Navigation Links
Timing of Oxygen After a Stroke May Matter

Treatment while blood flow is blocked protects tissue, animal study finds,,

MONDAY, Oct. 19 (HealthDay News) -- Contradicting previous research, scientists have shown in animal studies that providing supplemental oxygen during an ischemic stroke can reduce brain damage.

But it's not a simple matter. Success in preventing brain damage, their new study says, depends on when 100 percent oxygen is given.

"The use of supplemental oxygen after blood flow is restored in the brain appears to actually cause harm by unleashing free radicals," Savita Khanna, an assistant professor of surgery at Ohio State University and principal investigator of the new study, said in a university news release. "The resulting tissue damage was worse than stroke-affected tissue that received no treatment at all."

The findings were scheduled to be presented Oct. 19 at the Society for Neuroscience annual meeting in Chicago.

According to the study authors, earlier research in people suggested that administration of oxygen actually could hurt those who'd had a stroke. But Khanna said it's crucial to consider the status of blood flow through the brain when someone is given oxygen.

The researchers looked at ischemic strokes, in which a blockage stops blood flow in the brain. In the other type of stroke, called hemorrhagic stroke, a blood vessel in the brain ruptures.

In the study, oxygen was given to five groups of rats that had induced strokes. Four groups were given normal oxygen or pressurized oxygen; some got it while blood flow was restricted, and others received it when blood flow was restored. One group of mice just breathed room air.

The researchers scanned the brains of the rats after two days to determine how much brain tissue was damaged. They found brain damage in the rats that were given supplemental oxygen while blood flow was blocked.

"Ultimately, the supplemental oxygen after blood flow is restored is more than the tissue can handle and is more than it needs," Cameron Rink, an assistant professor of surgery at Ohio State and a study co-investigator, said in the news release. "Why add oxygen on top of tissue that's already oxygenated? Supplemental oxygen during the blockage, on the other hand, is highly protective."

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about stroke.

-- Randy Dotinga

SOURCE: Ohio State University, news release, Oct. 19, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Beauty and the Economy: Unusual Timing for Dallas Uptown Medi-Spa Launch
2. Timing, Type of HRT May Determine Breast Cancer Risk
3. PLC Systems Reports Second Quarter 2009 Results; Announces Timing for Release of Preliminary Data From Italian Study of RenalGuard
4. China Medical Technologies Announces the Substantial Completion of an Independent Internal Investigation and Expected Timing of Reporting of Unaudited Financial Results for the Quarter and Fiscal Year ended March 31, 2009 and the Quarter ended June 30, 20
5. Gene May Help Predict Timing of Alzheimers Onset
6. Transdel Pharmaceuticals Provides Update on Timing of Results for Phase 3 Study
7. Ethnicity affects timing and access to cardiac care
8. Timing May Matter in Organ Donation Decisions
9. Forest Laboratories, Inc. and Cypress Bioscience, Inc. Announce Revised Timing for Commercial Availability of Savella(TM)
10. Study Finds Timing Is Everything For Some Heart Attack Patients
11. A new breakthrough in timing of urgent endoscopy for gastrointestinal bleeding patients
Post Your Comments:
(Date:6/26/2016)... North Carolina (PRWEB) , ... June 26, 2016 , ... ... release of a new product that was developed to enhance the health of felines. ... for centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library ... City Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ... for fumigation is not a common occurrence, but a necessary one in the event that ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of ... recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at Work ... Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
(Date:6/24/2016)... ... ... of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum Wage’ ... 2020 and then adjusting it yearly to increase at the same rate as the median ... floor does not erode again, and make future increases more predictable. , The company is ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Ontario , June 27, 2016  VMS Rehab ... Company,s Board will take whatever measures required to build ... Company,s stock which is currently listed on the OTC ... Wexler, Company Chairman and CEO, "We are seeing an ... difficult to understand, not only by the Company, but ...
(Date:6/24/2016)... 24, 2016  Global Blood Therapeutics, Inc. (GBT) (NASDAQ: ... novel therapeutics for the treatment of grievous blood-based ... closing of its previously announced underwritten public offering ... public offering price of $18.75 per share. All ... by GBT. GBT estimates net proceeds from the ...
(Date:6/24/2016)... 24, 2016 The Academy of Managed Care ... that would allow biopharmaceutical companies to more easily ... make formulary and coverage decisions, a move that addresses ... medicines. The recommendations address restrictions in the ... the drug label, a prohibition that hinders decision makers ...
Breaking Medicine Technology: