trademark (RTM). , Organizations are required to hold a registered trademark in ...
(Date:11/24/2015)... ... November 25, 2015 , ... Genesis Chiropractic Software ... software creates an agreement between the practice owner and the patient that automatically ... notification, and projections. Click here to learn more. , ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... FRANCISCO , Nov. 24, 2015  Thanks to ... Dignity Health St. Mary,s Medical Center,s Sister Diane Grassilli ... breast imaging capabilities in San Francisco ... an anonymous friend, stepped forward with a gift of ... for Breast Digital Mammography with Tomosynthesis and Whole Breast ...
(Date:11/24/2015)... Colo. , Nov. 24, 2015  Array ... that its Chief Executive Officer, Ron Squarer ... Healthcare Conference in New York.  The public is ... webcast on the Array BioPharma website.Event:Piper Jaffray Annual ... , Wednesday, December 2, 2015Time:1:30 p.m. Eastern Time ...
(Date:11/24/2015)... HOUSTON, TX and VANCOUVER, Nov. 24, 2015 /PRNewswire/ ... EPI; NASDAQ: EPIX ) announced today that the ... clinical study of EPI-506 as a treatment for metastatic ... States and Canada.  --> ... --> In the Phase 1/2 clinical trial, ...
Breaking Medicine Technology: