Navigation Links
Thyroid hormone analogue for treating high cholesterol
Date:3/11/2010

MANHASSET, NY An experimental thyroid drug reduces cholesterol without the troublesome side effects experienced by some people on statins, according to a study published today in The New England Journal of Medicine. An international team of investigators at Johns Hopkins Medical Institutions, the Karolinska University Hospital and Institute, and The Feinstein Institute for Medical Research tested a substance called Eprotirome in patients with high cholesterol.

Following 189 people with high cholesterol over a three-month period, they observed that it lowered cholesterol levels without the classic thyroid risks to the heart and bone, The study was supported by Karo Bio in Sweden, a company that is developing the drug for its cholesterol-lowering effects.

Over three decades, Irwin Klein, MD, an endocrinologist at the Feinstein Institute, has been at the forefront of researching the connection between thyroid and heart health. It seemed that people with underactive thyroid glands also had high cholesterol levels. These high cholesterol levels were dramatically reduced with thyroid hormone replacement. But the problem in using thyroid hormone for cholesterol lowering is the side effects of an overactive thyroid gland: people can become anxious and have heart palpitations, muscle weakness and bone thinning.

Scientists spent years trying to develop thyroid analogs that lowered lipids without unwanted side effects. American scientists, including Dr. Klein and John D. Baxter, MD, a senior member of The Methodist Hospital Research Institute, have been working with Karo Bio scientists to solve this problem. They landed on one in particular that lowered cholesterol without any of the problems with the traditional thyroid medicines. Phase I studies showed the drug safe.

In the current Phase II study, they reported that it was both safe and effective in lowering cholesterol. What is not known from this study is whether this lowering of cholesterol will ultimately protect patients from heart disease. Dr. Klein said he thinks it may work to reduce cardiovascular disease. "Every percentage that you lower cholesterol, you lower the risk for heart disease," he said. "High cholesterol is the single most modifiable risk factor." About one in three people have cholesterol levels that are higher than the national guidelines set by federal agencies.

Jens Kristensen, a scientist at Karo Bio and the lead author on the study, and his colleagues also found that the experimental medicine lowered a cholesterol product in the blood called lipoprotein A, which is damaging to the heart. There are no available medicines that lower lipoprotein A and Eprotirome lowered the levels by 33 percent.

Since cholesterol lowering is a surrogate marker for heart disease, the scientists will have to conduct other studies to test whether it does in fact reduce heart disease. The next phase of testing must include larger numbers of patients. If the results hold, it could ultimately be used as an alternative to statins. A small percentage of patients can't take statins, either because they don't work to lower cholesterol for them or they suffer from unrelenting side effects such as muscle pains, myopathy and tiredness.


'/>"/>

Contact: Jamie Talan
jtalan@nshs.edu
516-562-1232
North Shore-Long Island Jewish (LIJ) Health System
Source:Eurekalert

Related medicine news :

1. Thyroid Hormone Analogue for Treating High Cholesterol
2. Thyroid Disease: The Hidden Epidemic
3. No End In Sight To The Armour Thyroid Shortage?
4. Stain repellent chemical linked to thyroid disease in adults
5. It's January...Do You Know Where Your Thyroid Is? Thyroid Awareness Month Focuses on Millions of Undiagnosed Americans with Thyroid Problems
6. Low Thyroid Levels May Up Need for Assisted Delivery
7. Pregnancy Complication May Be Linked to Thyroid Problems
8. Thyroid Cancer Higher in Volcanic Areas
9. Newly revised guidelines for managing thyroid cancer published in Thyroid journal
10. Thyroid surgery safe for older patients, study finds
11. Studies Evaluate Thyroid Treatment During Pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... 2016 , ... The Valentine’s Season is famous for gift giving with flowers, chocolates and other ... loved. This year, for more than 5.6 million Americans suffering with Alzheimer’s, those store ... to remind them of the lives they’ve led and the people they’ve touched. ...
(Date:2/8/2016)... ... 08, 2016 , ... Tingley Rubber Corporation , a ... its range of unique and advantaged protective solutions to a growing and ... bilingual customer service and marketing support. A new distribution center in Brampton, Ontario ...
(Date:2/8/2016)... ... February 08, 2016 , ... Delta Dental of California ... combat pancreatic cancer. , Gary D. Radine, who recently retired as president and CEO ... Cancer Society’s 2015 CEO of the Year , helped lead the effort to ...
(Date:2/8/2016)... , ... February 08, 2016 , ... ... wide variety of organizations. DocuSyst provides a cloud hosted environment for FileHold ... installations include integration with various 3rd party applications using the FileHold web services ...
(Date:2/8/2016)... , ... February 08, 2016 , ... TopConsumerReviews.com recently awarded ... Mole removal products. , Moles are derived from a cluster of melanin when exposed ... the wrong places and create a lifetime of embarrassment. Historically, mole removal ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... CITY, Calif., Feb. 8, 2016  Aoxing Pharmaceutical Company, Inc. (NYSE ... fiscal year 2016, ended December 31, 2015, the Company achieved ... recorded in the same quarter in fiscal 2015. ... in Q2 of fiscal year 2016 was $2,068,635, or $.03 ... or $.01 per share, in the Q2 of fiscal year ...
(Date:2/8/2016)... Feb. 8, 2016 ... of the "Label-Free Detection Market by ... 2020" report to their offering. ... addition of the "Label-Free Detection Market ... to 2020" report to their offering. ...
(Date:2/8/2016)...  HemaFlo Therapeutics, Inc. announced today that the United States ... 9,119,880 covering the use of NephroFlow to treat acute kidney ... founder, said, "We are pleased to secure our rights to ... , PhD, HemaFlo,s founder, said, "We are pleased to secure ... Dale Peterson , PhD, HemaFlo,s founder, said, "We ...
Breaking Medicine Technology: