Navigation Links
Thyroid hormones reduce damage and improve heart function after myocardial infarction in rats
Date:2/28/2013

Thyroid hormone treatment administered to rats at the time of a heart attack (myocardial infarction) led to significant reduction in the loss of heart muscle cells and improvement in heart function, according to a study published by a team of researchers led by A. Martin Gerdes and Yue-Feng Chen from New York Institute of Technology College of Osteopathic Medicine.

The findings, published in the Journal of Translational Medicine, have bolstered the researchers' contention that thyroid hormones may help reduce heart damage in humans with cardiac diseases.

"I am extremely excited about the prospects of improving heart disease outcomes in patients by restoring normal thyroid function in the heart," says Gerdes, professor and chair of biomedical sciences at New York Institute of Technology College of Osteopathic Medicine. "Since thyroid hormones are inexpensive, significant health care savings could also result."

In the study, funded by the National Institutes of Health's National Heart, Lung, and Blood Institute and the American Heart Association, scientists treated rats with thyroid hormones after myocardial infarction and examined changes at the cellular level. After eight weeks of treatment, researchers saw significant improvements in heart function and a reduction in the loss of cardiac myocytes, the cells responsible for the heart's pumping ability.

"Reducing the loss of cardiac myocytes is a major therapeutic target after a heart attack since this should lead to improved patient survival and reduced disability," Gerdes said.

Gerdes, who has conducted heart failure research for 35 years, has focused on the two major forms of thyroid hormones known as T3 and T4. Previous animal studies have shown that myocardial infarction leads to reduced cardiac levels of T3, a change that animal studies have demonstrated can eventually cause heart failure by itself. However, blood hormone levels may not always reflect this cardiac tissue deficiency. Although tissue T3 levels have not yet been measured in human hearts, available evidence suggests the same hormone loss likely occurs after myocardial infarction.

"This study clearly demonstrates dramatic benefits in a rat model of myocardial infarction. The challenge now is to determine if humans benefit similarly," says Gerdes.

Gerdes noted that many physicians are opposed to treating heart patients with thyroid hormones, largely due to the potential of increased arrhythmias from overdosing.

"We need to conduct more research to determine which form, T3 or T4, works best in humans and how to administer and monitor hormone treatment in a manner that restores cardiac T3 without increasing serum hormones to above normal levels," he said. "We are encouraged because all animal models of heart disease studied to this point have produced beneficial results as long as non-toxic doses are used. More recently, we have also developed a treatment approach in rats that restores cardiac tissue T3 while maintaining blood hormone levels within the normal range. This is an approach that should also work in humans. So, I believe we are now better prepared for clinical trials."


'/>"/>

Contact: Elaine Iandoli
eiandoli@nyit.edu
516-686-4013
New York Institute of Technology
Source:Eurekalert

Related medicine news :

1. HypothyroidMom.com Reveals Research Linking Hypothyroidism to the Deadliest Diseases of Our Time
2. Terris co-edits first textbook on thyroid surgery complications
3. HypothyroidMom.com Launches Thyroid Advocacy Site for Moms with Hypothyroidism
4. Mayo Clinic: 2-drug combination may slow deadly thyroid cancer
5. Overactive Thyroid May Raise Risk for Common Irregular Heartbeat
6. BPA shown to disrupt thyroid function in pregnant animals and offspring
7. Vandetanib in thyroid cancer: No proof of added benefit
8. First comprehensive guidelines for managing anaplastic thyroid cancer published in Thyroid journal
9. Mild Hyperthyroidism Wont Raise Heart Risk: Study
10. Poorer Patients Find Thyroid Cancer at Later Stage: Study
11. Mild increases in thyroid-stimulating hormone not harmful in the elderly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to ... app. The fitness app plans to fix the two major problems leading the fitness industry ... fits all type program , They don’t eliminate all the reasons people quit ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library ... City Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ... for fumigation is not a common occurrence, but a necessary one in the event that ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. ... from injury. Recently, he has implemented orthobiologic procedures as a method for treating ... one of the first doctors to perform the treatment. Orthobiologics are substances that ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
(Date:6/24/2016)... ... , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys ... peers for this recognition are considered among the top 2 percent of lawyers practicing ... members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Research and Markets has announced the addition ... to their offering. The ... commercial environment for MedImmune to enter. The US ageing population ... to drive considerable growth for effective anti-influenza medications. The introduction ... considerably, but development is still in its infancy. ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, 2016 ... Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, the ... announced today online at www.diabetesscholars.org by the ... diabetes stand in the way of academic and community ... Foundation,s scholarship program since 2012, and continues to advocate ...
(Date:6/23/2016)... June 23, 2016  Guerbet announced today that it ... Supplier Horizon Award . One of 12 ... recognized for its support of Premier members through exceptional ... excellence, and commitment to lower costs. ... recognition of our outstanding customer service from Premier," says ...
Breaking Medicine Technology: