Navigation Links
Tiny RNA molecule may have role in polycystic ovary syndrome, insulin resistance
Date:3/19/2013

AUGUSTA, Ga. A group of tiny RNA molecules with a big role in regulating gene expression also appear to have a role in causing insulin resistance in woman with polycystic ovary syndrome and, perhaps, in all women, researchers report.

Research in the journal Diabetes, indicates that high activity levels of a microRNA called miR-93 in fat cells impedes insulin's use of glucose, contributing to PCOS as well as insulin resistance, said Dr. Ricardo Azziz, reproductive endocrinologist and PCOS expert at the Medical College of Georgia at Georgia Regents University.

"This is one of the first reports of a defect that may occur both in women who are insulin resistant and, in particular, in women with PCOS," said Azziz, the study's corresponding author. "Identifying this molecular mechanism helps us understand these common conditions better and points us toward targeted therapies to correct these problems in women."

PCOS affects about 10 percent of women and is characterized by excess male hormone, irregular ovulation and menstruation and is associated with an increased risk for insulin resistance, which can lead to diabetes and heart disease.

Researchers looked at fat cells from the lower abdomen of 21 women with PCOS and 20 controls. In all the women with PCOS, they found over expression of miR-93 and decreased expression of GLUT4, a key protein that regulates fat's use of glucose for energy. Fat, a large organ in even a thin individual, is where a lot of glucose usage via insulin occurs.

GLUT4 expression was lowest in the women with PCOS who also were insulin resistant. They also found the expression was low in members of the control group who were insulin resistant.

"Low levels of GLUT4 in fat appear to be affecting insulin resistance in general and to have a more dramatic impact in PCOS," Azziz said. MiR-93 was known to impact GLUT4 in other cell types and to have a role in reproduction, infertili
'/>"/>

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Molecule movements that make us think
2. Prions in the brain eliminated by homing molecules
3. Researchers identify a life-and-death molecule on chronic leukemia cells
4. Inhibitors of shuttle molecule show promise in acute leukemia
5. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
6. Cleveland Clinic researchers discover molecule that may prevent atherosclerosis
7. Molecule found that inhibits recovery from stroke
8. Molecule shows effectiveness against drug-resistant myeloma
9. Measuring molecules with the naked eye
10. New developments reveal a molecule with a promising function in terms of cancer treatment.
11. Fat molecule ceramide may factor in muscle loss in older adults
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tiny RNA molecule may have role in polycystic ovary syndrome, insulin resistance
(Date:8/27/2014)... All Canada Goose Parkas from CanadaGooseJackor.nu are great. ... modern. With unique detailing such as buttons, leather trim and ... up in opulence. Recently, the company has unveiled its new ... , True enough, the new assortment comes in various ... 28% off) on all these brand new items. By launching ...
(Date:8/27/2014)... 28, 2014 Top 10 Best SEO Hosting, ... Linux hosting suppliers and announced iPage, Bluehost and GoDaddy are ... Canada, Australia and Europe to buy useful hosting (including VPS ... reliable suppliers, iPage has been serving hosting small ... it has grown into a leader in the hosting industry ...
(Date:8/27/2014)... New Jersey’s own Morgan Hoffmann turned in a ... The Barclays – and thanks to finishing high on ... rounds, stepped his way into raising another $7,500 for ... New Jersey (Horizon BCBNSNJ) Walking Challenge. , Last Tuesday, ... family and friends at the Paramus course, to wear ...
(Date:8/27/2014)... uses topical agents and light to kill tissue) appears ... lesion caused by sun damage) at three months after ... lesions). , Author: Gayatri Patel, M.D., M.P.H., ... Sacramento, and colleagues. , Background: AKs are ... individuals with fair complexions who have had lots of ...
(Date:8/27/2014)... 2014 Sound Telecom, a leading telecommunications ... cloud-based business communication systems, has unveiled an article titled ... Secure Text Messaging .” The piece examines the world ... do to remain compliant with HIPAA and HITECH requirements. ... and C.O.O. at Sound Telecom, opens with evidence that ...
Breaking Medicine News(10 mins):Health News:CanadaGooseJackor.nu: 2014 Canada Goose Banff Parkas At Discounted Prices 2Health News:Well-known SEO Hosts Review Site Top10BestSEOHosting.com Recommends iPage, Bluehost and GoDaddy To Webmasters 2Health News:Morgan Hoffmann, PGA TOUR Pro & Wyckoff Native, golfs and walks his way to top 10 finish at The Barclays while raising additional $7,500 for charity 2Health News:Photodynamic therapy vs. cryotherapy for actinic keratoses 2Health News:Sound Telecom Releases Article on Secure Messaging with Huge Implications for the Healthcare Industry 2Health News:Sound Telecom Releases Article on Secure Messaging with Huge Implications for the Healthcare Industry 3
... on evaluating eHealth in the open access journal ... The University of Edinburgh, Edinburgh, Scotland outline the background ... the widespread investments in and adoption of information communication ... supported by a grant from the NHS Connecting for ...
... preliminary evaluation of methylation of two gene promoters in ... detect colorectal and gastric cancers, according to a new ... of the National Cancer Institute . Because ... the detection of gastrointestinal cancers, the development of nonintrusive ...
... levels of vitamin D are known to nearly double the ... at Washington University School of Medicine in St. Louis now ... deficient in vitamin D can,t process cholesterol normally, so it ... heart attack and stroke. The new research has identified a ...
... Pa., Aug. 21 InfoLogix, Inc. ("InfoLogix" or the "Company") ... enterprise mobility solutions for the healthcare and commercial industries, today ... the U.S. Securities and Exchange Commission ("SEC") in connection with ... proposed recapitalization plan of the Company and certain related matters. ...
... LITTLE FALLS, N.J., Aug. 21 CANTEL MEDICAL CORP. ... it received a letter of resignation from Ms. Elizabeth McCaughey as a ... director since 2005, stated that she was resigning to avoid any appearance ... , , About Cantel Medical Corp. ...
... jolt tied to chronic head pain, study finds , FRIDAY, ... headaches, may cause them if consumed in large quantities. , ... people who were questioned about caffeine intake and headache ... 2) in Norway. , The study was published recently in ...
Cached Medicine News:Health News:eHealth interventions need to be continuously evaluated 2Health News:Fecal DNA methylation detects gastric and colorectal cancers 2Health News:Research shows why low vitamin D raises heart disease risks in diabetics 2Health News:InfoLogix Files Preliminary Proxy Statement in Connection with Special Meeting of Its Stockholders to Approve Recapitalization Plan 2Health News:InfoLogix Files Preliminary Proxy Statement in Connection with Special Meeting of Its Stockholders to Approve Recapitalization Plan 3Health News:InfoLogix Files Preliminary Proxy Statement in Connection with Special Meeting of Its Stockholders to Approve Recapitalization Plan 4Health News:High-Octane Caffeine May Trigger Headaches 2
(Date:8/27/2014)... Aug. 27, 2014 Reportlinker.com announces that ... its catalogue: Global Orthopedic Soft Tissue ... http://www.reportlinker.com/p02316671/Global-Orthopedic-Soft-Tissue-Repair-Devices-Market-2014-2018.html About Orthopedic Soft ... mass of cells that connect, support, or surround ... tissues such as tendons, ligaments, cartilage, fascia, and ...
(Date:8/27/2014)... Aug. 27, 2014  Decision Resources Group finds ... oncology, hematology-oncology, rheumatology, gastroenterology, endocrinology and nephrology) expect ... a biosimilar has been assessed in to be ... choose to prescribe. Other key ... Acceptance of Biosimilars Across Physician Specialties ...
(Date:8/27/2014)... , Aug. 27, 2014 Decision Resources Group ... the Memphis health system and ... clinical integration, with rivals Methodist Le Bonheur Healthcare and ... groups to coordinate patient care. In addition, a national ... the most health plan enrollment in the ...
Breaking Medicine Technology:Global Orthopedic Soft Tissue Repair Devices Market 2014-2018 2Global Orthopedic Soft Tissue Repair Devices Market 2014-2018 3Global Orthopedic Soft Tissue Repair Devices Market 2014-2018 4Global Orthopedic Soft Tissue Repair Devices Market 2014-2018 5Surveyed Physicians Expect to Choose Between Future Biosimilars Based on Robustness and Number of Clinical Trials 2Memphis-area Health Systems Turn Attention to Clinical Integration 2
... Must for Clinical Trials Management, WASHINGTON, ... Centers (AAHC) today launched a new Clinical ... center leaders,research administrators, and chief compliance officers ... for the,research enterprise, particularly to manage and ...
... and limited launch in Italy continue, FRANKLIN, Mass., ... announced today that it will defer the commencement of ... prevention of,Contrast-Induced Nephropathy (CIN). The company continues to support ... well,as the limited market launch of RenalGuard in Europe, ...
Cached Medicine Technology:New AAHC Toolkit Available to Optimize Clinical Research Administration 2PLC Systems Defers Pivotal Study of RenalGuard(TM) in the U.S. 2PLC Systems Defers Pivotal Study of RenalGuard(TM) in the U.S. 3PLC Systems Defers Pivotal Study of RenalGuard(TM) in the U.S. 4PLC Systems Defers Pivotal Study of RenalGuard(TM) in the U.S. 5
... Designs ROM post-operative knee braces are designed ... rehabilitation. , ,Adjustable and versatile, ROM ... for health care professionals. The braces are ... feature quick dial combination hinges that allow ...
... Neuroprene™ soft supports are a convenient, ... proprioceptive taping for common orthopedic conditions/instabilities. ... provide specific compression and lateral to ... (proprioceptors) in the skin and soft ...
... The Deluxe Heavy Duty Drop Lock Post Operative ... pin hinge with a spring loaded drop lock ... arms and contoured plates prevent the brace from ... a tibial offset for anatomical alignment that controls ...
... might just be the world's most versatile ... support, post-op/rehab support, or both, Flex is ... Accutrac™ ROM hinges control flexion and extension ... durability while being heat-moldable to accommodate changes ...
Medicine Products: