Navigation Links
Tiny genetic variation can predict ovarian cancer outcome
Date:12/5/2011

Yale Cancer Center researchers have shown that a tiny genetic variation predicts chances of survival and response to treatment for patients with ovarian cancer.

The findings, published in the journal Oncogene, provide new insights into the biology of a new class of cancer marker and suggest a genetic test may help guide the treatment of women with ovarian cancer.

"This gives us a way to identify which women are at highest risk for resistance to platinum chemotherapy, the standard treatment for ovarian cancer, and helps identify ovarian cancer patients with the worst outcomes," said Joanne Weidhaas, associate professor of therapeutic radiology and senior author of the study. "There just aren't many inherited gene variants than can do that."

Women who possess the biomarker identified by the Yale team a variant of the well-known KRAS oncogene are three times more resistant to standard platinum chemotherapy than women without the variant. Also, post-menopausal women with the variant are significantly more likely to die from ovarian cancer. About 12-15 percent of Caucasians and 6 percent of African-Americans are born with the variant of the gene, which helps regulate destruction of damaged cells. This variant is found in up to 25% of newly diagnosed ovarian cancer patients.

Although good alternatives to chemotherapy are not yet available for women with ovarian cancer and this variant, several drugs in development which target the KRAS gene and associated pathways have shown great promise, Weidhaas said.

Weidhaas is a co-founder of a company that has licensed intellectual property from Yale that has developed a diagnostic test based on the Kras-variant.

The biomarker intrigues scientists because it is a functional variant in an area of DNA that does not code for proteins. Instead this variant disrupts how a microRNA controls gene expression.

"This is a new paradigm," Weidhaas said.

Yale
'/>"/>

Contact: Bill Hathaway
william.hathaway@yale.edu
203-432-1322
Yale University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Genetic sequencing could help match patients with biomarker-driven cancer trials, treatments
2. Unlocking the genetic and molecular mystery of soft-tissue sarcoma
3. CU-Boulder led study of smoking twins points to growing influence of genetic factors
4. Increasing dosage of clopidogrel for patients with genetic variation improves response to medication
5. Combination epigenetic therapy clinical trial results
6. Epigenetic therapy shows promise in hard-to-treat lung cancer
7. Breakthrough in understanding the genetics of high blood pressure
8. Possible Genetic Link to Autism Identified
9. Ohio State researchers design a viral vector to treat a genetic form of blindness
10. Study identifies genetic basis of human metabolic individuality
11. 23andMe discovers genetic variant that may protect those at risk for Parkinsons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... ... 2015 , ... Virginia entrepreneur Marcella Ellis, CEO and founder ... firm’s success in the hair care and distribution industry through her combination of ... be providing “Look and learn” live demonstrations, as well as promoting her new ...
(Date:9/1/2015)... ... September 01, 2015 , ... PetPace, the provider ... vital signs and activity, today announced its integration with leading veterinary Practice Management ... widely-adopted veterinary hospital Practice Management Software packages in the US. Practice Management Software ...
(Date:9/1/2015)... ... , ... Zecurion, a leading developer of data loss prevention solutions, announced the ... developed specifically for Mac OS. , In June 2015, the company successfully completed the ... professionals had participated. The beta test done by the developer community enabled Zecurion to ...
(Date:9/1/2015)... ... , ... SC&H Group, a leading audit, tax, and consulting firm, received multiple ... Best” firm in the U.S., as well as being ranked a Top 100 Accounting ... U.S., selected exclusively on performance in specific areas of financial and operational management. ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... 1,500 investor-families have received permanent green cards (I-829 petition approval) from the USCIS ... petition is the final step of the EB-5 visa process for immigrant investors ...
Breaking Medicine News(10 mins):Health News:Beauty Entrepreneur creates hair extension smart machine and mobile app inspired by UBER technology 2Health News:Petpace-Cornerstone Integration Lowers Overhead, Raises Data Visibility for Veterinary Practices 2Health News:Zecurion Announces Endpoint Security for Mac 2Health News:SC&H Group Receives Multiple Honors from INSIDE Public Accounting 2Health News:CanAm Enterprises Reaches Another Milestone with More Than 1,500 I-829 Petition Approvals 2
... LAUREL, N.J.,Nov. 20 MedQuist Inc. (Nasdaq: MEDQ ... and analytics applications for radiology, today announced a cooperative agreement ... speech recognition solution, SpeechQ for Radiology(TM). The companies will be ... (Nov. 30-Dec. 4 in Chicago): , , ...
... top priority for patients, clinicians , , THURSDAY, Nov. 20 ... treatment than root canals, according to a study by ... The findings suggest that every effort should be made ... The researchers examined the charts of a group of ...
... Annual LocumTenens.com Survey , ... Alpharetta, ... third-party-payer scrutiny of rising imaging costs, many radiologists fear the ... practices. More than half (52 percent) of radiologists responding to ...
... Innovation, makers of,PharmASSIST(R) pharmacy automation solutions, ... in Dallas, Texas has implemented the firm,s,PharmASSIST ... pharmacy sites.,Parkland Health & Hospital System has ... their core workflow platform. For those sites,filling ...
... As part of its mission to spur,research and ... The SCAN Foundation announced today it has awarded nearly,$1.4 ... health,professionals, policymakers, and the public about how to provide ... fund two (2) special,projects related to long-term care and ...
... Minn., Nov. 20 Forward Expeditions LLC, ... their upcoming historic Victorinox North,Pole expedition to ... nonprofit organization offering free personalized Web sites ... largest charitable,nonprofit Web site, CaringBridge connects more ...
Cached Medicine News:Health News:MedQuist and Primordial to Demonstrate Integrated Applications at RSNA 2Health News:MedQuist and Primordial to Demonstrate Integrated Applications at RSNA 3Health News:Dental Implants Need More Work Than Root Canals 2Health News:Radiologist Salary Survey Shows Fear of Universal Healthcare 2Health News:Radiologist Salary Survey Shows Fear of Universal Healthcare 3Health News:Parkland Health & Hospital System Rolls Out Innovation's PharmASSIST Technology Platform Across Nine Pharmacy Sites 2Health News:The SCAN Foundation Announces New Grants Aimed at Refocusing the Debate About Healthcare for Seniors 2Health News:Forward Expeditions to Promote CaringBridge(R) on Historic Victorinox North Pole '09 Expedition 2Health News:Forward Expeditions to Promote CaringBridge(R) on Historic Victorinox North Pole '09 Expedition 3Health News:Forward Expeditions to Promote CaringBridge(R) on Historic Victorinox North Pole '09 Expedition 4
(Date:9/1/2015)... , Sept. 1, 2015  Valeant Pharmaceuticals International, ... today announced that its affiliate has entered into ... was granted an exclusive license to develop and ... IL-17 receptor monoclonal antibody in development for patients ... the agreement, Valeant will hold the exclusive rights ...
(Date:8/31/2015)... , Aug. 31, 2015 Pepperl+Fuchs, a ... acquired MACTek Corporation, a leading provider of HART ... strategy to further extend its integrated solutions offerings ...   "We are pleased to add ... portfolio," said Jim Bolin , Pepperl+Fuchs, executive ...
(Date:8/31/2015)... , Aug. 31, 2015 Thousands of people ... neglect of the opioid addiction epidemic at dozens of ... term in 2008, the United States ... addiction involving prescription opioids and heroin, yet the President ... a strongly worded letter to President Obama , ...
Breaking Medicine Technology:Valeant And AstraZeneca To Partner On Brodalumab 2Valeant And AstraZeneca To Partner On Brodalumab 3Valeant And AstraZeneca To Partner On Brodalumab 4Obama Administration's Neglect of Opioid Crisis Prompts Rallies in Many States 2
... Sept. 7 Epeius Biotechnologies Corporation, a leader in ... publication of a landmark paper in clinical oncology. Following ... of Rexin-G in chemo-resistant metastatic pancreatic cancer ( Molecular ... Drug and FDA Fast Track Status, this new paper ...
... India, Sept. 7 Sun Pharmaceutical Industries Ltd. (Sun) ... today announced that the Supreme Court of Israel has ... (Taro) (Pink Sheets: TAROF ) of the ... the Israeli special tender offer (STO) rules do not ...
Cached Medicine Technology:To Reach, Perchance to Kill the Cancer: A Soliloquy From Epeius Nanotechnologies Opposes That 'Sea of Troubles' 2Supreme Court of Israel Rules in Favor of Sun Pharma 2Supreme Court of Israel Rules in Favor of Sun Pharma 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: