Navigation Links
Tighter tummies: A new way to combat weight gain
Date:3/3/2008

Two cell proteins that relax the gut and help accommodate a big meal have been identified by UCL (University College London) scientists. The proteins could offer a future drug target against weight gain, by preventing the stomach from expanding.

In a paper published in this months issue of the Journal of Pharmacology and Experimental Therapeutics, Dr Brian King and Dr Andrea Townsend-Nicholson explored the molecular basis of relaxations of the gut. In the study, the authors identified two protein receptors P2Y1 and P2Y11 involved in fast and slow relaxations of the gut. These proteins were identified in the guinea pig, but are also present in the human gut, and thus offer the potential as a future target for drug treatment. Further research by the UCL team will focus on the human isoform of the P2Y11 protein receptor.

Dr Brian King of the UCL Department of Neuroscience, Physiology and Pharmacology says: The mechanisms we have identified are important to the normal workings of the stomach - a hollow organ which actively relaxes to help accommodate the size of your meal. The human stomach has a resting internal volume of 75 millilitres but, by relaxing its muscular wall, can expand to an internal volume of two litres or more - a 25-fold increase in the volume it can accept. This expansion is controlled by nerves inside the stomach wall and these nerves release molecules that stimulate the P2Y1 and P2Y11 receptor proteins embedded in muscle cells in the gut wall.

The mechanism of slow relaxation of the stomach might represent a future drug target in the fight to control weight gain and reverse obesity. We are looking to identify drugs that would block the P2Y11 receptor and, therefore, prevent slow relaxation of the stomach. As a result of blocking the P2Y11-based mechanism, meal size would be smaller, offering the person a better chance of regulating their food intake.

This would be a brand new approach to weight control.
'/>"/>

Contact: Jenny Gimpel
j.gimpel@ucl.ac.uk
University College London
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Anthem Blue Cross and Blue Shield Teams with the State of Indiana to Combat Obesity
2. Five Years of VA Health Care for Combat Veterans
3. Nations to Launch Negotiations on Treaty to Combat Illicit Tobacco Trade
4. U.S. on Sidelines as Nations Launch Negotiations on Treaty to Combat Smuggling, Counterfeiting and Other Illicit Trade in Tobacco Products
5. Grapefruit compound may help combat hepatitis C infection
6. ONDCP Launches First Major Initiative to Combat Teen Prescription Drug Abuse
7. Consuming extra virgin olive oil helps to combat degenerative diseases such as cancer
8. Indian medicinal plant Acanthus ilicifolius may combat liver cancer
9. World Vision Index of Concern: Half of Americans Surveyed Said They Would Be Willing to Pay More Taxes to Combat AIDS
10. Global Health Support Service Benchmark Study to Combat Growing Healthcare Costs and Prepare for Likely Health Care Reforms
11. New Academic Analysis Identifies Three Barriers to Achieving Healthy and Achievable Policies to Combat Obesity in America
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... Clara, CA (PRWEB) July 29, 2014 ... Valley Boomer Venture Summit concluded with the $10,000 prize ... of Bikanta. ( http://www.bikanta.com ) , The 11th Annual ... pairs investors with entrepreneurs who can bring innovative products ... , “We are pleased to have had such excellent ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 "Acceptance, Recognition, ... man who faced his own demons and wants other men ... intended life partner left. A month later, he had no ... longer pay. When Raymond approached the government for assistance, the ... a two-year counselling program. But this approach didn’t get to ...
(Date:7/29/2014)... WI (PRWEB) July 29, 2014 The ... development project, The Cottages at MeadowLands Memory Care, to ... population of those suffering from memory loss and forms ... Inc., has approved the development of Oconto Fall’s first ... Cara Peterson, GM of The Cottages Investment Group, LLC ...
(Date:7/29/2014)... 29, 2014 Tucson-based company Outski ... benefits package, or health and wellness program, called 401(play)™. ... providing an effective way for employees to use their ... the program, employees specify the amount of each paycheck ... An employer benefits from offering a 401(play)™ plan to ...
(Date:7/29/2014)... In his latest blog post at http://www.perwickstrom.com , ... has listed 6 ways to light the “fire” in employees. ... complacency, but for some it’s a losing battle,” commented ... ways to help employees get to the next level; which ... , According to Per Wickstrom, 6 ways to light the ...
Breaking Medicine News(10 mins):Health News:Silicon Valley Boomer Venture Summit Names Bikanta Competition Winner 2Health News:SBPRA Announces the Release of Its Newest Title, "Acceptance, Recognition, and Control (A.R.C.) Against Depression" 2Health News:The Cottages Investment Group Announces Third Development Project, The Cottages at MeadowLands Memory Care, Oconto Falls 2Health News:The Cottages Investment Group Announces Third Development Project, The Cottages at MeadowLands Memory Care, Oconto Falls 3Health News:The Cottages Investment Group Announces Third Development Project, The Cottages at MeadowLands Memory Care, Oconto Falls 4Health News:Outski launches 401(play)™ Plan to Employers as Part of an Employee Benefit / Health and Wellness Program 2Health News:Per Wickstrom’s Latest Blog Post Lists 6 Ways to Light the “Fire” in Employees 2
... NEW YORK, Dec. 8 Parenting a family of any size ... difference is that in this "second family," the parenting does not ... parents. , According to William Bryan, Ph.D., cofounder of Active ... to define this particular phenomenon that affects 10 million households where ...
... , LONDON, Dec. 8 Healthcare ... unavailability of resources as the region,s working population is far lower ... introduction of new schemes in healthcare that would enable Europe to ... of Information and Communication Technology (ICT) in healthcare is evident from ...
... ... initiative, clinicians at Union Hospital Hong Kong will have access to electronic drug information ... drug information during prescribing are major contributing factors to medication errors. , ... (PRWEB) December 8, 2009 -- ...
... ... Inc.’s new ‘Feel Good’ Light Lenses are innovative decorating pieces to stir up positive ... the popularity of these “Feel Good” Light Lenses has resulted in a website devoted ... ...
... WASHINGTON, Dec. 7 Jon O,Brien, president of Catholics for ... (D-Nebraska) put the policy priorities of the U.S. Catholic bishops ... that the abortion language in the healthcare bill was not ... hardened his stance on the abortion language, stating that he ...
... ... and ATMP Consulting Group, a strategic IT specialist in electronic medical record (EMR) standards, ... management for their EMR applications. , ... Southfield, MI (Vocus) December 7, 2009 -- Secure-24, Inc., a leading ...
Cached Medicine News:Health News:'Sandwich Generation' Avoids Unnecessary Stress While Tending to Aging Senior Parents 2Health News:Frost & Sullivan: E-Healthcare in Western Europe Presents a Significant Market Opportunity for Wireless Technologies 2Health News:Frost & Sullivan: E-Healthcare in Western Europe Presents a Significant Market Opportunity for Wireless Technologies 3Health News:Union Hospital, Hong Kong, Selects First DataBank's Electronic Drug Information in Medication Safety Initiative 2Health News:Union Hospital, Hong Kong, Selects First DataBank's Electronic Drug Information in Medication Safety Initiative 3Health News:The Flag Company, Inc.'s Recently Released “Feel Good” Light Lenses Grows Into Its Own Website 2Health News:The Flag Company, Inc.'s Recently Released “Feel Good” Light Lenses Grows Into Its Own Website 3Health News:Senator Ben Nelson Puts U.S. Bishops' Interests Ahead of Americans' Healthcare Needs 2Health News:Secure-24 and ATMP Consulting Group Launch Partnership for Private Practice Physicians to Meet IT and Electronic Medical Record Standards 2Health News:Secure-24 and ATMP Consulting Group Launch Partnership for Private Practice Physicians to Meet IT and Electronic Medical Record Standards 3
(Date:7/28/2014)... Reportlinker.com announces that a new market ... Portugal Pharmaceuticals and Healthcare Report Q3 ... Includes 3 FREE quarterly updates ... last quarter has led us to revise our ... previously, BMI expects Portugal,s ...
(Date:7/28/2014)... VALLEY, Pa. , July 28, 2014  Air ... reliable, uninterrupted supply of medical oxygen is vital to ... to technical innovations that not only improve the efficiency ... use. Air Products will highlight these systems—including systems for ... that reduce oxygen loss—from August 4-5 at the ...
(Date:7/28/2014)... 28, 2014 Southern Research Institute today ... President and CEO of Southern Research Institute, has ... (CRS) for the 2014-2015 term.  The inauguration took ... 12 in Chicago with ... The Controlled Release Society is an international, ...
Breaking Medicine Technology:Portugal Pharmaceuticals and Healthcare Report Q3 2014 2Portugal Pharmaceuticals and Healthcare Report Q3 2014 3Portugal Pharmaceuticals and Healthcare Report Q3 2014 4Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 2Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 3Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 2Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 3
... VIEW, Calif. , Jan. 28 ChemoCentryx, ... clinical trial of CCX168, an orally-administered small molecule designed ... and very selective compound that specifically targets the C5a ... and a potent driver of the inflammatory response associated ...
... , WARSAW, Ind. , Jan. 28 , ... 7.5% reported over the prior year period (an increase of 2.5% constant currency) ... reported, a decrease of 1.3% from the prior year period, and $1.12 ... , Net Sales of $4.10 billion for the full ...
Cached Medicine Technology:ChemoCentryx Initiates Clinical Trial of CCX168, A Novel Small Molecule C5aR Antagonist for the Treatment of Inflammatory and Autoimmune Diseases 2ChemoCentryx Initiates Clinical Trial of CCX168, A Novel Small Molecule C5aR Antagonist for the Treatment of Inflammatory and Autoimmune Diseases 3ChemoCentryx Initiates Clinical Trial of CCX168, A Novel Small Molecule C5aR Antagonist for the Treatment of Inflammatory and Autoimmune Diseases 4Zimmer Reports Fourth Quarter and 2009 Financial Results 2Zimmer Reports Fourth Quarter and 2009 Financial Results 3Zimmer Reports Fourth Quarter and 2009 Financial Results 4Zimmer Reports Fourth Quarter and 2009 Financial Results 5Zimmer Reports Fourth Quarter and 2009 Financial Results 6Zimmer Reports Fourth Quarter and 2009 Financial Results 7Zimmer Reports Fourth Quarter and 2009 Financial Results 8Zimmer Reports Fourth Quarter and 2009 Financial Results 9Zimmer Reports Fourth Quarter and 2009 Financial Results 10Zimmer Reports Fourth Quarter and 2009 Financial Results 11Zimmer Reports Fourth Quarter and 2009 Financial Results 12Zimmer Reports Fourth Quarter and 2009 Financial Results 13Zimmer Reports Fourth Quarter and 2009 Financial Results 14Zimmer Reports Fourth Quarter and 2009 Financial Results 15Zimmer Reports Fourth Quarter and 2009 Financial Results 16Zimmer Reports Fourth Quarter and 2009 Financial Results 17Zimmer Reports Fourth Quarter and 2009 Financial Results 18Zimmer Reports Fourth Quarter and 2009 Financial Results 19Zimmer Reports Fourth Quarter and 2009 Financial Results 20Zimmer Reports Fourth Quarter and 2009 Financial Results 21Zimmer Reports Fourth Quarter and 2009 Financial Results 22Zimmer Reports Fourth Quarter and 2009 Financial Results 23Zimmer Reports Fourth Quarter and 2009 Financial Results 24Zimmer Reports Fourth Quarter and 2009 Financial Results 25Zimmer Reports Fourth Quarter and 2009 Financial Results 26Zimmer Reports Fourth Quarter and 2009 Financial Results 27
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: