Navigation Links
Tiny molecule helps control blood-vessel development, UT Southwestern researchers find
Date:8/12/2008

DALLAS Aug. 12, 2008 The development and repair of heart tissue and blood vessels is intimately tied to a tiny piece of ribonucleic acid (RNA) that is found nowhere else in the body, researchers at UT Southwestern Medical Center have found.

Because of its specificity to the cardiovascular system, this "microRNA" is an attractive potential target for therapeutic treatment, the researchers said.

"Manipulating this microRNA provides a completely new way of addressing cardiovascular disorders," said Dr. Eric Olson, chairman of molecular biology and senior author of a study appearing in today's issue of Developmental Cell.

MicroRNAs are tiny snippets of genetic material, naturally produced by the body, that help fine-tune the production of proteins by DNA. More than 500 have already been identified.

In the current study, the researchers focused on a specific microRNA called miR-126, which was already known to be associated with blood vessels. They found that miR-126 is found only in a class of cells called endothelial cells, which line the inside surfaces of blood vessels.

Endothelial cells control the development of new blood vessels in developing embryos; the repair of injured blood vessels; and the creation of blood vessels to support developing tumors.

The researchers genetically engineered mice to lack miR-126, and found that about 40 percent of them died before or just after birth. These mice showed cardiovascular abnormalities such as fragile, leaking blood vessels.

The surviving mice, however, appeared normal and lived to adulthood. The researchers concluded that miR-126 is important in creating new vessels, but once the cardiovascular system is established, it is not needed to maintain the system.

However, the surviving mice were less able to recover from a simulated heart attack. Almost all mice lacking miR-126 died within three weeks, while 70 percent of normal mice su
'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. New class of RNA molecules may be important in human cancer
2. Molecule Promising Against Huntingtons Disease
3. Free Access to Literature Data on Chagas Disease Offered Online: Collaborative Drug Discovery, Inc. provides Neglected Disease researchers with archive mine and collaborate access to small molecule bioactivity SAR data on parasitic disease
4. Vulnerability to Stress Linked to Brain Molecule
5. Amira Pharmaceuticals Announces Favorable Phase 1 Clinical Trial Results for Lead Product Candidate AM103 and Initiates Clinical Studies for the 2nd Entry Molecule for the Treatment of Respiratory and Cardiovascular Disease
6. Study Describes Molecules That Control Blood Pressure
7. Researchers identify molecules with interesting anti-clotting properties
8. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
9. St. Jude finds molecule that could improve cancer vaccines and therapy for other diseases
10. Major Advance in the Observation of DNA Molecules
11. Molecules can block breast cancers ability to spread
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tiny molecule helps control blood-vessel development, UT Southwestern researchers find
(Date:12/26/2014)... Yisrayl Hawkins, Pastor at The House of ... light of the Ferguson, Missouri unrest. Yisrayl starts his letter ... explains why it has only increased. , He continues ... He says there is a very specific reason for mankind ... is a set of rules, or Laws that if followed ...
(Date:12/26/2014)... 2014 India Network Foundation, a non-profit ... USA, announced today a new version of “ EasySelect ... the right plan for their visiting parents. The technology ... the selection process when choosing an insurance plan by ... only a few clicks. Many elderly Asian Indian parents ...
(Date:12/25/2014)... December 26, 2014 The microscopy ... of 7.2% to reach $5,756.0 million by 2019. ... microscopy market. The electron microscopes product segment is ... forecast period. , Rising focus on nanotechnology, technological ... of the microscopy market. , Get Full Copy ...
(Date:12/25/2014)... Dallas, TX (PRWEB) December 26, 2014 ... Analysis to 2023” focuses on the current treatment landscape, ... colorectal cancer market. TS-1 is an anti-cancer drug which ... administered orally and is also used for treating gastric ... gimestat and otastat potassium. The drug was first approved ...
(Date:12/25/2014)... (PRWEB) December 26, 2014 Recently, Dylan ... dresses, has excitedly released its collection of discounted prom ... to Percy, a senior spokesman of the company, the ... of this promotion is to expand the UK market. ... in several different colors, lengths, and styles: A-line strapless, ...
Breaking Medicine News(10 mins):Health News:Yisrayl Hawkins Pleads for Peace in Ferguson and Beyond in New Open Letter 2Health News:India Network Health Insurance Announces new Comprehensive Pre-existing Condition Coverage policy for Visitors to the United States 2Health News:India Network Health Insurance Announces new Comprehensive Pre-existing Condition Coverage policy for Visitors to the United States 3Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 3Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 4Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2
... People undergoing bisphosphonate therapy to prevent or treat osteoporosis ... drug and possible adverse side effects on oral health, according ... Journal of the American Dental Association (JADA). , Use ... developing bisphosphonate-associated osteonecrosis of the jaw (BON) that occurs spontaneously ...
... ... Respect™ Medical Center in the Anti-Defamation League’s (ADL’s) Southwest Region. , ... Houston, TX (Vocus) ... of Respect™ Medical Center in the Anti-Defamation League’s (ADL’s) Southwest Region. The Community ...
... ... one option for addressing health reform’s new medication waste reduction mandates , ... Phoenix, AZ (PRWEB) May 26, ... its world-class software and proven hardware components to enhance efficiency, provide greater inventory control, ...
... ... to $100,000 per-violation penalties , ... Alexandria, VA (Vocus) May 26, 2010 -- More than ten major retailers, ... (CEN) offered by the National Association of Chain Drug Stores (NACDS) and RollStream. ...
... is female sterilization, study shows , WEDNESDAY, May 26 (HealthDay ... after it was invented, the oral contraceptive remains the leading ... report says, just edging out female sterilization. , Interviews ... aged 15-44 were using the birth-control pill, while 10.3 million ...
... July 2010, Stockholm, Sweden, Stockholm International Fair and Congress ... a major risk factor for several chronic diseases, including ... of the leading preventable causes of death worldwide. The ... health challenges of the 21st century. The ...
Cached Medicine News:Health News:Some bisphosphonates users unfamiliar with drug's possible side effects on oral health 2Health News:Houston Northwest Medical Center Becomes First Hospital in the Southwest Region Designated a Community of Respect™ Partner 2Health News:Talyst Reaches Major Milestone: 500 Implementations in Long-Term Care, Acute Care and Corrections 2Health News:Talyst Reaches Major Milestone: 500 Implementations in Long-Term Care, Acute Care and Corrections 3Health News:Retailers and Manufacturers Quickly Adopt Online Network to Address CPSIA Compliance 2Health News:Retailers and Manufacturers Quickly Adopt Online Network to Address CPSIA Compliance 3Health News:Media arrangements for the International Congress on Obesity 2
(Date:12/24/2014)... 2014  Advanced Medical Isotope Corporation ("AMIC") (OTCQB: ADMD), ... the development of brachytherapy devices and medical isotopes ... it has filed a de novo ... for marketing clearance for its patented Y-90 RadioGel(TM) ... Food, Drug and Cosmetic Act (the "Act").  ...
(Date:12/24/2014)... , Dec. 23, 2014  Lockton Dunning Benefits, ... Lockton Companies, announced the addition of Vice President ... join Lockton Dunning,s Pharmacy Consulting team, Excelsior Solutions. ... relevant industry experience to the position.  Most recently, ... Sales at Diplomat Specialty Pharmacy, where she has ...
(Date:12/24/2014)... 23, 2014  Medical Science Liaisons play a large ... between the medical device industry and key stakeholders, the ... coming years as the device industry relies on them ... research by benchmarking firm, Best Practices, LLC, one area ... edge is by harnessing new technology to enable education. ...
Breaking Medicine Technology:Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 2Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 3Kim Foerster Joins Lockton Companies 2Role of Medical Science Liaisons Evolving in Medical Device Sector 2
... Spine, LLC, today announced that the InterPlate® C-Ti has been ... devices occurred in 2007, the C-Ti was the first system ... this most recent announcement, the C-Ti has now become the ... cervical plate as well. , RSB Spine Chief Executive Officer ...
... , MIAMI, Oct. 12 AvMed Health Plans ... all of its fully insured members. Co-pays, co-insurance and deductibles ... if they have a benefit plan that does not include ... well-being of our members and we want to ensure that ...
Cached Medicine Technology:AvMed Covers H1N1 Flu Vaccine For Members 2
... to adults, the entire series of time-tested ... of the needs of care providers and ... the accuracy. You can see it in ... the performance, year after year. Every Timeter® ...
The Soft-Touch Timeter® Flowmeter is durable, long-lasting and easy to maintain. Timeter ® by Allied Flowmeters: Quality Plus Value....
The Soft-Touch Timeter® Flowmeter is durable, long-lasting and easy to maintain. Timeter ® by Allied Flowmeters: Quality Plus Value....
The Soft-Touch Timeter® Flowmeter is durable, long-lasting and easy to maintain. Timeter ® by Allied Flowmeters: Quality Plus Value....
Medicine Products: