Navigation Links
Thyroid project sheds light on molecular processes related to cystic fibrosis
Date:10/29/2013

MANHATTAN, Kan. -- Research in the College of Veterinary Medicine at Kansas State University is leading to a better understanding of the molecular interactions in the thyroid gland related to cystic fibrosis.

A genetic disorder, cystic fibrosis affects the function of epithelia, the tissues formed of cells that secrete and absorb an array of substances important for health.

The university's Peying Fong, associate professor of anatomy and physiology, has received a $285,000 grant from the Department of Health and Human Services in support of her study, "CFTR Regulation of Thyroid Transport."

"We are looking at a cellular mechanism that is essential to production of thyroxine and triiodothyronine, which are hormones that modulate development, growth and metabolism in both prenatal and postnatal cell life," Fong said. "Iodide is an essential component of these thyroid hormones. Its rarity in the environment challenges the thyroid to orchestrate a remarkable series of transport processes that are critical for hormone synthesis."

In addition to actively extracting iodidethrough the circulation process, thyroid cells must also translocate iodide into a central compartment within thyroid follicles, where it begins to combine with thyroglobulin to form the precursor to thyroid hormone.

"Through this study, we are seeking to better understand the molecular interactions between the Cystic Fibrosis Transmembrane Conductance Regulator, or CFTR, and SLC5A8, which are two transport proteins found in thyroid," Fong said. "These proteins may play a role in moving iodide into the follicular lumen."

Fong's project is classified by the National Institutes of Health as an R15 Academic Research Enhancement Award. The NIH uses such awards to strengthen research environments at educational institutions as well as to promote the exposure of students to academic research. This is a renewable grant and helps cover expenses for a period of up to three years.

Fong said that the groundwork for her research project originally began with funding from the Kansas State University's Center of Biomedical Research Excellence, or COBRE, and NIH project "Epithelial Function in Health and Disease"; a grant-in-aid from the American Heart Association Midwest Affiliate; and an Innovative Research Award from the university's Johnson Center for Basic Cancer Research.


'/>"/>

Contact: Peying Fong
pfong@vet.k-state.edu
785-532-4524
Kansas State University
Source:Eurekalert  

Related medicine news :

1. Thyroid Condition Linked to Heart Problems: Study
2. Lower-Dose Radioiodine Effective Against Thyroid Cancer
3. Staging and risk stratification of thyroid cancer improved with SPECT/CT
4. Obese More Likely to Be Diagnosed With Advanced Thyroid Cancer
5. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
6. Hyperthyroidism linked to increased risk of hospitalization for heart and blood-vessel disease
7. Gene expression test identifies low-risk thyroid nodules
8. Detecting thyroid disease by computer
9. Experts issue recommendations for treating thyroid dysfunction during and after pregnancy
10. Drug May Aid People With Advanced Thyroid Cancer
11. Thyroid Treatment Guidelines for Pregnant Women Revised
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Thyroid project sheds light on molecular processes related to cystic fibrosis
(Date:1/20/2017)... ... 20, 2017 , ... “I Forgive You”: a fine examination of how God handles sin, ... creation of published author, Stephen Miller, who, for over ten long years has been waiting ... Born in Trinidad and Tobago, he has been serving the Lord for over twenty years, ...
(Date:1/20/2017)... ... January 20, 2017 , ... “The Land of More and More”: a ... world hunger, and shares the simple and achievable answer. “The Land of More and ... the Fairview Missionary Church in Angola, Indiana where he works with the children’s ministry ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... and facility enhancement of their 503A compounding pharmacy located in Ocala, Florida. ... of physicians and patients throughout the United States for high-quality human anti-aging ...
(Date:1/19/2017)... ... January 19, 2017 , ... Remote Medical Technologies ... impressive transportable capabilities with their iMedHD2™ Portable Teleultrasound System. Compatible ... technology that delivers HD, dynamic, streaming ultrasound images and video to one or ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... announced it recently provided a new $11,250,000 senior credit facility to Sunrise, Florida-based ... MB credit facility were used to facilitate a recapitalization of MedPro led by ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... N.J. , Jan. 19, 2017 Many ... $100 for their medication when a pharmacy just a ... exact prescription.  To alleviate this problem Medicationdiscountcard.com ... patients to see exactly how much their medication will ... Shopping Made Easy ...
(Date:1/19/2017)... Jan. 19, 2017  Abaxis, Inc. (NasdaqGS: ... analysis instruments and consumables for the medical and veterinary ... its financial results for the third quarter fiscal year ... at 4:15 p.m. ET on Thursday, January 26, 2017.  ... quarter fiscal year 2017 after the market closes on ...
(Date:1/19/2017)... , Jan. 19, 2017   Science Exchange ... excited to announce that the first five replication ...  (RP:CB) have been published in eLife today. Despite ... represents the first practical evaluation of reproducibility rates ... reproducible studies. Unlike other assessments of reproducibility, the ...
Breaking Medicine Technology: