Navigation Links
Thyroid project sheds light on molecular processes related to cystic fibrosis

MANHATTAN, Kan. -- Research in the College of Veterinary Medicine at Kansas State University is leading to a better understanding of the molecular interactions in the thyroid gland related to cystic fibrosis.

A genetic disorder, cystic fibrosis affects the function of epithelia, the tissues formed of cells that secrete and absorb an array of substances important for health.

The university's Peying Fong, associate professor of anatomy and physiology, has received a $285,000 grant from the Department of Health and Human Services in support of her study, "CFTR Regulation of Thyroid Transport."

"We are looking at a cellular mechanism that is essential to production of thyroxine and triiodothyronine, which are hormones that modulate development, growth and metabolism in both prenatal and postnatal cell life," Fong said. "Iodide is an essential component of these thyroid hormones. Its rarity in the environment challenges the thyroid to orchestrate a remarkable series of transport processes that are critical for hormone synthesis."

In addition to actively extracting iodidethrough the circulation process, thyroid cells must also translocate iodide into a central compartment within thyroid follicles, where it begins to combine with thyroglobulin to form the precursor to thyroid hormone.

"Through this study, we are seeking to better understand the molecular interactions between the Cystic Fibrosis Transmembrane Conductance Regulator, or CFTR, and SLC5A8, which are two transport proteins found in thyroid," Fong said. "These proteins may play a role in moving iodide into the follicular lumen."

Fong's project is classified by the National Institutes of Health as an R15 Academic Research Enhancement Award. The NIH uses such awards to strengthen research environments at educational institutions as well as to promote the exposure of students to academic research. This is a renewable grant and helps cover expenses for a period of up to three years.

Fong said that the groundwork for her research project originally began with funding from the Kansas State University's Center of Biomedical Research Excellence, or COBRE, and NIH project "Epithelial Function in Health and Disease"; a grant-in-aid from the American Heart Association Midwest Affiliate; and an Innovative Research Award from the university's Johnson Center for Basic Cancer Research.


Contact: Peying Fong
Kansas State University

Related medicine news :

1. Thyroid Condition Linked to Heart Problems: Study
2. Lower-Dose Radioiodine Effective Against Thyroid Cancer
3. Staging and risk stratification of thyroid cancer improved with SPECT/CT
4. Obese More Likely to Be Diagnosed With Advanced Thyroid Cancer
5. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
6. Hyperthyroidism linked to increased risk of hospitalization for heart and blood-vessel disease
7. Gene expression test identifies low-risk thyroid nodules
8. Detecting thyroid disease by computer
9. Experts issue recommendations for treating thyroid dysfunction during and after pregnancy
10. Drug May Aid People With Advanced Thyroid Cancer
11. Thyroid Treatment Guidelines for Pregnant Women Revised
Post Your Comments:
Related Image:
Thyroid project sheds light on molecular processes related to cystic fibrosis
(Date:11/25/2015)... ... November 25, 2015 , ... “While riding the bus, I ... Bronx, N.Y. “I thought there had to be a convenient and comfortable way to ... The PROTECTOR enables disabled individuals to safely travel during cold or inclement weather. In ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... (PHA) announces the nation’s Periwinkle Pioneers, individuals and groups responsible for advancing care ... disease. The Periwinkle Pioneers, nominated by the public, will receive special recognition throughout ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... philanthropic seniors, is resulting in a way for homeless people to have a ... have launched a new initiative whereby they are repurposing plastic bags into sleeping ...
(Date:11/25/2015)... ... November 25, 2015 , ... Since its launch in 2012, ... adult stem cell therapies to patients with chronic degenerative medical conditions. Now, the ... Registered Trademark (RTM). , Organizations are required to hold a registered trademark in ...
(Date:11/24/2015)... ... November 25, 2015 , ... Genesis Chiropractic Software ... software creates an agreement between the practice owner and the patient that automatically ... notification, and projections. Click here to learn more. , ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... FRANCISCO , Nov. 24, 2015  Thanks to ... Dignity Health St. Mary,s Medical Center,s Sister Diane Grassilli ... breast imaging capabilities in San Francisco ... an anonymous friend, stepped forward with a gift of ... for Breast Digital Mammography with Tomosynthesis and Whole Breast ...
(Date:11/24/2015)... Colo. , Nov. 24, 2015  Array ... that its Chief Executive Officer, Ron Squarer ... Healthcare Conference in New York.  The public is ... webcast on the Array BioPharma website.Event:Piper Jaffray Annual ... , Wednesday, December 2, 2015Time:1:30 p.m. Eastern Time ...
(Date:11/24/2015)... HOUSTON, TX and VANCOUVER, Nov. 24, 2015 /PRNewswire/ ... EPI; NASDAQ: EPIX ) announced today that the ... clinical study of EPI-506 as a treatment for metastatic ... States and Canada.  --> ... --> In the Phase 1/2 clinical trial, ...
Breaking Medicine Technology: