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Tips from the American Journal of Pathology
Date:8/26/2009

u-long Huang at the University of Texas Southwestern Medical Center in Dallas, Texas have discovered that the protein Wnk1 (with-no-lysine (K)-1) is critical in angiogenesis and heart development. They present these findings in the September 2009 issue of the American Journal of Pathology.

Angiogenesis is the formation of blood vessels in organs. However, the molecular mechanisms that regulate blood vessel and heart development, particularly the differentiation of arteries and veins, remain unclear.

Wnk1 is required for normal development; yet, its role in vascular development remains poorly characterized. Xie et al therefore examined cardiovascular development in mice that did not express Wnk1. These Wnk1-null mice displayed defective heart development. In addition, Wnk1-deficiency resulted in an angiogenic defect in blood vessels, with altered expression of markers of both arteries and veins. These defects were specific to endothelial Wnk1 expression. Thus, endothelial Wnk1 is critical for angiogenesis and cardiac development and may contribute to arterial-venous differentiation.

This study by Xie et al "provide[s] strong evidence suggesting that function of WNK1 in endothelial cells defines a novel pathway or mechanism in the determination and/or maintenance of arterial-venous identity and is essential for embryonic cardiac development."

Xie J, Wu T, Xu K, Huang IK, Cleaver O, Huang C-l: Endothelial-specific Expression of WNK1 Kinase Is Essential for Angiogenesis and Heart Development in Mice. Am J Pathol 2009, 175: 1315-1327

Drug Abuse Worsens HIV-Associated Neurocognitive Disorders (HANDs)

Researchers led by Dr. Joan Berman at the Albert Einstein School of Medicine in New York, NY have found that drug abuse increases the severity of HANDs through dopamine signaling. They report their data in the September 2009 issue of the American Journal of Pathology.

HANDs is a neuro
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Contact: Angela Colmone
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

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