Navigation Links
Tiny implanted coil improves lung function in patients with severe emphysema
Date:5/23/2012

ATS 2012, SAN FRANCISCO A tiny, resilient metal wire designed to gather and compress diseased lung tissue may offer relief to patients with severe heterogeneous emphysema, a subtype of the disease that involves specific, usually isolated areas of the lungs, according to the results of a multicenter international trial conducted in the Netherlands, Germany and France. The wire, called a lung volume reduction coil (LVRC), can be easily implanted and is designed to take the place of more invasive procedures used to improve the lung function of emphysema patients.

The study will be presented at the ATS 2012 International Conference in San Francisco.

"Our results indicate that LVRC treatment is technically feasible in both upper and lower regions of the lung in patients with severe heterogeneous emphysema, and results in significant improvements in pulmonary function, exercise capacity and quality of life, with an acceptable safety profile," said study lead author Dirk-Jan Slebos, MD, pulmonary physician at the University Medical Center Groningen (UMCG), The Netherlands.

Lung volume reduction is performed in patients with emphysema in an effort to isolate diseased lung tissue and allow healthy lung tissue to expand and function more efficiently, which in turn helps the patient to breathe and function better. Because heterogeneous emphysema involves different areas, or lobes, of the lung, surgery to contain diseased lung tissue can be complicated and extensive. Use of wire coils, which can be implanted in relatively noninvasive bronchoscopic procedures, is emerging as a more effective, and safer, option than surgery for these patients. Coils are compressed during implantation, and expand to their original shape once implanted in the lung tissue.

Although a previous single-center trial showed LVRC to be safe and effective in patients with severe upper-lobe emphysema, Dr. Slebos said this study involved patients treated at 11 different healthcare centers, and explored the safety, efficacy and feasibility of LVRC in both upper and lower lobes.

The study enrolled 53 patients who underwent 101 LVRC procedures, including 46 bilateral (both lungs) procedures and nine unilateral procedures. In each procedure, the clinicians implanted from eight to 14 coils, resulting in a study total of 1,070 coils being implanted. Safety was evaluated by recording all adverse events that occurred within the first 30 days following treatment, as well as those that occurred between 30 days and six months of treatment. Efficacy was measured by quality-of-life questionnaires, pulmonary function testing and exercise testing, all performed six months following treatment. Reported adverse events included exacerbation of chronic obstructive pulmonary disease (COPD), pneumonia, collapsed lung, chest pain and mild hemoptysis, or coughing up blood, which could be managed with standard care.

The researchers found that LVRC treatment resulted in significant improvement in respiratory measurements at six months, especially in patients whose lungs were severely hyperinflated. In this group, LVRC therapy resulted in significant improvements in lung function, hyperinflation, exercise capacity and quality of life measurements. In fact, severe hyperinflation at baseline appeared to be an indicator of better outcomes, Dr. Slebos noted.

"Hyperinflation of lung tissue is one of the key pathophysiological features of emphysema that is responsible for shortness of breath, and its magnitude seems to be a good indicator of successful LVRC treatment," he said.

Dr. Slebos said the trial is ongoing and continues to collect data.

"The results so far indicate that the LVRC is a safe and effective choice for treating patients with severe heterogeneous emphysema where current medical treatment fails, and as we continue to collect follow-up data, we hopefully will have a more complete profile of its applications in this patient population," he said.


'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. In Tests, Implanted Monitor Detects Atrial Fibrillation
2. New Implanted Defibrillator May Be Simpler, Safer
3. As End of Life Nears, What to Do With Implanted Defibrillators?
4. Implanted Heart Devices Have Real-World Benefits: Study
5. Penn study sheds light on end of life management of implanted defibrillators
6. Wireless power could cut cord for patients with implanted heart pumps
7. Combination therapy rids common infection from implanted medical devices
8. Cell Transplantation study shows bone growth from implanted tooth and dental pulp stem cells
9. Implanted Microchip Might Be Future of Drug Delivery
10. A New Website Series Improves Appearance and Health City by City
11. Behavioral therapy improves sleep and lives of patients with pain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... 2016 , ... The ThedaCare Center for Healthcare Value is ... April 5-7. The series is a multi-day, multi-workshop event designed to teach leaders ... broad range of topics, including coaching skills, the scientific method of problem solving ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Every winter, someone ... This winter the West Penn Burn Center, part of the Allegheny Health ... to bring you the “Space Heaters Need Space” campaign. , “Space ...
(Date:2/12/2016)... ... February 12, 2016 , ... AssureVest Insurance Group, a locally ... a charity drive that will raise funds earmarked to purchase computers and software for ... School. , “My school is in a low-income area and has more than 60 ...
(Date:2/12/2016)... ... February 12, 2016 , ... Vail knee specialist Robert LaPrade, MD, ... in 2016 . The list consists of physicians establishing, leading and partnering with ambulatory ... , An Ambulatory Surgery Center, also known as an ASC, is a modern ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... metro area, celebrates the beginning of the latest charity campaign in their community ... through art. Donations to this worthy cause are currently being accepted at: ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... , 12 februari 2016 AAIPharma ... toonaangevende leverancier van productie en ontwikkeling op ... kondigt vandaag een uitbreiding aan van steriele ... locatie in Charleston, SC ... tot meerdere recente investeringen. http://photos.prnewswire.com/prnh/20150806/256637LOGO ...
(Date:2/11/2016)... 2016 The primary goal of this research ... on the usage of liquid biopsy. Key information the ... - Timeframe of liquid biopsy adoption amidst future users ... organization type - Sample inflow to conduct liquid biopsy ... serum, and so on. - Correlation analysis of sample ...
(Date:2/11/2016)... OAKLAND, Calif. , Feb. 11, 2016  Walgreens ... stores across 39 states and Washington, D.C. ... in a move that was commended by shareholder advocacy organization ... President at As You Sow. "Many people hold on to ... options, which can have tragic consequences." --> ...
Breaking Medicine Technology: