Navigation Links
Tighter tummies: A new way to combat weight gain
Date:3/3/2008

Two cell proteins that relax the gut and help accommodate a big meal have been identified by UCL (University College London) scientists. The proteins could offer a future drug target against weight gain, by preventing the stomach from expanding.

In a paper published in this months issue of the Journal of Pharmacology and Experimental Therapeutics, Dr Brian King and Dr Andrea Townsend-Nicholson explored the molecular basis of relaxations of the gut. In the study, the authors identified two protein receptors P2Y1 and P2Y11 involved in fast and slow relaxations of the gut. These proteins were identified in the guinea pig, but are also present in the human gut, and thus offer the potential as a future target for drug treatment. Further research by the UCL team will focus on the human isoform of the P2Y11 protein receptor.

Dr Brian King of the UCL Department of Neuroscience, Physiology and Pharmacology says: The mechanisms we have identified are important to the normal workings of the stomach - a hollow organ which actively relaxes to help accommodate the size of your meal. The human stomach has a resting internal volume of 75 millilitres but, by relaxing its muscular wall, can expand to an internal volume of two litres or more - a 25-fold increase in the volume it can accept. This expansion is controlled by nerves inside the stomach wall and these nerves release molecules that stimulate the P2Y1 and P2Y11 receptor proteins embedded in muscle cells in the gut wall.

The mechanism of slow relaxation of the stomach might represent a future drug target in the fight to control weight gain and reverse obesity. We are looking to identify drugs that would block the P2Y11 receptor and, therefore, prevent slow relaxation of the stomach. As a result of blocking the P2Y11-based mechanism, meal size would be smaller, offering the person a better chance of regulating their food intake.

This would be a brand new approach to weight control. At present, the most successful way to help obese patients lose weight is gastric banding or stomach stapling, both of which reduce the maximum volume of the stomach. But these are also tricky surgical procedures, not without attendant risks. A pill that could replace this surgery, yet have the same effect, might be a useful alternative.


'/>"/>

Contact: Jenny Gimpel
j.gimpel@ucl.ac.uk
University College London
Source:Eurekalert

Related medicine news :

1. Anthem Blue Cross and Blue Shield Teams with the State of Indiana to Combat Obesity
2. Five Years of VA Health Care for Combat Veterans
3. Nations to Launch Negotiations on Treaty to Combat Illicit Tobacco Trade
4. U.S. on Sidelines as Nations Launch Negotiations on Treaty to Combat Smuggling, Counterfeiting and Other Illicit Trade in Tobacco Products
5. Grapefruit compound may help combat hepatitis C infection
6. ONDCP Launches First Major Initiative to Combat Teen Prescription Drug Abuse
7. Consuming extra virgin olive oil helps to combat degenerative diseases such as cancer
8. Indian medicinal plant Acanthus ilicifolius may combat liver cancer
9. World Vision Index of Concern: Half of Americans Surveyed Said They Would Be Willing to Pay More Taxes to Combat AIDS
10. Global Health Support Service Benchmark Study to Combat Growing Healthcare Costs and Prepare for Likely Health Care Reforms
11. New Academic Analysis Identifies Three Barriers to Achieving Healthy and Achievable Policies to Combat Obesity in America
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2017)... ... February 23, 2017 , ... ... partnership with The Jensie Gran Fondo of Marin. For the second year in ... Thinksport’s broad-spectrum, mineral-based sunscreen. , “We are thrilled to provide our safe, non-toxic ...
(Date:2/23/2017)... , ... February 23, 2017 , ... ... of Justice jointly issued a letter to withdraw previous guidance issued ... their gender identity. The guidance issued in May 2016 by the Obama Administration ...
(Date:2/23/2017)... ... 23, 2017 , ... The 89th Academy Awards will be celebrated this weekend, ... Policy Center Bunkum Award. We invite you to enjoy our 11th annual tongue-in-cheek “salute” ... is the Center for American Progress (CAP), for its report, Lessons From State Performance ...
(Date:2/23/2017)... ... February 23, 2017 , ... The Lymphoma Research ... lymphoma research and serving the lymphoma community through a comprehensive series of education ... Country Club in Miami Beach to host its Swirl: Miami Wine Tasting Event ...
(Date:2/23/2017)... ... February 23, 2017 , ... Rare Disease Report®, ... be participating in Rare Disease Day events, hosted by the Rare Disease Legislative ... Report, a website, weekly e-newsletter and quarterly publication, will be conducting interviews with ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... BOSTON , Feb. 23, 2017 ... devices and services since 1997, is changing the ... modern technology providing patients with pro-active, custom-made solutions. ... desire for instant and affordable healthcare without walls, ... of high-level devices developed with healthcare professionals that ...
(Date:2/23/2017)... Research and Markets has announced the addition ... - 2016" report to their offering. ... The latest research Autism Spectrum Disorder ... and benchmarks in the global Autism Spectrum Disorder market. The ... are the key drugs marketed for Autism Spectrum Disorder and their ...
(Date:2/23/2017)... -- Genesis Healthcare Services has merged with Hospice Cloud, a ... Bill Monast , President and CEO of Hospice Cloud ... , executives with Home Health Depot, Inc., the parent ... This acquisition helps Hospice Cloud maintain its position as ... equipment (DME) solutions for the hospice industry. Nathan ...
Breaking Medicine Technology: