Navigation Links
Tiny piece of RNA keeps 'clock' running in earliest stages of life
Date:3/11/2013

COLUMBUS, Ohio New research shows that a tiny piece of RNA has an essential role in ensuring that embryonic tissue segments form properly.

The study, conducted in chicken embryos, determined that this piece of RNA regulates cyclical gene activity that defines the timing of the formation of tissue segments that later become muscle and vertebrae.

Genes involved in this activity are turned on and off in an oscillating pattern that matches the formation of each tissue segment. If the timing of these genes' activity doesn't remain tightly regulated, the tissue either won't form at all or will form with defects.

One gene long associated with this segmentation "clock" is called Lfng. Researchers established in this study that a single microRNA a tiny segment of RNA that has no role in producing any protein is key to turning off Lfng at precisely the right time as tissues form in this oscillating pattern.

When the microRNA was deleted or manipulated so that it wouldn't bind when it was supposed to, the oscillatory pattern of the genetic clock was broken and tissue development was abnormal.

"It's a big deal to find that a single interaction between a microRNA and its target has this very profound effect when you interfere with its function," said Susan Cole, associate professor of molecular genetics at The Ohio State University and lead author of the study. "There are very few cases where interfering with just one microRNA during development can make this much of a difference. But here, this regulation is so tight that this turns out to be incredibly important.

"We don't think this is exclusive to chickens because the site where the microRNA binds to the RNA segment produced by Lfng is found in chickens, humans, mice and zebrafish."

A better understanding of these segmentation clocks could lead to new ways to treat certain human conditions that are traced to embryonic development. Defects in the clock are
'/>"/>

Contact: Susan Cole
Cole.354@osu.edu
614-292-3276
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. A Piece of Family Tradition Found In Every Bar of Soap - An Ancient Family Recipe from Mexico Inspires the Launch of Montes Botanicals Bath & Body
2. Snoring Mouthpiece by VitalSleep Helps Accomplish New Year’s Resolution to Kick Snoring Habits
3. Turning off key piece of genetic coding eliminates toxic effect of statins, SLU research finds
4. Cost of Diabetes Care in U.S. Keeps Climbing
5. Package All Corporation Keeps on Growing with Expanded Distribution Centers and Services to Keep Customers' Packaging Lines Moving
6. Copper depletion therapy keeps high-risk triple-negative breast cancer at bay
7. New Weber Denture Liner Keeps Loose Dentures in Place
8. Heres What Keeps Rudolphs Nose So Bright
9. Funding Meals on Wheels Keeps Seniors Independent: Study
10. What keeps a cells energy source going
11. Oxytocin keeps flirting folks at arms length
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... DW-InductionHeating.com (DaWei Induction Heating Co.) is a comprehensive high-tech ... marketing of a series of induction heating equipment. Today, ... of induction brazing equipments . , According to ... refers to the joining of two or more ... manager says that there are fundamental differences in the ...
(Date:12/25/2014)... 26, 2014 This is a professional ... global Sterilizers industry with a focus on the Chinese ... status of the Sterilizers manufacturers and is a valuable ... interested in the industry. This report provides a basic ... manufacturing technology. In this part, the report presents the ...
(Date:12/25/2014)... The report “TS-1 (Colorectal Cancer) – Forecast and ... landscape, unmet needs, current pipeline and commercial opportunities in ... which is typically used for treating colorectal cancer. It ... gastric cancer and pancreatic cancer. TS-1 is composed of ... approved in 1999 in Japan for the treatment of ...
(Date:12/25/2014)... December 26, 2014 Recently, iFitDress.com, the popular ... women, has announced its new selection of black one-shoulder ... on sale now; they are available at discounted prices, up ... “The promotion will last for three weeks only. You know, ... Those who are interested in our new items can visit ...
(Date:12/25/2014)... Recently, BellasDress has launched its Christmas ... BellasDress has chosen their best-selling lace wedding dresses, vintage ... holiday season. , Now, BellasDress.com features popular women’s ... at discount prices. The business hopes everyone can have ... , “All our elegant products are made with ...
Breaking Medicine News(10 mins):Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 3Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2
... treatment failure in more than 90 percent of metastatic ... rates. Dean Ho, an associate professor of ... a tiny carbon particle called a nanodiamond may offer ... In studies of liver and breast cancer models in ...
... Institute of Technology have found support for the theory that ... it stores readily available items. Memory researchers have long debated ... capacity and function of each layer is. In a ... Cognitive Psychology, researchers found that short-term memory is made ...
... Ortega, MD, an anesthesiologist at Boston Medical Center (BMC) ... of Medicine (BUSM), received a Letter of Commendation from ... video on pulse oximetry. The video, which has been ... a major component of the WHO,s efforts to improve ...
... Maureen Salamon HealthDay Reporter , WEDNESDAY, March ... and family life, fueled by constant availability via cell ... women, a new study finds. Researchers from the ... American workers to determine gender differences in how men ...
... with taking aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) ... of elevations in a particular inflammatory factor in the ... of Gastroenterology , investigators from Massachusetts General Hospital ... baseline levels of a novel inflammatory marker indicated increased ...
... 100 million Americans may currently be misclassified as having ... the Veterans Affairs Health Care System in Minneapolis and ... show that these people are not actually more likely ... i.e. below 120/80. Taylor and colleagues, article in the ...
Cached Medicine News:Health News:Tiny gems take big step toward battling cancer 2Health News:New study proves the brain has 3 layers of working memory 2Health News:BMC doctor recognized by World Health Organization for pulse oximetry training video 2Health News:Women Feel More Guilt, Distress About Work Intrusions at Home, Study Says 2Health News:Women Feel More Guilt, Distress About Work Intrusions at Home, Study Says 3Health News:Aspirin's ability to protect against colorectal cancer may depend on inflammatory pathways 2Health News:Redefining normal blood pressure 2
(Date:12/24/2014)... -- Kinex Pharmaceuticals announced today that the first patient ... Institute. KX2-361 (KX02), a dual src/pre-tubulin inhibitor, ... inhibitory activity against a broad panel of brain tumor ... (T98G), the most widely used chemotherapy for the treatment ... model, KX2-361 consistently clears brain tumors after 4 weeks ...
(Date:12/24/2014)... and FARMINGTON, Conn. , Dec. ... MKT: PTN), a biopharmaceutical company developing targeted, receptor-specific ... significant unmet medical need and commercial potential, today ... placement of 2,050,000 shares of its common stock ... of its common stock.  Funds under the management ...
(Date:12/24/2014)... -- ResMed (NYSE: RMD ) today announced its ... device manufacturer BMC Medical Co., Ltd. The ... below infringe ResMed,s patents, and entered an order prohibiting BMC ... the United States : , iVolve nasal ... nasal pillows mask , iVolve full face mask ...
Breaking Medicine Technology:Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 2Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 4ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2
... , STUART, Fla., ... is pleased to announce the addition of Mr. Joseph Farish and ... is s graduate of the University of Florida (Bachelor of Arts ... been a member of the Florida Bar for more than 59 ...
... LONDON and PHILADELPHIA, Dec. 11 In a ... experienced a median survival of 14 months when treated with ... results of the Phase III study in HER2-positive metastatic breast ... Breast Cancer Symposium, held in San Antonio, Texas (Dec. 9 ...
Cached Medicine Technology:Liberator Medical Strengthens its Board of Directors with the Addition of Mr. Joseph Farish and Mr. Robert S. Cuillo 2Liberator Medical Strengthens its Board of Directors with the Addition of Mr. Joseph Farish and Mr. Robert S. Cuillo 3Liberator Medical Strengthens its Board of Directors with the Addition of Mr. Joseph Farish and Mr. Robert S. Cuillo 4GSK Study Showed Targeted Therapy Combination Achieved 14 Month Overall Survival in Patients with Advanced Breast Cancer 2GSK Study Showed Targeted Therapy Combination Achieved 14 Month Overall Survival in Patients with Advanced Breast Cancer 3GSK Study Showed Targeted Therapy Combination Achieved 14 Month Overall Survival in Patients with Advanced Breast Cancer 4GSK Study Showed Targeted Therapy Combination Achieved 14 Month Overall Survival in Patients with Advanced Breast Cancer 5GSK Study Showed Targeted Therapy Combination Achieved 14 Month Overall Survival in Patients with Advanced Breast Cancer 6
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: