Navigation Links
Tiny genetic variation can predict ovarian cancer outcome
Date:12/5/2011

Yale Cancer Center researchers have shown that a tiny genetic variation predicts chances of survival and response to treatment for patients with ovarian cancer.

The findings, published in the journal Oncogene, provide new insights into the biology of a new class of cancer marker and suggest a genetic test may help guide the treatment of women with ovarian cancer.

"This gives us a way to identify which women are at highest risk for resistance to platinum chemotherapy, the standard treatment for ovarian cancer, and helps identify ovarian cancer patients with the worst outcomes," said Joanne Weidhaas, associate professor of therapeutic radiology and senior author of the study. "There just aren't many inherited gene variants than can do that."

Women who possess the biomarker identified by the Yale team a variant of the well-known KRAS oncogene are three times more resistant to standard platinum chemotherapy than women without the variant. Also, post-menopausal women with the variant are significantly more likely to die from ovarian cancer. About 12-15 percent of Caucasians and 6 percent of African-Americans are born with the variant of the gene, which helps regulate destruction of damaged cells. This variant is found in up to 25% of newly diagnosed ovarian cancer patients.

Although good alternatives to chemotherapy are not yet available for women with ovarian cancer and this variant, several drugs in development which target the KRAS gene and associated pathways have shown great promise, Weidhaas said.

Weidhaas is a co-founder of a company that has licensed intellectual property from Yale that has developed a diagnostic test based on the Kras-variant.

The biomarker intrigues scientists because it is a functional variant in an area of DNA that does not code for proteins. Instead this variant disrupts how a microRNA controls gene expression.

"This is a new paradigm," Weidhaas said.

Yale
'/>"/>

Contact: Bill Hathaway
william.hathaway@yale.edu
203-432-1322
Yale University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Genetic sequencing could help match patients with biomarker-driven cancer trials, treatments
2. Unlocking the genetic and molecular mystery of soft-tissue sarcoma
3. CU-Boulder led study of smoking twins points to growing influence of genetic factors
4. Increasing dosage of clopidogrel for patients with genetic variation improves response to medication
5. Combination epigenetic therapy clinical trial results
6. Epigenetic therapy shows promise in hard-to-treat lung cancer
7. Breakthrough in understanding the genetics of high blood pressure
8. Possible Genetic Link to Autism Identified
9. Ohio State researchers design a viral vector to treat a genetic form of blindness
10. Study identifies genetic basis of human metabolic individuality
11. 23andMe discovers genetic variant that may protect those at risk for Parkinsons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company ... to follow it on Facebook, Twitter, and Pinterest. The fans ... Angelweddingdress draws a lottery every week. , Moreover, the company ... 2015. Click Angelweddingdress homepage for more information. ...
(Date:1/22/2015)... York (PRWEB) January 22, 2015 The federal ... in the U.S. District Court, Southern District of West Virginia ... Inc. in that proceeding’s first bellwether trial. In an Order ... a new trial after finding that C.R. Bard had not ...
(Date:1/22/2015)... New York, New York (PRWEB) January 22, 2015 ... filed after Fresenius Medical Care recalled its GranuFlo ... the federal multidistrict litigation underway in U.S. District Court, ... an Order dated January 20th, the Court has remanded ...
(Date:1/22/2015)... 2015 Carinsurancesavings.biz has released a new blog ... dismemberment insurance . , Purchasing an accidental death and ... advantageous. This type of rider provides benefits if the insured ... considered a lesser form of life insurance. , AD&D ...
(Date:1/22/2015)... 22, 2015 Yesterday, Senator Holly ... and Kristin Olsen (R-Modesto) were honored by the ... advancing biotechnology, biomedical science, medical device and pharmaceutical ... received the “2014 Life Sciences Champion” award from ...
Breaking Medicine News(10 mins):Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3
... Understanding Not Confusion, FOLSOM, Calif., Feb. 20 ... California Walnut Commission: Given the state of the,national waistline, ... is clear. We welcome new independent nutrition rating systems,that ... While some fear,that this will be confusing, our research ...
... Health Solutions study finds anxiety over financial, preparedness; consumers ... ... presidential election, WASHINGTON, Feb. 20 American consumers want ... online,connection to health care providers and medical records, customized,insurance coverage and ...
... Latest procedures and techniques discussed at surgeons, conference, ... Achilles,tendon surgery patients are getting back on their ... The introduction of tissue graft products, bone anchors, ... with,less invasive treatments and speedier recovery times. More ...
... Feb. 20 Varian Medical,Systems (NYSE: VAR ... about,its revolutionary RapidArc(TM) radiotherapy technology for faster and ... opportunity,to learn more about a technology that makes ... two to eight,times faster than is possible with ...
... 012,Smile.Communications (Nasdaq: SMLC ) today announced ... Tuesday , February 26, 2008, before the,market is ... an interactive,teleconference to discuss the results at 09:00 ... following access numbers several minutes before the,call begins: ...
... The American Cancer Societys annual cancer statistics report finds that ... by 18.4 percent among men and by 10.5 percent among ... 1990s, which translates to the avoidance of more than half ... Society epidemiologists predict that in the U.S. in 2008 there ...
Cached Medicine News:Health News:Walnuts Rank High on New Nutrition Scales 2Health News:Walnuts Rank High on New Nutrition Scales 3Health News:Groundbreaking Deloitte Survey Reveals Many U.S. Consumers Want Major Changes in Health Care Design, Delivery 2Health News:Groundbreaking Deloitte Survey Reveals Many U.S. Consumers Want Major Changes in Health Care Design, Delivery 3Health News:Groundbreaking Deloitte Survey Reveals Many U.S. Consumers Want Major Changes in Health Care Design, Delivery 4Health News:Achilles Tendon Surgery Advances Speed Recovery 2Health News:Varian Medical Systems Announces Symposia on RapidArc Technology for Faster, More Precise Radiotherapy Treatments 2Health News:Varian Medical Systems Announces Symposia on RapidArc Technology for Faster, More Precise Radiotherapy Treatments 3Health News:012 Smile.Communication's Fourth Quarter Earnings Release and Conference Call Scheduled for February 26, 2008 2Health News:012 Smile.Communication's Fourth Quarter Earnings Release and Conference Call Scheduled for February 26, 2008 3Health News:Report says half a million cancer deaths have been averted since death rate drop 2Health News:Report says half a million cancer deaths have been averted since death rate drop 3Health News:Report says half a million cancer deaths have been averted since death rate drop 4Health News:Report says half a million cancer deaths have been averted since death rate drop 5
(Date:1/23/2015)... Inc. (ICBU) has repositioned itself as a holding company with ... in the hydroponic, hemp and medical marijuana sectors. By acquiring ... sector, and recently partnering with the Chippewa Tribe Nation to ... iMD is committing to bring its vision to the market ...
(Date:1/23/2015)... Jan. 23, 2015 Cord Blood America, Inc. ( www.cordblood-america.com ... the "Company")  filed a Preliminary Proxy Statement, Schedule 14A, with ... and provides an update for shareholders detailing why a "YES" ... Dear Shareholders, As we reflect upon ...
(Date:1/23/2015)... , Jan. 23, 2015  CytoSorbents Corporation (NASDAQ CM: ... CytoSorb® extracorporeal cytokine adsorber to reduce deadly inflammation ... receipt of $385,642, net of transaction costs, in ... Technology Business Tax Certificate Transfer Program sponsored by ...
Breaking Medicine Technology:iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 3Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 4CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3
The flexible EXXCEL ePTFE Vascular Access Graft material is designed to offer textile-like handling characteristics-cuts neatly for a clean edge, retains fully open lumen shape, and sutures smoothly....
... intended for monitoring the accuracy and precision of ... in vitro diagnostic use only. Provided in a ... up to ten days stability at 2 ... used in accordance with the directions accompanying the ...
PowerMed is a billing software....
Managed care is a billing and tracking system....
Medicine Products: