Navigation Links
Tighter tummies: A new way to combat weight gain
Date:3/3/2008

Two cell proteins that relax the gut and help accommodate a big meal have been identified by UCL (University College London) scientists. The proteins could offer a future drug target against weight gain, by preventing the stomach from expanding.

In a paper published in this months issue of the Journal of Pharmacology and Experimental Therapeutics, Dr Brian King and Dr Andrea Townsend-Nicholson explored the molecular basis of relaxations of the gut. In the study, the authors identified two protein receptors P2Y1 and P2Y11 involved in fast and slow relaxations of the gut. These proteins were identified in the guinea pig, but are also present in the human gut, and thus offer the potential as a future target for drug treatment. Further research by the UCL team will focus on the human isoform of the P2Y11 protein receptor.

Dr Brian King of the UCL Department of Neuroscience, Physiology and Pharmacology says: The mechanisms we have identified are important to the normal workings of the stomach - a hollow organ which actively relaxes to help accommodate the size of your meal. The human stomach has a resting internal volume of 75 millilitres but, by relaxing its muscular wall, can expand to an internal volume of two litres or more - a 25-fold increase in the volume it can accept. This expansion is controlled by nerves inside the stomach wall and these nerves release molecules that stimulate the P2Y1 and P2Y11 receptor proteins embedded in muscle cells in the gut wall.

The mechanism of slow relaxation of the stomach might represent a future drug target in the fight to control weight gain and reverse obesity. We are looking to identify drugs that would block the P2Y11 receptor and, therefore, prevent slow relaxation of the stomach. As a result of blocking the P2Y11-based mechanism, meal size would be smaller, offering the person a better chance of regulating their food intake.

This would be a brand new approach to weight control.
'/>"/>

Contact: Jenny Gimpel
j.gimpel@ucl.ac.uk
University College London
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Anthem Blue Cross and Blue Shield Teams with the State of Indiana to Combat Obesity
2. Five Years of VA Health Care for Combat Veterans
3. Nations to Launch Negotiations on Treaty to Combat Illicit Tobacco Trade
4. U.S. on Sidelines as Nations Launch Negotiations on Treaty to Combat Smuggling, Counterfeiting and Other Illicit Trade in Tobacco Products
5. Grapefruit compound may help combat hepatitis C infection
6. ONDCP Launches First Major Initiative to Combat Teen Prescription Drug Abuse
7. Consuming extra virgin olive oil helps to combat degenerative diseases such as cancer
8. Indian medicinal plant Acanthus ilicifolius may combat liver cancer
9. World Vision Index of Concern: Half of Americans Surveyed Said They Would Be Willing to Pay More Taxes to Combat AIDS
10. Global Health Support Service Benchmark Study to Combat Growing Healthcare Costs and Prepare for Likely Health Care Reforms
11. New Academic Analysis Identifies Three Barriers to Achieving Healthy and Achievable Policies to Combat Obesity in America
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... Dennis Thompson HealthDay Reporter ... could be closing in on a "fountain of youth" drug ... health of older adults, a new study suggests. Seniors ... a drug that targets a genetic signaling pathway linked to ... report. The experimental medication, a version of ...
(Date:12/25/2014)... Thousands of transvaginal mesh lawsuits ( ... number of multidistrict litigations currently underway in U.S. District ... reports. According to an Order issued on December 2, ... Status Conference in all of the proceedings on January ... to submit a proposed agenda to the Court by ...
(Date:12/25/2014)... Plugin creators from Pixel Film Studios have ... business presentation tool made specifically for Final Cut ... tool, users can now display their stats and facts ... Studios. “ProFire 5k gives users a multiple options to ... a presentation” , Pixel Film Studios takes the heat ...
(Date:12/25/2014)... CA (PRWEB) December 25, 2014 Each ... visits and 2 million hospital admissions across the nation ... Prevention ). The CDC’s National Hospital Ambulatory Medical ... through a survey conducted in 2010. They estimated that ... visits that resulted in a primary diagnosis of broken ...
(Date:12/24/2014)... Wi (PRWEB) December 25, 2014 AlignLife ... are unable to afford certain items. During the holiday season, ... "We collected over 70 toys," says Dr. Sara Mahalko-Leonhardt, owner ... and staff such joy, knowing that we are able to ... present had it not been for the generosity of our ...
Breaking Medicine News(10 mins):Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 4Health News:Announcing a new ProFire 5k plugin from Pixel Film Studios for Final Cut Pro X Professionals 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 3Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 4Health News:AlignLife of Wauwatosa Brings Joy to Less Fortunate Families 2
... people were admitted to hospital in South Africa on Friday ... contain anthrax powder, police said. ,Inspector Juanita ... office in the district of Alberton, south of Johannesburg, about ... envelope was filled with powder ... At this stage we ...
... John Sundahl has announced that he is going around with pop ... that his romance with Spears began after their meeting at an ... that he knew Spears also loved him, and corroborated his claim ... recently. ,"When I was in the hospital, she ...
... Britney known for her underwear antics display in the public is back ... investor claims he is her new found love. ... new single status the pop diva has been having a ball in ... crotch. This time in LA she was snapped wearing a lacy top ...
... pass, for the latest way to bag a partner is smirting-a ... is a blessing for many singleton smokers who can now experience ... ,This blend of smoking and flirting developed in the countries where ... ,The Irish were the first ones to discover the ...
... was recently organised at Ludhiana's Majestic Park Plaza. ... the pure vegetarian fare cuisine. ,Sabyasachi Chatterjee, the ... we do almost two-three food festivals in a month. At ... which is not being held in any other joint, in ...
... female politician warned Saturday that men must get fully involved ... be defeated. ,"There aren't enough men who ... responsibly, and that kind of (behaviour) compromises the fight," Phumzile ... the International Women's Summit on HIV/AIDS here. ,She ...
Cached Medicine News:Health News:Africa's Men Urged to Step Up AIDS Fight 2
(Date:12/24/2014)... 2014 In response to urgent requests from the Deputy ... Sierra Leone , Direct Relief delivered two 10-bed medical ... treatment of local health workers who contract Ebola while fighting ... care center was constructed for foreign health care workers who ... for local Sierra Leonean health workers. With ...
(Date:12/24/2014)... N.C. , Dec. 23, 2014  Medical Science ... As the key link between the medical device industry ... even more in the coming years as the device ... According to research by benchmarking firm, Best ... can gain an important edge is by harnessing new ...
(Date:12/22/2014)... 22, 2014 NxStage Medical, Inc. (NASDAQ: ... dialysis products, announced today that the U.S. Food ... One™ to perform hemodialysis overnight while the patient ... hemodialysis. NxStage,s® System One is the first and ... this indication. Home nocturnal hemodialysis ...
Breaking Medicine Technology:First Ebola Treatment Unit for Local Health Workers Arrives in Sierra Leone 2Role of Medical Science Liaisons Evolving in Medical Device Sector 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 3
... 2011 Warner Chilcott plc (Nasdaq: WCRX ... seeking to refinance the Company,s existing credit agreement, dated ... Credit Agreement"), by entering into a new credit agreement ... expected to have the effect of extending the maturity ...
... Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX ) today announced ... Annual Health Care Conference on Wednesday, March 9, 2011 at ... Interested parties may access a live webcast of the ... It is recommended that listeners log on ...
Cached Medicine Technology:Warner Chilcott Seeks to Refinance its Existing Credit Agreement 2Warner Chilcott Seeks to Refinance its Existing Credit Agreement 3Onyx Pharmaceuticals to Present at the Cowen and Company 31st Annual Health Care Conference 2
When You Need Optimal Patient Comfort with Minimal Weight at a Nonunion Site...Demand The OrthoPak Noninvasive Bone Growth Stimulator., ,Most Appropriate for the Proximal Femur, Metatarsal/Tarsal...
... Siemens Medical Solutions introduces its new ... system with intuitive patient data management ... lithotripter and urological table. Lithoskop is ... urodiagnostics that covers all applications like ...
... bone growth stimulator for the treatment of ... bone growth stimulator is a useful adjunct ... is already planned or when patient compliance ... is totally surgically implanted, patients are assured ...
... cataract surgery following refractive surgery grows larger ... for surgeons, as calculating IOL power for ... power following RK, ALK, PRK and LASIK ... or topography. For example, keratometry and simulated ...
Medicine Products: