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Tiny piece of RNA keeps 'clock' running in earliest stages of life
Date:3/11/2013

y don't actually help with protein production.

The researchers used multiple techniques to block mir-125a-5p in chicken embryos as the segmentation clock was running, either blocking all activity of the microRNA or interfering with its ability to bind with RNA encoded by the Lfng gene.

"When the clock doesn't oscillate the cells don't make nice, regular somites, but instead make nothing or partially formed somites," Cole said. "This has really important applications for the mechanisms that control the clock, and could gives us hints about how the timeframe of this clock varies from species to species."

In chickens, each somite forms in 90 minutes. In zebrafish, it takes 30 minutes, while in mice each somite forms in two hours and in humans, five hours.

Cole also plans to study how this regulation occurs in mammals and whether this microRNA's interaction with Lfng is involved in disease processes affected by this gene.


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Contact: Susan Cole
Cole.354@osu.edu
614-292-3276
Ohio State University
Source:Eurekalert

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