Navigation Links
Thyroid Hormone Could One Day Treat Osteoporosis
Date:3/10/2008

Animal experiments show thyroid stimulating hormone prevented bone loss

MONDAY, March 10 (HealthDay News) -- In experiments with rats and mice, scientists have found that thyroid stimulating hormone can prevent the bone loss associated with osteoporosis and may even restore lost bone.

The finding raises the possibility that thyroid stimulating hormone (TSH) might one day provide treatment for women with severe cases of postmenopausal osteoporosis, the researchers said.

"We found that TSH, which is a hormone that was thought to be exclusively involved in the release of thyroid hormones, which are essential for the homeostasis of the body, can directly affect bone remodeling," said lead researcher Dr. Mone Zaidi, a professor of medicine and physiology and director of the Mount Sinai Bone Program at Mount Sinai School of Medicine in New York City.

TSH inhibits the process of bone reabsorption by the body, Zaidi said. "This is a process that is fundamental for the renewal of the skeleton. Throughout life, old bone is replaced by new bone," he said. "Osteoporosis occurs when this process is exaggerated, and bone removal outpaces bone replacement."

In earlier research with mice, Zaidi's group found that TSH could actually suppress bone reabsorption. For the new study, the researchers wanted to see if TSH could stop bone reabsorption when the reabsorption rates were as high as they are in osteoporosis.

To show the benefits of TSH in preventing bone loss, Zaidi's team studied rats whose ovaries had been removed, which induced menopause-related osteoporosis. The researchers then gave the rats injections of TSH often as far apart as two weeks.

The researchers found that injections of TSH prevented bone loss and actually increased bone strength. "In addition, in rats, TSH actually restored the lost bone," Zaidi said.

The findings were published in the March 10 issue of the Proceedings of the National Academy of Sciences.

There had been a fear that injections of TSH would release thyroid hormones, which could have unwanted effects. However, Zaidi and his colleagues found that this was not the case with the animals they studied.

Zaidi said TSH is already used in humans to treat thyroid disorders. "We might be able to use the same drug for different purposes, a much larger purpose than it has ever been employed for," he said.

Dr. Stephen Honig, director of the Osteoporosis Center at the Hospital for Joint Diseases in New York City, said the idea of treating the bone disease with TSH is intriguing. But, it's far from certain that the beneficial effects seen in rodents would apply to humans. And other problems related to the use of TSH would need to be solved, he said.

"This is a very interesting animal study that strongly suggests that thyroid stimulating hormone may have anti-reabsorption effects on bone," Honig said. However, he noted that TSH can cause hyperthyroidism -- an overactive thyroid gland -- that can unleash serious problems with the body's metabolism.

"One question for TSH will be how often will it induce hyperthyroidism and can dose adjustments minimize this without impacting its bone-strengthening effects," Honig said. "The [study] authors suggest that, so far, hyperthyroidism has not been a problem, at least in a group of postmenopausal women being treated with TSH for thyroid cancer."

More information

For more on osteoporosis, visit the U.S. National Library of Medicine.



SOURCES: Mone Zaidi, M.D., Ph.D., professor of medicine and physiology, and director, Mount Sinai Bone Program, Mount Sinai School of Medicine, New York City; Stephen Honig, M.D., director, Osteoporosis Center, Hospital for Joint Diseases, New York City; March 10, 2008, Proceedings of the National Academy of Sciences


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Does artificial intelligence help clinicians to recognize atrophic gastritis with thyroid disease?
2. Newly discovered role of thyroid hormone during pregnancy
3. Combination of Thyroid Medicines Not Necessary
4. Mailman School PH study finds increase in thyroid diseases risk from exposure at Chernobyl
5. Early detection critical in treating pediatric thyroid cancer
6. Thyroid treatment no quick fix for weight loss in children
7. Better detection accounts for increase in cases of thyroid cancer
8. Thyroid Test Wont Help Pregnant Mom, Baby
9. Fluoride Damages the Thyroid, Report Shows
10. PREOS(R) Granted U.S. Orphan Drug Status for Treatment of Hypoparathyroidism
11. Low levels of PYY hormone a very early indicator of type 2 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Thyroid Hormone Could One Day Treat Osteoporosis
(Date:4/29/2016)... ... April 29, 2016 , ... Shamangelic Healing, Sedona ... Onnit brand Alpha BRAIN and New Mood Daily-Stress Formula for brain optimization and ... products to the store is just one more way Shamangelic Healing supports people’s ...
(Date:4/29/2016)... ... April 29, 2016 , ... Dr. ... of best seller "LOVE, MEDICINE and MIRACLES") addresses touchy topics related to Death ... podcasted thereafter . Dr. Bernie Siegel, author of a plethora of essential ...
(Date:4/29/2016)... , ... April 29, 2016 , ... ... reveals that infants born with severe congenital diaphragmatic hernia have better survival rates ... with congenital diaphragmatic hernia (CDH)—a condition where the diaphragm fails to form completely, ...
(Date:4/29/2016)... ... April 29, 2016 , ... World Patent Marketing ... an exercise invention which aids in proper muscle development. , "The Gym & ... Creative Director of World Patent Marketing. "Globalization has threatened the future growth of ...
(Date:4/29/2016)... New York, NY (PRWEB) , ... April 29, 2016 , ... New York City based ... surgery . This surgery is a very effective way to treat obstructive sleep apnea. Dr. ... , Orthognathic surgery is a procedure that involves one or both jaw bones. This ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 2016 Oramed Pharmaceuticals Inc. (NASDAQ: ... focused on the development of oral drug delivery systems, announced ... 2016 conference, presented by Joseph Gunnar & Co. ... New York . Nadav Kidron , CEO of ... Presentation Details:   PIONEERS 2016, presented ...
(Date:4/28/2016)... , April 28, 2016  ValGenesis, ... Lifecycle Management Solutions (VLMS) today announced that ... services for sufferers of chronic kidney failure ... to manage their corporate validation process. The ... a software solution to manage their validation ...
(Date:4/28/2016)... 28, 2016 New market ... is a report that provides an overview of ... pipelines by identifying new targets and MOAs to ... Profiles discussed in this H1 2016 Osteoarthritis Pipeline ... AbbVie Inc., Abiogen Pharma S.p.A., Ablynx NV, Achelios ...
Breaking Medicine Technology: