Navigation Links
Tiny Fish Might Help Humans Fix Damaged Hearts
Date:3/24/2010

When zebrafish loses cardiac tissue, it simply regrows it, scientists say

WEDNESDAY, March 24 (HealthDay News) -- An ability to regrow damaged or missing heart tissue makes the lowly zebrafish an ideal model for discovering new ways to repair human hearts, scientists say.

When a part of its heart is removed, the tiny zebrafish is a bit sluggish for a few days, but then appears normal within a month. This remarkable heart repair is achieved by differentiated cardiac muscle cells called cardiomyocytes -- not stem cells, but mature cells that normally supply the contractile force of the heart.

"What the results of our study show is that Mother Nature utilizes other ways besides going all the way back to pluripotent stem cells to regenerate tissues and organs," Juan Carlos Izpisua Belmonte, a professor in the Gene Expression Laboratory at the Salk Institute for Biological Studies in California, said in a news release.

The study appears in the March 25 issue of the journal Nature.

Prior to heart failure, damaged mammal heart muscle cells enter a state called hibernation, in which they stop contracting in an effort to survive. Mammal heart cell hibernation is significant, said study first author Chris Jopling, a postdoctoral fellow at the Center of Regenerative Medicine in Barcelona, Spain.

"During heart regeneration in the zebrafish we found that cardiomyocytes displayed structural changes similar to those observed in hibernating cardiomyocytes," Jopling said in the news release. "Because of these similarities, we hypothesize that hibernating mammalian cardiomyocytes may represent cells that are attempting to proliferate."

"This idea fits nicely with the findings from a number of groups -- that forced expression of cell cycle regulators can induce cardiomyocyte proliferation in mammals. Maybe all they need is a bit of push in the right direction," Jopling said.

Researchers are looking for factors that supply that push.

More information

The American Heart Association has more about heart attack.



-- Robert Preidt



SOURCE: Salk Institute for Biological Studies, news release, March 24, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Secret to healing chronic wounds might lie in tiny pieces of silent RNA
2. Stem Cells Might One Day Treat Severe Asthma
3. High-Impact Sports Might Not Harm Knee Replacements
4. Light Drinking Might Help Keep Women Slim
5. Alcohol Influences How Memorable Trauma Might Be
6. Scans Might Monitor Success of Alzheimers Drugs
7. Meat Might Be Behind Many Unidentified Allergic Reactions
8. Penicillin Allergy Might Not Include Related Antibiotic
9. Blood Test Might Sort Out Milk Allergies
10. Kids Peanut Allergies Might Be Tamed: Study
11. Increasing neurogenesis might prevent drug addiction and relapse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2017)... ... April 26, 2017 , ... ... an agile ecosystem and domain expertise for sponsors and CROs to speed ... trial supply management (RTSM) software platform. Bioclinica AGILE RTSM provides ...
(Date:4/25/2017)... (PRWEB) , ... April 25, ... ... based in Newport Beach, California, committed to raising awareness for Duchenne muscular ... results from its randomized CAP-1002 (cardiosphere-derived cells) Phase I/II HOPE clinical trial ...
(Date:4/25/2017)... ... , ... Lake Park Dental is now accepting new patients with crooked teeth ... With the help of this highly-effective, yet convenient system, patients can straighten their teeth ... less pain. , Drs. Sarah Jockin, Nicole Morganti, Sara Spear and Elizabeth Dy, ...
(Date:4/25/2017)... (PRWEB) , ... April 25, 2017 , ... Buyers and ... recreational users to dispensaries and head shops –can’t help but be heartened by the ... the tell-tale cannabis odor aptly described as “skunk smell.” At last they can ...
(Date:4/25/2017)... ... April 25, 2017 , ... ... healthcare products, is introducing Flexadin UCII, part of the EQUISTRO line, at this ... joint health in horses at the immunologic level. , The scientifically-developed Flexadin UCII ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , April 19, 2017 ... stimulate an immune response in pets such as ... products are of various types such as Attenuated ... Toxoid Vaccines, DNA Vaccines and Recombinant Vaccines. Attenuated ... as virus or bacteria, which have been weakend ...
(Date:4/19/2017)... N.J. , April 19, 2017  Novartis ... by the National Heart, Lung, and Blood Institute ... demonstrating that 58% of patients with treatment-naïve severe ... months when treated with eltrombopag at the initiation ... . The study evaluated three sequential treatment groups, ...
(Date:4/18/2017)... April 18, 2017  Cardinal Health (NYSE: ... fiscal 2017 earnings per share (EPS) guidance and providing ... is in conjunction with this morning,s announcement of the ... and Nutritional Insufficiency businesses. Cardinal Health now ... will be at the bottom of its previous guidance ...
Breaking Medicine Technology: