Navigation Links
Tips from the journals of the American Society for Microbiology
Date:8/15/2011

Breast Cancer Tumor Suppressor Gene Silenced by Low O2

Low oxygen can silence the BRCA1 tumor suppressor gene and contribute to the progression of cancer, according to a paper in the August 2011 issue of the journal Molecular and Cellular Biology. Silencing this particular gene is one of the steps on the malignant pathway to breast cancer. The research may ultimately lead to ways of reactivating this and other tumor suppressor genes, in order to thwart cancer, says corresponding author Peter Glazer of Yale University, New Haven.

This study grew out of Glazer's laboratory's previous findings that low oxygen stress to cells can cause changes in expression of many human genes, sometimes boosting, and sometimes reducing expression. "We had found a few years ago that hypoxia reduces expression of BRCA1, and so I had the idea to ask whether it could drive silencing of the gene," says Glazer.

Hypoxia is common in human tumors, partly because newly emerging tumors lack blood vessels. "They become hypoxic because they don't get enough blood," says Glazer. As they enlarge, they begin to grow blood vessels, in a process known as angiogenesis. But "that process is never perfect, so tumors have a very variable and incomplete blood supply," says Glazer. "That makes them more genetically unstable, and helps drive them towards more malignant properties," he adds, citing earlier work by his laboratory.

The silencing could be a first step towards cancer, but Glazer thinks it more likely is a later step, since without the tumor, the hypoxia that drives gene silencing is less likely to occur, says Glazer.

Understanding the mechanism of reduced expression would open the way to research that could lead to strategies for interfering with the gene silencing. What we know so far: the mechanism for the silencing involves the histones, proteins that wrap around the chromosomes when they are silent, but which unwrap around ge
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. Over 40 new titles added to Wiley-Blackwells journals program in 2011
2. New study: Serious gaps in medical journals disclosure of physician relationships with industry
3. CONSORT 2010: Leading journals publish new guidelines to improve trial reports
4. Bad Economic News Taking Toll on Americans Emotions
5. More American Kids Eating Fast Food
6. Americans Use of Antidepressants On the Rise: Study
7. Americans No Longer Outliving Europeans: Study
8. Effects of tobacco use among rural African American young adult males
9. Painful Gout Afflicting More Americans: Study
10. Americans Show Rising Support for Abortion Rights: Poll
11. New data-based strategies and treatment models can improve diabetes care for older African-Americans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... Randy Dotinga ... News) -- When most children take on a task, ... of this neuro-boosting activity in kids with autism, according ... more severe symptoms of autism displayed even less of ... ,"This reduced flexibility often causes difficulty when children with ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 The Board of ... Holland & Hart LLP ’s Connie Akridge to ... currently serves as President of the Foundation. Akridge served as ... Akridge is a partner at Holland & Hart in Las ... and regulatory/administrative matters to insurance and healthcare clients for more ...
(Date:7/29/2014)... Washington D.C. (PRWEB) July 29, 2014 ... spending in Medicare Part D by a projected $2.9 ... report by the actuarial firm Milliman released today by ... average Part D premiums could increase by as much ... high-priced hepatitis C drugs, including Sovaldi and Olysio. , ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 The Law Offices ... Stepping Stones of Hope, a non-profit organization providing grief camps ... hand the anguish and suffering our clients experience from the ... desire to support an organization like Stepping Stones of Hope, ... grief. , Stepping Stones of Hope also includes a monthly ...
(Date:7/29/2014)... record the severity and regularity of their pain is ... , A new approach to the treatment of headaches, ... and is being led by Professor Paul Martin from ... He has developed an approach designed to enable people ... Learning to Cope with Triggers (LCT). , Using a ...
Breaking Medicine News(10 mins):Health News:Less Flexibility Seen in Brain Wiring of Kids With Autism: Study 2Health News:Less Flexibility Seen in Brain Wiring of Kids With Autism: Study 3Health News:Holland & Hart LLP Attorney Connie Akridge Reappointed Trustee of the Nevada Bar Foundation 2Health News:New Milliman Study: Hepatitis C Drugs Could Increase Medicare Part D Spending by $2.9 to $5.8 Billion in 2015 2Health News:The Law Offices of Michael Cordova is Sponsoring Stepping Stones of Hope, a Non-Profit Organization Providing Grief Camps for Kids, Teens, Adults, and Families 2
... Nov. 2 The National Alliance of Wound Care ... organization, announced today, the launch of their wound care ... newly redesigned website at, www.nawccb.org ... support our nearly 8000 certified wound care professionals with ...
... ... manufacturer of custom printer solutions, is expanding operations in the U.S. Martel provides custom ... and retail point of sale equipment. Martel,s customers in the U.S. include Abbott Laboratories. ... (PRWEB) November ...
... ... 2010 is for healthcare providers as a no-surgery and no-device alternative for sleep apnea ... with surgery and CPAP or any oral devices. , ... Hanover Park, IL (PRWEB) November 2, 2009 -- ...
... STANDUP FOR KIDS has been chosen by STAR OF ... are being asked to join forces for charity ... November,s National Homeless Youth Awareness Month. Local business owners ... THE NEIGHBORHOOD, are displaying posters and encouraging their customers to ...
... Polymer Group, Inc. (OTC Bulletin Board: POLGA; POLGB) (PGI) ... acquire the Barcelona, Spain-based Tesalca-Texnovo nonwovens businesses from Grupo ... expected to close by the end of November, subject ... http://www.newscom.com/cgi-bin/prnh/20080903/CLW036LOGO-b ) , In conjunction with the ...
... BOSTON, Nov. 1 Schering-Plough Corporation (NYSE: SGP ... therapy with boceprevir combination therapy in patients with chronic ... analyses were presented at the American Association for the ... Oct. 30-Nov. 3. , Boceprevir is an ...
Cached Medicine News:Health News:National Alliance of Wound Care(R) Launches On-line Job Resource Center and New Website 2Health News:Martel Instruments Expands Its Custom Printer Solutions Business in North America; Liz Peirce Named Director of North American Business Development 2Health News:SleepApneaUSA.net Announced New 2010 ZHT (Zhou's Hypoxicology Therapy) Certification Class For Sleep Apnea As A No-Surgery And No-Device Alternative 2Health News:SleepApneaUSA.net Announced New 2010 ZHT (Zhou's Hypoxicology Therapy) Certification Class For Sleep Apnea As A No-Surgery And No-Device Alternative 3Health News:SleepApneaUSA.net Announced New 2010 ZHT (Zhou's Hypoxicology Therapy) Certification Class For Sleep Apnea As A No-Surgery And No-Device Alternative 4Health News:Local Businesses Unite, Calling an End to Youth Homelessness 2Health News:PGI Signs Agreement to Acquire Spanish Nonwovens Business Tesalca-Texnovo 2Health News:PGI Signs Agreement to Acquire Spanish Nonwovens Business Tesalca-Texnovo 3Health News:PGI Signs Agreement to Acquire Spanish Nonwovens Business Tesalca-Texnovo 4Health News:Data Supporting Boceprevir Response Guided Therapy Presented at American Association for the Study of Liver Diseases (AASLD) Annual Meeting 2Health News:Data Supporting Boceprevir Response Guided Therapy Presented at American Association for the Study of Liver Diseases (AASLD) Annual Meeting 3Health News:Data Supporting Boceprevir Response Guided Therapy Presented at American Association for the Study of Liver Diseases (AASLD) Annual Meeting 4Health News:Data Supporting Boceprevir Response Guided Therapy Presented at American Association for the Study of Liver Diseases (AASLD) Annual Meeting 5Health News:Data Supporting Boceprevir Response Guided Therapy Presented at American Association for the Study of Liver Diseases (AASLD) Annual Meeting 6Health News:Data Supporting Boceprevir Response Guided Therapy Presented at American Association for the Study of Liver Diseases (AASLD) Annual Meeting 7Health News:Data Supporting Boceprevir Response Guided Therapy Presented at American Association for the Study of Liver Diseases (AASLD) Annual Meeting 8Health News:Data Supporting Boceprevir Response Guided Therapy Presented at American Association for the Study of Liver Diseases (AASLD) Annual Meeting 9Health News:Data Supporting Boceprevir Response Guided Therapy Presented at American Association for the Study of Liver Diseases (AASLD) Annual Meeting 10Health News:Data Supporting Boceprevir Response Guided Therapy Presented at American Association for the Study of Liver Diseases (AASLD) Annual Meeting 11
(Date:7/29/2014)... , July 29, 2014 /PRNewswire-iReach/ -- MHG ... provider, has launched its Medical Equipment and ...  These services are tailored to the cruise industry,s ... prompted industry operators to propose that they should ... Medical,s new program is intended to create standardized ...
(Date:7/29/2014)... July 29, 2014 According to ... "Orthopedic Trauma Fixation Devices Market - Global Forecast, Market ... the global orthopedic trauma fixation devices market is estimated ... to grow at a CAGR of 7.2% from 2014 ... 9.3 billion in 2020. Browse the Orthopedic ...
(Date:7/29/2014)... LAKE CITY and ... -- EastGate Acquisitions Corporation (OTCBB: ESAQ), an ... in the development of improved novel formulations ... active molecules announces expansion of its pharmaceutical ... new development direction includes large molecule drugs that ...
Breaking Medicine Technology:MHG Medical Management Services Aims to Change Cruise Industry Standard With New Equipment Maintenance Program 2Orthopedic Trauma Fixation Devices Market is Expected to Reach USD 9.3 Billion Globally in 2020: Transparency Market Research 2Orthopedic Trauma Fixation Devices Market is Expected to Reach USD 9.3 Billion Globally in 2020: Transparency Market Research 3Orthopedic Trauma Fixation Devices Market is Expected to Reach USD 9.3 Billion Globally in 2020: Transparency Market Research 4EastGate Acquisitions Announces Expansion of its Pharmaceutical Developments Implementing its Sub-Micron Platform Technology 2EastGate Acquisitions Announces Expansion of its Pharmaceutical Developments Implementing its Sub-Micron Platform Technology 3EastGate Acquisitions Announces Expansion of its Pharmaceutical Developments Implementing its Sub-Micron Platform Technology 4
... 13, 2011 CVS Caremark Corporation (NYSE: ... president and chief financial officer of CVS Caremark, will ... 2011 Global Consumer Conference on June 22, 2011. Mr. ... (Logo: http://photos.prnewswire.com/prnh/20090226/NE75914LOGO ) An ...
... 13, 2011 AmbiCom Holdings, Inc. (OTCQB: ABHI), a ... equipment suppliers, today announced that it has signed an ... Technology, Inc. ("ATI") subsidiary and E-Care Technology Corporation, ("ECT") ... runs for a period of three years. ...
Cached Medicine Technology:CVS Caremark to Present at the Jefferies 2011 Global Consumer Conference 2AmbiCom Forms Joint Alliance With E-Care Technology Corporation 2AmbiCom Forms Joint Alliance With E-Care Technology Corporation 3
Each handle is designed to fit a specific trephine size....
Each handle is designed to fit a specific trephine size....
Each handle is designed to fit a specific trephine size....
20 GA TITANIUM RETINAL FORCEPS...
Medicine Products: