Navigation Links
Thyroid hormone analogue for treating high cholesterol
Date:3/11/2010

MANHASSET, NY An experimental thyroid drug reduces cholesterol without the troublesome side effects experienced by some people on statins, according to a study published today in The New England Journal of Medicine. An international team of investigators at Johns Hopkins Medical Institutions, the Karolinska University Hospital and Institute, and The Feinstein Institute for Medical Research tested a substance called Eprotirome in patients with high cholesterol.

Following 189 people with high cholesterol over a three-month period, they observed that it lowered cholesterol levels without the classic thyroid risks to the heart and bone, The study was supported by Karo Bio in Sweden, a company that is developing the drug for its cholesterol-lowering effects.

Over three decades, Irwin Klein, MD, an endocrinologist at the Feinstein Institute, has been at the forefront of researching the connection between thyroid and heart health. It seemed that people with underactive thyroid glands also had high cholesterol levels. These high cholesterol levels were dramatically reduced with thyroid hormone replacement. But the problem in using thyroid hormone for cholesterol lowering is the side effects of an overactive thyroid gland: people can become anxious and have heart palpitations, muscle weakness and bone thinning.

Scientists spent years trying to develop thyroid analogs that lowered lipids without unwanted side effects. American scientists, including Dr. Klein and John D. Baxter, MD, a senior member of The Methodist Hospital Research Institute, have been working with Karo Bio scientists to solve this problem. They landed on one in particular that lowered cholesterol without any of the problems with the traditional thyroid medicines. Phase I studies showed the drug safe.

In the current Phase II study, they reported that it was both safe and effective in lowering cholesterol. What is not known from this study is whether this lowering of cholesterol will ultimately protect patients from heart disease. Dr. Klein said he thinks it may work to reduce cardiovascular disease. "Every percentage that you lower cholesterol, you lower the risk for heart disease," he said. "High cholesterol is the single most modifiable risk factor." About one in three people have cholesterol levels that are higher than the national guidelines set by federal agencies.

Jens Kristensen, a scientist at Karo Bio and the lead author on the study, and his colleagues also found that the experimental medicine lowered a cholesterol product in the blood called lipoprotein A, which is damaging to the heart. There are no available medicines that lower lipoprotein A and Eprotirome lowered the levels by 33 percent.

Since cholesterol lowering is a surrogate marker for heart disease, the scientists will have to conduct other studies to test whether it does in fact reduce heart disease. The next phase of testing must include larger numbers of patients. If the results hold, it could ultimately be used as an alternative to statins. A small percentage of patients can't take statins, either because they don't work to lower cholesterol for them or they suffer from unrelenting side effects such as muscle pains, myopathy and tiredness.


'/>"/>

Contact: Jamie Talan
jtalan@nshs.edu
516-562-1232
North Shore-Long Island Jewish (LIJ) Health System
Source:Eurekalert

Related medicine news :

1. Thyroid Hormone Analogue for Treating High Cholesterol
2. Thyroid Disease: The Hidden Epidemic
3. No End In Sight To The Armour Thyroid Shortage?
4. Stain repellent chemical linked to thyroid disease in adults
5. It's January...Do You Know Where Your Thyroid Is? Thyroid Awareness Month Focuses on Millions of Undiagnosed Americans with Thyroid Problems
6. Low Thyroid Levels May Up Need for Assisted Delivery
7. Pregnancy Complication May Be Linked to Thyroid Problems
8. Thyroid Cancer Higher in Volcanic Areas
9. Newly revised guidelines for managing thyroid cancer published in Thyroid journal
10. Thyroid surgery safe for older patients, study finds
11. Studies Evaluate Thyroid Treatment During Pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/18/2017)... ... 2017 , ... Butler Mobility invited Ken Matthews to visit its manufacturing facility ... Ken was impressed with the safety and reliability of the Stannah Stairlift as well ... This endorsement by Ken Matthews can be heard on News Radio WHP 580 ...
(Date:2/18/2017)... Texas (PRWEB) , ... February 17, 2017 , ... Park ... Moore’s “Oh Behave” Show on the Pet Life Radio network. The episode, which ... a number of topics including: what factors led to Park Cities Pet Sitter’s being ...
(Date:2/18/2017)... ... February 18, 2017 , ... A new directory from ... points to easily connect elderly veterans of America's armed forces to a range ... also conveys material on this year's increase in the Veterans Pension with Aid ...
(Date:2/17/2017)... ... 2017 , ... While EHR data has revolutionized the nursing ... workstation designed to reduce nursing fatigue while enhancing productivity. Based on field experience ... lightweight, highly mobile, multi-functional alternative to the limitations of handheld computing. , Nurses ...
(Date:2/17/2017)... FL (PRWEB) , ... February 17, 2017 , ... ... software tools that allow for the electronic prescribing of controlled and non-controlled substances ... , Ninety percent of pharmacies in the United States now accept electronic prescriptions, ...
Breaking Medicine News(10 mins):
(Date:2/16/2017)... 2017  Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ... announced that executive management will participate in the RBC ... 22-23, 2017. Adrian Adams , Chief Executive Officer, ... p.m. local time on Wednesday, February 22, 2017. ... event may be accessed from the Investors section of ...
(Date:2/16/2017)... 2017  AcelRx Pharmaceuticals, Inc. (Nasdaq: ... the development and commercialization of innovative therapies for ... Vincent J. Angotti has been appointed ... company,s board of directors, effective Monday, March 6, ... experience leading executive and commercial teams at public ...
(Date:2/16/2017)... Feb 16, 2017 Research and Markets has ... Market Analysis & Trends - Function, Application, Cancer Type, Technology - ... ... Diagnostics Market is poised to grow at a CAGR of around ... 2025. Some of the prominent trends that ...
Breaking Medicine Technology: