Navigation Links
Tiny antibody fragments raised in camels find drug targets in human breast cancer cells
Date:4/11/2011

A new discovery published online in The FASEB Journal (http://www.fasebj.org) promises to help physicians identify patients most likely to benefit from breast cancer drug therapies. If the compound, called "Nanobody," proves effective in clinical trials, it would represent a significant advance for breast cancer drug therapy because some drugs are effective only in some people. In addition, some drugs have side effects that may cause damage to vital organs, making it more crucial for physicians to get the right treatment to the right patient the first time around.

"What makes Nanobodies so promising is that they are robust, small enough for rapid elimination from the body, and easy to produce at a relatively low cost," said Ilse Vaneycken, M.Sc., a researcher involved in the work.

To make this discovery, Vaneycken and her colleagues started with the target of the therapeutic drugs (HER2) and immunized a dromedary camel to raise special antibodies unique to this species. Next, all unnecessary parts of the camel's antibodies were removed and cloned in bacteria. Of 100 million bacterial clones, the team selected those that produced the 40 Nanobodies that recognized― or bound to―the same site targeted by therapeutic drugs. Of this group, the team screened for compounds that picked out breast cancer cells bearing the genetic tag HER2. Their lead compound did just that, and without blocking access to cancer-killing drugs now in use. Other properties of Nanobodies, such as good expression, stability, and visibility―enabled breast cancer tumors to be stained and seen rapidly―were also exploited.

"The scientists went over the hump to get to the lump so to speak," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This technique not only promises to help doctors target cancer cells with effective drugs today, but to pick out other discrete cancer targets in the futur
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Fox Chase clinical trial tests first of its kind antibody
2. Antibody therapy lengthens survival of metastatic melanoma patients in large clinical trial
3. Antibody Linked to Allergies on the Rise
4. HJF signs distribution agreement for antibody to evaluate prostate cancer
5. Tufts receives patent for antibody treatment against hemolytic uremic syndrome
6. Migraine Tied to Raised Multiple Sclerosis Risk
7. Psoriasis Tied to Raised Heart Risk
8. Kids Raised by Relatives Face Increased Health Risks
9. Frequent Urination at Night Linked to Raised Death Risk
10. Belly-Baring Cheerleaders at Raised Risk of Eating Disorders
11. YAS-A-THON for ThinkCure Hits it Out of the Park: $140,000 Raised, 270,000 Calories Burned!
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Padre Murphy's and Owner Tom Boyle in Glendale, AZ has ... (PPHA). The PPHA's passion for others' well-being and shared ... treated for obstructive sleep apnea (OSA) has propelled them into ... the valley. The most recent plans for an event will ...
(Date:1/22/2015)... AngelWeddingDress, the premier women’s dress supplier, has recently released ... website of AngelWeddingDress.com to find more details. , ... for a bridal party. AngelWeddingDress offers a variety of ... maternity wedding dresses are specially designed for 2015. , ...
(Date:1/22/2015)... Autocarinsurancebest.com has released a new blog post ... insurance policy . , Auto insurance quotes help many ... no longer necessary to call an agent or visit an ... on a single website: http://autocarinsurancebest.com/ . , Every business ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Yesterday, ... Bonilla (D-Concord) and Kristin Olsen (R-Modesto) were honored ... leadership in advancing biotechnology, biomedical science, medical device ... Olsen each received the “2014 Life Sciences Champion” ...
(Date:1/22/2015)... EBSCO Information Services (EBSCO) and the ... in an effort to further promote visibility and adoption of ... long made AMA journals available via its subscription services, EBSCO ... Network. , Long known as both a subscription ...
Breaking Medicine News(10 mins):Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4
... study at different dosages , , THURSDAY, April 23 (HealthDay ... grape seed extract lowers hormone levels in postmenopausal women ... the City of Hope cancer center in Duarte, Calif. ... inhibits aromatase, an enzyme that helps in estrogen production, ...
... other ,high-glycemic, carbs, researchers say , , THURSDAY, April 23 (HealthDay ... a workout may influence how many calories you burn during ... breakfast rich in carbohydrates that do not cause a spike ... -- burned 50 percent more fat during a post-breakfast workout ...
... LOUIS, April 23 Sigma-Aldrich Corporation, a leading Life Science ... diluted EPS grew by 6% to $0.68 from $0.64 in ... of 2009 were $519 million, a decline of 9% from ... first quarter sales grew organically by 1% from a year ...
... with grave concerns about the care of their patients at ... directly to Heather Howard, New Jersey Commissioner of Health and ... at about 11:30 a.m.Some 80 Registered and Practical nurses, members ... Health Care Employees, have been without a contract for a ...
... LAIYANG, China, April 23 /PRNewswire-Asia-FirstCall/ -- Genesis,Pharmaceuticals Enterprises, ... pharmaceutical company with its principal operations in the ... changed its name to "Jiangbo,Pharmaceuticals, Inc." ("Jiangbo"). , ... from the Department of State of the,State of ...
... a pioneer in assisting clients achieve next generation clinical and ... announced that CEO, Dr. Randall Williams, will partner with four ... Telemedicine Association,s 2009 conference in Las Vegas., ... April 27, 2009 @ 9:15 a.m. with Dr. Thomas ...
Cached Medicine News:Health News:No Verdict Yet on Grape Seed Extract vs. Breast Cancer 2Health News:A Pre-Workout Meal to Help You Burn Fat 2Health News:A Pre-Workout Meal to Help You Burn Fat 3Health News:Sigma-Aldrich (Nasdaq: SIAL) Reports 6% Increase In First Quarter 2009 Diluted EPS to $0.68. All Research Units Achieve Organic Sales Growth. Full Year 2009 Guidance Reaffirmed; Diluted EPS Expected to Exceed Reported EPS for 2008 of $2.65. 2Health News:Sigma-Aldrich (Nasdaq: SIAL) Reports 6% Increase In First Quarter 2009 Diluted EPS to $0.68. All Research Units Achieve Organic Sales Growth. Full Year 2009 Guidance Reaffirmed; Diluted EPS Expected to Exceed Reported EPS for 2008 of $2.65. 3Health News:Sigma-Aldrich (Nasdaq: SIAL) Reports 6% Increase In First Quarter 2009 Diluted EPS to $0.68. All Research Units Achieve Organic Sales Growth. Full Year 2009 Guidance Reaffirmed; Diluted EPS Expected to Exceed Reported EPS for 2008 of $2.65. 4Health News:Sigma-Aldrich (Nasdaq: SIAL) Reports 6% Increase In First Quarter 2009 Diluted EPS to $0.68. All Research Units Achieve Organic Sales Growth. Full Year 2009 Guidance Reaffirmed; Diluted EPS Expected to Exceed Reported EPS for 2008 of $2.65. 5Health News:Sigma-Aldrich (Nasdaq: SIAL) Reports 6% Increase In First Quarter 2009 Diluted EPS to $0.68. All Research Units Achieve Organic Sales Growth. Full Year 2009 Guidance Reaffirmed; Diluted EPS Expected to Exceed Reported EPS for 2008 of $2.65. 6Health News:Sigma-Aldrich (Nasdaq: SIAL) Reports 6% Increase In First Quarter 2009 Diluted EPS to $0.68. All Research Units Achieve Organic Sales Growth. Full Year 2009 Guidance Reaffirmed; Diluted EPS Expected to Exceed Reported EPS for 2008 of $2.65. 7Health News:Sigma-Aldrich (Nasdaq: SIAL) Reports 6% Increase In First Quarter 2009 Diluted EPS to $0.68. All Research Units Achieve Organic Sales Growth. Full Year 2009 Guidance Reaffirmed; Diluted EPS Expected to Exceed Reported EPS for 2008 of $2.65. 8Health News:Sigma-Aldrich (Nasdaq: SIAL) Reports 6% Increase In First Quarter 2009 Diluted EPS to $0.68. All Research Units Achieve Organic Sales Growth. Full Year 2009 Guidance Reaffirmed; Diluted EPS Expected to Exceed Reported EPS for 2008 of $2.65. 9Health News:Sigma-Aldrich (Nasdaq: SIAL) Reports 6% Increase In First Quarter 2009 Diluted EPS to $0.68. All Research Units Achieve Organic Sales Growth. Full Year 2009 Guidance Reaffirmed; Diluted EPS Expected to Exceed Reported EPS for 2008 of $2.65. 10Health News:Sigma-Aldrich (Nasdaq: SIAL) Reports 6% Increase In First Quarter 2009 Diluted EPS to $0.68. All Research Units Achieve Organic Sales Growth. Full Year 2009 Guidance Reaffirmed; Diluted EPS Expected to Exceed Reported EPS for 2008 of $2.65. 11Health News:Sigma-Aldrich (Nasdaq: SIAL) Reports 6% Increase In First Quarter 2009 Diluted EPS to $0.68. All Research Units Achieve Organic Sales Growth. Full Year 2009 Guidance Reaffirmed; Diluted EPS Expected to Exceed Reported EPS for 2008 of $2.65. 12Health News:Sigma-Aldrich (Nasdaq: SIAL) Reports 6% Increase In First Quarter 2009 Diluted EPS to $0.68. All Research Units Achieve Organic Sales Growth. Full Year 2009 Guidance Reaffirmed; Diluted EPS Expected to Exceed Reported EPS for 2008 of $2.65. 13Health News:Sigma-Aldrich (Nasdaq: SIAL) Reports 6% Increase In First Quarter 2009 Diluted EPS to $0.68. All Research Units Achieve Organic Sales Growth. Full Year 2009 Guidance Reaffirmed; Diluted EPS Expected to Exceed Reported EPS for 2008 of $2.65. 14Health News:Sigma-Aldrich (Nasdaq: SIAL) Reports 6% Increase In First Quarter 2009 Diluted EPS to $0.68. All Research Units Achieve Organic Sales Growth. Full Year 2009 Guidance Reaffirmed; Diluted EPS Expected to Exceed Reported EPS for 2008 of $2.65. 15Health News:Genesis Pharmaceuticals Changes its Name to Jiangbo Pharmaceuticals, Inc. to Reflect its Brand Name 2Health News:Genesis Pharmaceuticals Changes its Name to Jiangbo Pharmaceuticals, Inc. to Reflect its Brand Name 3Health News:Pharos Innovations and Clients to Showcase Three Client Case Studies at Upcoming ATA Conference 2
(Date:1/22/2015)... 2015  Uroplasty, Inc. (NASDAQ: UPI ), a medical ... products to treat voiding dysfunctions, today reported financial results ... Global revenue for the Company,s Urgent ® ... new quarterly revenue record, as compared to $3.9 million ...
(Date:1/22/2015)... 22, 2015  Amgen (NASDAQ: AMGN ) today announced that ... results on Tuesday, Jan. 27, 2015, after the close of the ... call with the investment community at 2 p.m. PT. Participating in ... chairman and chief executive officer, and other members of Amgen,s senior ...
(Date:1/22/2015)... PARK, Calif. , Jan. 22, 2015 Increasing ... the continued consolidation of localization purchasing in 2015, says ... According to a recent study by market research ... chose a single-source solution for their translation and localization ...
Breaking Medicine Technology:Uroplasty Reports Record Revenue in Fiscal Third Quarter 2Uroplasty Reports Record Revenue in Fiscal Third Quarter 3Uroplasty Reports Record Revenue in Fiscal Third Quarter 4Uroplasty Reports Record Revenue in Fiscal Third Quarter 5Uroplasty Reports Record Revenue in Fiscal Third Quarter 6Uroplasty Reports Record Revenue in Fiscal Third Quarter 7Uroplasty Reports Record Revenue in Fiscal Third Quarter 8Uroplasty Reports Record Revenue in Fiscal Third Quarter 9Uroplasty Reports Record Revenue in Fiscal Third Quarter 10Uroplasty Reports Record Revenue in Fiscal Third Quarter 11Uroplasty Reports Record Revenue in Fiscal Third Quarter 12Uroplasty Reports Record Revenue in Fiscal Third Quarter 13Uroplasty Reports Record Revenue in Fiscal Third Quarter 14Uroplasty Reports Record Revenue in Fiscal Third Quarter 15Uroplasty Reports Record Revenue in Fiscal Third Quarter 16Uroplasty Reports Record Revenue in Fiscal Third Quarter 17Uroplasty Reports Record Revenue in Fiscal Third Quarter 18Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2
... , WOODLAND HILLS, Calif., Oct. 28 Infor-Med Corporation, ... the beta release of Praxis Version 5 featuring Datum, ... to create, store, and share discrete clinical data. The ... funds and is designed to meet future ,meaningful use, ...
... Calif., Oct. 28 Cell Biosciences, Inc. today announced ... Corp. (OTC Bulletin Board: APNO). The stockholders of Alpha ... other conditions have been satisfied. Pursuant to the merger ... stockholders will receive $1.50 per share, or approximately $17.9 ...
Cached Medicine Technology:Praxis Electronic Medical Records Announces New Version 5 With Breakthrough in EHR Documentation 2
... PLIF instrument set consists of modular ... nerve root protectors, for bone graft ... bone blocks of the Lumbar I/F ... preparation which is important for graft ...
... consists of modular shavers and spreaders that ... space, and prepare the endplates for graft. ... for effective interbody fusion the disc and ... Gradual distraction of the disc space by ...
... The Access Dilation Port enables the ... a minimally invasive approach using step dilation. ... is gently pushed aside, creating space for ... port allows the surgeon to operate with ...
... screw insertion assembly incorporates slotted guides ... locking. The PathFinder MIS System uses ... pedicle screw insertion assembly incorporates crescent-shaped ... The evolutionary Pathfinder MIS pedicle screw ...
Medicine Products: