Navigation Links
Thyroid project sheds light on molecular processes related to cystic fibrosis
Date:10/29/2013

MANHATTAN, Kan. -- Research in the College of Veterinary Medicine at Kansas State University is leading to a better understanding of the molecular interactions in the thyroid gland related to cystic fibrosis.

A genetic disorder, cystic fibrosis affects the function of epithelia, the tissues formed of cells that secrete and absorb an array of substances important for health.

The university's Peying Fong, associate professor of anatomy and physiology, has received a $285,000 grant from the Department of Health and Human Services in support of her study, "CFTR Regulation of Thyroid Transport."

"We are looking at a cellular mechanism that is essential to production of thyroxine and triiodothyronine, which are hormones that modulate development, growth and metabolism in both prenatal and postnatal cell life," Fong said. "Iodide is an essential component of these thyroid hormones. Its rarity in the environment challenges the thyroid to orchestrate a remarkable series of transport processes that are critical for hormone synthesis."

In addition to actively extracting iodidethrough the circulation process, thyroid cells must also translocate iodide into a central compartment within thyroid follicles, where it begins to combine with thyroglobulin to form the precursor to thyroid hormone.

"Through this study, we are seeking to better understand the molecular interactions between the Cystic Fibrosis Transmembrane Conductance Regulator, or CFTR, and SLC5A8, which are two transport proteins found in thyroid," Fong said. "These proteins may play a role in moving iodide into the follicular lumen."

Fong's project is classified by the National Institutes of Health as an R15 Academic Research Enhancement Award. The NIH uses such awards to strengthen research environments at educational institutions as well as to promote the exposure of students to academic research. This is a renewable grant and helps cover expenses for a period of up to three years.

Fong said that the groundwork for her research project originally began with funding from the Kansas State University's Center of Biomedical Research Excellence, or COBRE, and NIH project "Epithelial Function in Health and Disease"; a grant-in-aid from the American Heart Association Midwest Affiliate; and an Innovative Research Award from the university's Johnson Center for Basic Cancer Research.


'/>"/>

Contact: Peying Fong
pfong@vet.k-state.edu
785-532-4524
Kansas State University
Source:Eurekalert  

Related medicine news :

1. Thyroid Condition Linked to Heart Problems: Study
2. Lower-Dose Radioiodine Effective Against Thyroid Cancer
3. Staging and risk stratification of thyroid cancer improved with SPECT/CT
4. Obese More Likely to Be Diagnosed With Advanced Thyroid Cancer
5. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
6. Hyperthyroidism linked to increased risk of hospitalization for heart and blood-vessel disease
7. Gene expression test identifies low-risk thyroid nodules
8. Detecting thyroid disease by computer
9. Experts issue recommendations for treating thyroid dysfunction during and after pregnancy
10. Drug May Aid People With Advanced Thyroid Cancer
11. Thyroid Treatment Guidelines for Pregnant Women Revised
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Thyroid project sheds light on molecular processes related to cystic fibrosis
(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding ... of its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. ... James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of indulgence ... high can result in disappointment, perhaps even self-loathing. However, those who set the bar ... from PsychTests.com reveals that behind the tendency to set low expectations is ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... To deal with these feelings, many turn to unhealthy avenues, such as drug or ... Center of Marne, Michigan, has released tools for healthy coping following a traumatic event. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- The Academy of Managed Care Pharmacy (AMCP) today ... allow biopharmaceutical companies to more easily share health care ... coverage decisions, a move that addresses the growing need ... The recommendations address restrictions in the sharing of product ... a prohibition that hinders decision makers from accessing HCEI ...
(Date:6/24/2016)... June 24, 2016 According to ... Type (Standard Pen Needles, Safety Pen Needles), Needle Length ... Growth Hormone), Mode of Purchase (Retail, Non-Retail) - Trends ... report studies the market for the forecast period of ... USD 2.81 Billion by 2021 from USD 1.65 Billion ...
(Date:6/23/2016)... HOUSTON , June 23, 2016  MedSource ... platform as its e-clinical software solution of choice.  ... the best possible value to their clients by ... nowEDC.  The preferred relationship establishes nowEDC as the ... pricing for MedSource,s full-service clients.  "nowEDC has long ...
Breaking Medicine Technology: