Navigation Links
Thyroid hormones reduce damage and improve heart function after myocardial infarction in rats

Thyroid hormone treatment administered to rats at the time of a heart attack (myocardial infarction) led to significant reduction in the loss of heart muscle cells and improvement in heart function, according to a study published by a team of researchers led by A. Martin Gerdes and Yue-Feng Chen from New York Institute of Technology College of Osteopathic Medicine.

The findings, published in the Journal of Translational Medicine, have bolstered the researchers' contention that thyroid hormones may help reduce heart damage in humans with cardiac diseases.

"I am extremely excited about the prospects of improving heart disease outcomes in patients by restoring normal thyroid function in the heart," says Gerdes, professor and chair of biomedical sciences at New York Institute of Technology College of Osteopathic Medicine. "Since thyroid hormones are inexpensive, significant health care savings could also result."

In the study, funded by the National Institutes of Health's National Heart, Lung, and Blood Institute and the American Heart Association, scientists treated rats with thyroid hormones after myocardial infarction and examined changes at the cellular level. After eight weeks of treatment, researchers saw significant improvements in heart function and a reduction in the loss of cardiac myocytes, the cells responsible for the heart's pumping ability.

"Reducing the loss of cardiac myocytes is a major therapeutic target after a heart attack since this should lead to improved patient survival and reduced disability," Gerdes said.

Gerdes, who has conducted heart failure research for 35 years, has focused on the two major forms of thyroid hormones known as T3 and T4. Previous animal studies have shown that myocardial infarction leads to reduced cardiac levels of T3, a change that animal studies have demonstrated can eventually cause heart failure by itself. However, blood hormone levels may not always reflect this cardiac tissue deficiency. Although tissue T3 levels have not yet been measured in human hearts, available evidence suggests the same hormone loss likely occurs after myocardial infarction.

"This study clearly demonstrates dramatic benefits in a rat model of myocardial infarction. The challenge now is to determine if humans benefit similarly," says Gerdes.

Gerdes noted that many physicians are opposed to treating heart patients with thyroid hormones, largely due to the potential of increased arrhythmias from overdosing.

"We need to conduct more research to determine which form, T3 or T4, works best in humans and how to administer and monitor hormone treatment in a manner that restores cardiac T3 without increasing serum hormones to above normal levels," he said. "We are encouraged because all animal models of heart disease studied to this point have produced beneficial results as long as non-toxic doses are used. More recently, we have also developed a treatment approach in rats that restores cardiac tissue T3 while maintaining blood hormone levels within the normal range. This is an approach that should also work in humans. So, I believe we are now better prepared for clinical trials."


Contact: Elaine Iandoli
New York Institute of Technology

Related medicine news :

1. Reveals Research Linking Hypothyroidism to the Deadliest Diseases of Our Time
2. Terris co-edits first textbook on thyroid surgery complications
3. Launches Thyroid Advocacy Site for Moms with Hypothyroidism
4. Mayo Clinic: 2-drug combination may slow deadly thyroid cancer
5. Overactive Thyroid May Raise Risk for Common Irregular Heartbeat
6. BPA shown to disrupt thyroid function in pregnant animals and offspring
7. Vandetanib in thyroid cancer: No proof of added benefit
8. First comprehensive guidelines for managing anaplastic thyroid cancer published in Thyroid journal
9. Mild Hyperthyroidism Wont Raise Heart Risk: Study
10. Poorer Patients Find Thyroid Cancer at Later Stage: Study
11. Mild increases in thyroid-stimulating hormone not harmful in the elderly
Post Your Comments:
(Date:6/24/2016)... ... June 24, 2016 , ... ... Scientific Sessions in Dallas that it will receive two significant new grants to ... came as PHA marked its 25th anniversary by recognizing patients, medical professionals and ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway ... call for a minimum wage raise to $12 an hour by 2020 and then adjusting ... restore the lost value of the minimum wage, assure the wage floor does not erode ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented its ... Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor the outstanding ... Medicine Practice and Pediatric Emergency Medicine Practice. , “With this award, we ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative Solutions ... initiated cultivation and processing operations at its production facility, and opened its first ... is the manufacturer of a complete system of proactive air and surface purification ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 The Academy of ... recommendations that would allow biopharmaceutical companies to ... entities that make formulary and coverage decisions, a move ... of new medicines. The recommendations address restrictions ... appear on the drug label, a prohibition that hinders ...
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
(Date:6/23/2016)... 23, 2016  MedSource announced today that it ... software solution of choice.  This latest decision demonstrates ... to their clients by offering a state-of-the-art electronic ... establishes nowEDC as the EDC platform of choice ... clients.  "nowEDC has long been a preferred EDC ...
Breaking Medicine Technology: