Navigation Links
Thyroid Hormone Could One Day Treat Osteoporosis
Date:3/10/2008

Animal experiments show thyroid stimulating hormone prevented bone loss

MONDAY, March 10 (HealthDay News) -- In experiments with rats and mice, scientists have found that thyroid stimulating hormone can prevent the bone loss associated with osteoporosis and may even restore lost bone.

The finding raises the possibility that thyroid stimulating hormone (TSH) might one day provide treatment for women with severe cases of postmenopausal osteoporosis, the researchers said.

"We found that TSH, which is a hormone that was thought to be exclusively involved in the release of thyroid hormones, which are essential for the homeostasis of the body, can directly affect bone remodeling," said lead researcher Dr. Mone Zaidi, a professor of medicine and physiology and director of the Mount Sinai Bone Program at Mount Sinai School of Medicine in New York City.

TSH inhibits the process of bone reabsorption by the body, Zaidi said. "This is a process that is fundamental for the renewal of the skeleton. Throughout life, old bone is replaced by new bone," he said. "Osteoporosis occurs when this process is exaggerated, and bone removal outpaces bone replacement."

In earlier research with mice, Zaidi's group found that TSH could actually suppress bone reabsorption. For the new study, the researchers wanted to see if TSH could stop bone reabsorption when the reabsorption rates were as high as they are in osteoporosis.

To show the benefits of TSH in preventing bone loss, Zaidi's team studied rats whose ovaries had been removed, which induced menopause-related osteoporosis. The researchers then gave the rats injections of TSH often as far apart as two weeks.

The researchers found that injections of TSH prevented bone loss and actually increased bone strength. "In addition, in rats, TSH actually restored the lost bone," Zaidi said.

The findings were published in the March 10 issue of the Proceedings of the National Academy of Sciences.

There had been a fear that injections of TSH would release thyroid hormones, which could have unwanted effects. However, Zaidi and his colleagues found that this was not the case with the animals they studied.

Zaidi said TSH is already used in humans to treat thyroid disorders. "We might be able to use the same drug for different purposes, a much larger purpose than it has ever been employed for," he said.

Dr. Stephen Honig, director of the Osteoporosis Center at the Hospital for Joint Diseases in New York City, said the idea of treating the bone disease with TSH is intriguing. But, it's far from certain that the beneficial effects seen in rodents would apply to humans. And other problems related to the use of TSH would need to be solved, he said.

"This is a very interesting animal study that strongly suggests that thyroid stimulating hormone may have anti-reabsorption effects on bone," Honig said. However, he noted that TSH can cause hyperthyroidism -- an overactive thyroid gland -- that can unleash serious problems with the body's metabolism.

"One question for TSH will be how often will it induce hyperthyroidism and can dose adjustments minimize this without impacting its bone-strengthening effects," Honig said. "The [study] authors suggest that, so far, hyperthyroidism has not been a problem, at least in a group of postmenopausal women being treated with TSH for thyroid cancer."

More information

For more on osteoporosis, visit the U.S. National Library of Medicine.



SOURCES: Mone Zaidi, M.D., Ph.D., professor of medicine and physiology, and director, Mount Sinai Bone Program, Mount Sinai School of Medicine, New York City; Stephen Honig, M.D., director, Osteoporosis Center, Hospital for Joint Diseases, New York City; March 10, 2008, Proceedings of the National Academy of Sciences


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Does artificial intelligence help clinicians to recognize atrophic gastritis with thyroid disease?
2. Newly discovered role of thyroid hormone during pregnancy
3. Combination of Thyroid Medicines Not Necessary
4. Mailman School PH study finds increase in thyroid diseases risk from exposure at Chernobyl
5. Early detection critical in treating pediatric thyroid cancer
6. Thyroid treatment no quick fix for weight loss in children
7. Better detection accounts for increase in cases of thyroid cancer
8. Thyroid Test Wont Help Pregnant Mom, Baby
9. Fluoride Damages the Thyroid, Report Shows
10. PREOS(R) Granted U.S. Orphan Drug Status for Treatment of Hypoparathyroidism
11. Low levels of PYY hormone a very early indicator of type 2 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Thyroid Hormone Could One Day Treat Osteoporosis
(Date:6/27/2016)... , ... June 27, 2016 , ... ... mental health professionals, announced today its affiliation with Tennessee Counseling Association. ... to the network of the Tennessee Counseling Association, adding exclusive benefits and promotional ...
(Date:6/26/2016)... , ... June 26, 2016 , ... On June 10-11, ... of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, ... the city’s history as home to some of the world’s leading providers of cereal ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American Institutes ... Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , ... advance care planning, healthcare costs and patient and family engagement. , AIR researchers ...
(Date:6/25/2016)... ... 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his ... David Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps ... in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 27, 2016 Jazz Pharmaceuticals plc (Nasdaq: ... the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended ... Pharmaceuticals, Inc. ("Celator"; Nasdaq: CPXX ) expired ... Time). As previously announced on May 31, ... merger agreement under which Jazz Pharmaceuticals has commenced a ...
(Date:6/24/2016)... , June 24, 2016  Consumers have ... and regulators/payers have placed more emphasis on patient ... patient support programs in the pharmaceutical industry have ... medications. Consequently, pharmaceutical companies are focusing on becoming ... are providing products and services that improve health. ...
(Date:6/24/2016)...   Bay Area Lyme Foundation , collaborating ... for Tick Borne Illness , Harvard Medical School ... Medicine, University of California, Berkeley, and the Veterans ... finalists of Lyme Innovation , the first ... scientists, clinicians, researchers, entrepreneurs, and investors from several ...
Breaking Medicine Technology: