Navigation Links
Thrombosis patients face greater risks than previously believed
Date:12/2/2008

This release is available in French.

Deep venous thrombosis (DVT), the formation of blood clots in the lower limbs, is the third-most common vascular disease in North America after heart attack and stroke, and is a frequent complication in hospitalized patients. DVT is a potentially serious condition that can lead to rapid death from pulmonary embolism if untreated, and has become such a serious health concern that the U.S. Surgeon General and the Canadian Safer Healthcare Now! coalition both recently issued highly publicized calls to action to reduce the number of cases of DVT in high risk groups, in part by improving the adoption of preventative measures like the early administration of blood thinners.

However, researchers at McGill University and the affiliated Jewish General Hospital along with colleagues from Universit de Montral, McMaster University and other institutions warn that, beyond the well-known risks of pulmonary embolism, DVT patients also face postthrombotic syndrome (PTS), a poorly understood, long-term complication not addressed by traditional treatment approaches like blood thinners. Their conclusions, derived from a large, multicentre Canadian study, were published in the November issue of the Annals of Internal Medicine.

The study followed 387 patients at eight hospital centres in Quebec and Ontario for two years, the researchers said, the first multicentre study of PTS ever undertaken in North America.

"Incredibly, we found as many as 43 per cent of the patients developed postthrombotic syndrome, and one-third of those had moderate to severe cases," said McGill's Dr. Susan R. Kahn, lead author of the study. "The syndrome is characterized by persistent leg pain and swelling, and in severe cases, patients can develop painful leg ulcers which are very difficult to treat.

"Contrary to popular belief, DVT doesn't just affect older people, it can affect adults of all ages," explained Kahn, an associate professor at McGill's Faculty of Medicine and Director of the Thrombosis Program and Associate Director of the Centre for Clinical Epidemiology & Community Studies at the JGH. "Developing postthrombotic syndrome and similar complications have been shown to lead to significant disability, lost workdays and very poor quality of life."

In addition to simply documenting the incidence of PTS, Kahn and her colleagues also attempted to identify risk factors that made certain patients more likely than others to develop it. They discovered that older patients, patients who had suffered a previous bout of DVT and patients with larger blood clots at the time of diagnosis faced a greater risk of developing PTS. Moreover, they also discovered that the risk of developing PTS was far higher in patients still experiencing leg symptoms one month after DVT was first diagnosed and treated.

"This suggests that physicians can predict if a patient is likely to develop chronic PTS as early as one month after DVT diagnosis," Kahn said. "Our results show that current modalities to treat acute DVT are not effective in preventing chronic complications of DVT, and emphasize the need for additional research in the prevention and treatment of PTS."


'/>"/>

Contact: Mark Shainblum
mark.shainblum@mcgill.ca
514-398-2189
McGill University
Source:Eurekalert

Related medicine news :

1. Innovative Deep Vein Thrombosis Treatment Yields Priceless Payoff
2. Eisai Inc. Supports Acting Surgeon Generals Call to Action to Prevent Deep Vein Thrombosis and Pulmonary Embolism
3. The U.S. Surgeon General Issues National Call-to-Action on Deep-Vein Thrombosis (DVT) and Pulmonary Embolism (PE)
4. Coalition to Prevent Deep-Vein Thrombosis (DVT) Turns Awareness Into Action as it Declares First-Of-Its-Kind National DVT Screening Day
5. Coalition to Prevent Deep-Vein Thrombosis (DVT) Seeks New Icon to Raise Awareness and Increase Dialogue
6. New therapy effectively treats deep vein thrombosis
7. Portal vein thrombosis is common in extraportal vein obstruction
8. Patients Photos Help Boost Radiologists Accuracy
9. Leaders at Henry Ford Health System and Memorial Hermann Healthcare System Awarded for Commitment to Creating Safer, More Transparent Environments for Patients
10. Preoperative radiation may improve survival rates in advanced rectal cancer patients
11. Eisai Will Initiate First Head-to-Head Study Comparing Dacogen(R) (decitabine for injection) and Vidaza(R) (azacitidine) in Patients with Myelodysplastic Syndromes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... ... March 22, 2017 , ... University Orthopedics ... Orthopedic Surgery, Division of Hand, Upper Extremity and Microvascular Surgery at Newport Hospital. ... board-certified in both Orthopedics and Hand Surgery. , As the leader of ...
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... ... protection assistance and financial consultations to families and business owners in the greater ... for the local American Cancer Society Relay For Life event. , Each year, ...
(Date:3/22/2017)... ... March 22, 2017 , ... The Zabbia Insurance Agency, ... families and business owners in the greater Nassau County area, is embarking on ... , Every 3 minutes, someone in America is diagnosed with blood cancer. Every ...
(Date:3/22/2017)... ... ... HumanHaus is proud to announce the launch of its newest invention on ... was invented, but our customers today are busy, energetic, multi-taskers that live in a ... nesters and retired that want to travel. The Sweep&Stand is a self-standing ...
(Date:3/22/2017)... San Diego, CA (PRWEB) , ... March 22, 2017 , ... ... Specialty Health Inc. as one of San Diego’s Best and Brightest in Wellness® ... innovative healthcare strategies and its model use of best practices in wellness for its ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... , March 22, 2017  Varex Imaging Corporation ... entered into a renewed three-year pricing agreement with Toshiba ... supply its computed tomography (CT) tubes for integration into ... This renewed agreement will be effective April 1, 2017. ... this renewed agreement are estimated to be in the ...
(Date:3/22/2017)... Ill. , March 22, 2017 ... innovative solutions for patients who suffer from advanced ... management team. Recent hires include experienced medtech executives ... (CMO), Richard Powers , Chief Information Officer ... of Manufacturing and Operations, who bring a wealth ...
(Date:3/22/2017)... SAN DIEGO , March 22, 2017 /PRNewswire/ ... company, announced today that it has entered into ... direct placement of 1,312,000 shares of common stock ... aggregate gross proceeds of $3,148,800.  The offering is ... 2017, subject to satisfaction of customary closing conditions. ...
Breaking Medicine Technology: