Navigation Links
Tissue engineers report knee cartilage repair success with new biomaterial
Date:1/14/2013

In a small study, researchers reported increased healthy tissue growth after surgical repair of damaged cartilage if they put a "hydrogel" scaffolding into the wound to support and nourish the healing process. The squishy hydrogel material was implanted in 15 patients during standard microfracture surgery, in which tiny holes are punched in a bone near the injured cartilage. The holes stimulate patients' own specialized stem cells to emerge from bone marrow and grow new cartilage atop the bone.

Results of the study, published in the Jan. 9 issue of Science Translational Medicine, are a proof of concept that paves the way for larger trials of the hydrogel's safety and effectiveness, the researchers say.

"Our pilot study indicates that the new implant works as well in patients as it does in the lab, so we hope it will become a routine part of care and improve healing," says Jennifer Elisseeff, Ph.D., Jules Stein Professor of Ophthalmology and director of the Johns Hopkins University School of Medicine's Translational Tissue Engineering Center (TTEC). Damage to cartilage, the tough-yet-flexible material that gives shape to ears and noses and lines the surface of joints so they can move easily, can be caused by injury, disease or faulty genes.

Microfracture is a standard of care for cartilage repair, but for holes in cartilage caused by injury, it often either fails to stimulate new cartilage growth or grows cartilage that is less hardy than the original tissue.

Tissue engineering researchers, including Elisseeff, theorized that the specialized stem cells needed a nourishing scaffold on which to grow, but demonstrating the clinical value of hydrogels has "taken a lot of time," Elisseeff says. By experimenting with various materials, her group eventually developed a promising hydrogel, and then an adhesive that could bind it to the bone.

After testing the combination for several years in the lab and in goats, with pr
'/>"/>

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. SomaLogic publishes proteomic biomarker analysis of lung cancer tissue samples
2. Mechanical tissue resuscitation technology shows promise
3. Computing the best high-resolution 3-D tissue images
4. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
5. Fertility preservation with cryopreservation of ovarian tissue: from experimental to mainstream
6. Taking tissue regeneration beyond the state-of-the-art
7. Cells derived from debrided burn tissue may be useful for tissue engineering
8. Cyborg Tissue Created Using Nano-Wires
9. Prototype represents a step toward enhanced soft-tissue tomography
10. Analyzing the Facebook Effect on organ and tissue donation
11. Tissue around tumor holds key to fighting triple negative breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... 12, 2014 Tylenol lawsuits ( ... move forward in the federal multidistrict litigation underway ... Bernstein Liebhard LLP reports. According to a filing ... F. Stengel has ordered the deposition of a ... found that the witness’s testimony concerning the marketing ...
(Date:7/12/2014)... -- Burn injuries increase in the summer as people gather ... Among those most vulnerable to these seasonal fire hazards: children. ... get burned by putting their hands on the side of ... unit at Loyola University Medical Center in Maywood, Ill., said ... ,When you play with fire, you get burned, is true ...
(Date:7/12/2014)... 12, 2014 “After my mom’s stroke, she loss ... stroke and loss the use of his left side. Eating became ... way to help people like them enjoy eating again,” said an ... for the PATRICIA CAROL HALL PLATE (P C H PLATE). , ... more ergonomic way to eat for individuals who suffer from stroke, ...
(Date:7/12/2014)... prom shopping reaching its final days, VogueQueen.com, a renowned ... its new and trendy apparels. Recently, the company has ... online shop. Additionally, it is now providing huge discounts ... to the company’s sales manager, the promotion will come ... He says, “Now, worldwide clients can order cheap ...
(Date:7/12/2014)... “Critical Care Therapeutics in Major Developed ... PCCs and Recombinant Products to Drive Market,” which ... in the US, UK, France, Germany, Italy, Spain, ... of market size for 2013, along with market ... that are being treated using the five major ...
Breaking Medicine News(10 mins):Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 2Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 3Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 4Health News:Burn Injuries More Common in Summer 2Health News:VogueQueen.com Updates Its Summer Collection With New And Trendy Evening Dresses 2Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 2Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 3Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 4Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 5Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 6
... One way to respond to this is to blame the victimto ... another common response, according to a new study published in ... The researchers found that people who believe in justice in the ... meaning. "A lot of the time when people see ...
... (BUSM) have been awarded a five-year, $2 million grant ... Network (EDRN), as well as a four-year, $1.3 million ... will allow the scientists to develop novel and complementary ... patients. The grant from NCI will support ...
... in French . , MONTREAL, December 14, 2010 ... babies learn to recognize the sound of their parents, voice and ... between parents and newborns admitted to the intensive care unit can ... relationship. , Jan Lariviere, a nurse in the neonatal clinic and ...
... TUESDAY, Dec. 14 (HealthDay News) -- Prayer can help ... emotions by using coping methods such as venting, a ... people in abusive relationships who were interviewed by Shane ... Wisconsin, Madison. The racially diverse participants came from different ...
... , TUESDAY, Dec. 14 (HealthDay News) -- Most of the ... is funded by states, not the federal government, a new ... the extent to which states prioritized human embryonic stem cell ... could likely have been funded under federal government guidelines established ...
... collaboration between researchers at the Salk Institute for Biological ... the tumor suppressor p53, long thought of as the ... cancer-causing mutations. It may also prevent established cancer cells ... serving as a "Guardian against Genome Reprogramming." The ...
Cached Medicine News:Health News:People who believe in justice also see a victim's life as more meaningful after tragedy 2Health News:Boston University School of Medicine awarded grants to improve early detection of lung cancer 2Health News:Once upon a time in the Intensive Care Unit ... 2Health News:Prayer May Help Victims of Domestic Abuse 2Health News:States Now Fund Most Embryonic Stem Cell Research in U.S. 2Health News:The stemness of cancer cells 2Health News:The stemness of cancer cells 3
(Date:7/11/2014)... July 11, 2014 Research and Markets ... Needles Market 2014-2018" report to their offering. ... hypodermic needle is a hollow needle commonly used with ... or to extract fluids from it. A hypodermic needle ... inject substances that cannot be ingested. Hypodermic needles are ...
(Date:7/11/2014)... , July 11, 2014 ... Market Research "Endoscopy Devices Market (Endoscopes, Endoscopic Operative Devices, ... Growth, Trends and Forecast, 2013-2019" the global endoscopy devices ... and is expected to grow at a CAGR of ... value of USD 36.9 billion in 2019. ...
(Date:7/11/2014)... Neurelis, Inc. ("Neurelis") today announced an agreement ... held by Biotie to purchase Neurelis, clearing the way ... diazepam) for pediatric and adult epilepsy patients who experience ... Biotie has advanced the development program for NRL-1 and ... work required for NDA submission to the FDA.  Given ...
Breaking Medicine Technology:Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6Neurelis Regains Rights to Intranasal Diazepam Program 2Neurelis Regains Rights to Intranasal Diazepam Program 3
Livewire TC steerable ablation catheters are designed for the RF ablation of arrhythmias. They are available in a variety of curves and configurations, including bi-directional catheters for added fl...
Trilogy Pacemakers incorporates the clinically proven Omniscence™ accelerometer sensor with it's automatic alogorithms. The Trilogy family of pacemakers feature an array of products for bradyar...
... The Integrity ADx pacemaker ... world's smallest dual-chamber pacemaker, ... pacemaker technology, including the ... the first U.S. commercially ...
... The Frontier II device ... symptoms of moderate to severe ... or IV) in patients who ... medical therapy and who have ...
Medicine Products: