Navigation Links
Tighter tummies: A new way to combat weight gain

Two cell proteins that relax the gut and help accommodate a big meal have been identified by UCL (University College London) scientists. The proteins could offer a future drug target against weight gain, by preventing the stomach from expanding.

In a paper published in this months issue of the Journal of Pharmacology and Experimental Therapeutics, Dr Brian King and Dr Andrea Townsend-Nicholson explored the molecular basis of relaxations of the gut. In the study, the authors identified two protein receptors P2Y1 and P2Y11 involved in fast and slow relaxations of the gut. These proteins were identified in the guinea pig, but are also present in the human gut, and thus offer the potential as a future target for drug treatment. Further research by the UCL team will focus on the human isoform of the P2Y11 protein receptor.

Dr Brian King of the UCL Department of Neuroscience, Physiology and Pharmacology says: The mechanisms we have identified are important to the normal workings of the stomach - a hollow organ which actively relaxes to help accommodate the size of your meal. The human stomach has a resting internal volume of 75 millilitres but, by relaxing its muscular wall, can expand to an internal volume of two litres or more - a 25-fold increase in the volume it can accept. This expansion is controlled by nerves inside the stomach wall and these nerves release molecules that stimulate the P2Y1 and P2Y11 receptor proteins embedded in muscle cells in the gut wall.

The mechanism of slow relaxation of the stomach might represent a future drug target in the fight to control weight gain and reverse obesity. We are looking to identify drugs that would block the P2Y11 receptor and, therefore, prevent slow relaxation of the stomach. As a result of blocking the P2Y11-based mechanism, meal size would be smaller, offering the person a better chance of regulating their food intake.

This would be a brand new approach to weight control. At present, the most successful way to help obese patients lose weight is gastric banding or stomach stapling, both of which reduce the maximum volume of the stomach. But these are also tricky surgical procedures, not without attendant risks. A pill that could replace this surgery, yet have the same effect, might be a useful alternative.


Contact: Jenny Gimpel
University College London

Related medicine news :

1. Anthem Blue Cross and Blue Shield Teams with the State of Indiana to Combat Obesity
2. Five Years of VA Health Care for Combat Veterans
3. Nations to Launch Negotiations on Treaty to Combat Illicit Tobacco Trade
4. U.S. on Sidelines as Nations Launch Negotiations on Treaty to Combat Smuggling, Counterfeiting and Other Illicit Trade in Tobacco Products
5. Grapefruit compound may help combat hepatitis C infection
6. ONDCP Launches First Major Initiative to Combat Teen Prescription Drug Abuse
7. Consuming extra virgin olive oil helps to combat degenerative diseases such as cancer
8. Indian medicinal plant Acanthus ilicifolius may combat liver cancer
9. World Vision Index of Concern: Half of Americans Surveyed Said They Would Be Willing to Pay More Taxes to Combat AIDS
10. Global Health Support Service Benchmark Study to Combat Growing Healthcare Costs and Prepare for Likely Health Care Reforms
11. New Academic Analysis Identifies Three Barriers to Achieving Healthy and Achievable Policies to Combat Obesity in America
Post Your Comments:
(Date:6/26/2016)... Carolina (PRWEB) , ... June 26, 2016 , ... ... of a new product that was developed to enhance the health of felines. The ... centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can ... Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey ... cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under ...
(Date:6/25/2016)... , ... June 25, 2016 , ... As a lifelong ... Cum Laude and his M.D from the David Geffen School of Medicine at UCLA. ... to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai ...
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Capricor Therapeutics, Inc. ... biotechnology company focused on the discovery, development and ... enrollment in its ongoing randomized HOPE-Duchenne clinical trial ... of its 24-patient target. Capricor expects the trial ... of 2016, and to report top line data ...
(Date:6/23/2016)... BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a ... second affiliate in Latin America . ... ... ... ...
(Date:6/23/2016)... 23, 2016  Experian Health, the healthcare ... the patient payment and care experience, today ... products and services that will enhance the ... offerings. These award-winning solutions will enable healthcare ... compliant in an ever-changing environment and redefine ...
Breaking Medicine Technology: