Navigation Links
ThromboGenics Begins Preclinical Development of Anti-VPAC Antibody for Thrombocytopenia
Date:11/13/2007

LEUVEN, Belgium, November 14 /PRNewswire/ --

- Key Research Findings Published in the Leading Medical Journal `Blood' Validate Drug Target

ThromboGenics NV (Euronext Brussels: THR), a biotechnology company focused on vascular disease, announces today that it will progress with the development of its novel anti-VPAC(1) antibody for the treatment of thrombocytopenia, including chemotherapy-induced thrombocytopenia.

Thrombocytopenia, which is the reduced number of platelets in blood, is a common severe side effect of chemotherapy and increases the risk of bleeding and severity of haemorrhage, therefore causing the delay or even discontinuation of treatment in cancer patients. There is a high medical need to find a therapeutic that could reduce thrombocytopenia by accelerating platelet production. Blood transfusion, the current standard of care for this condition, offers only a temporary solution for these patients and is associated with significant cost and risk.

Researchers at the University of Leuven and ThromboGenics have developed a novel therapeutic approach, showing that the inhibition of VPAC could stimulate the production of platelets. ThromboGenics has now identified and selected a lead antibody against VPAC to enter preclinical development. VPAC is a receptor present at the surface of bone marrow cells called megakaryocytes, which, when mature, produce platelets. Research published yesterday in Blood describes how the inhibition of VPAC could promote megakaryocyte differentiation. Blood is the official journal of the American Society of Hematology (ASH).

Prof. Desire Collen, CEO and Chairman of ThromboGenics, commented: "Thrombocytopenia is a severe complication of cancer patients receiving chemotherapy, and for which there is little therapeutic alternative. I am very pleased to advance our thrombocytopenia programme to preclinical development, which I hope will confirm the potential of our approach published in Blood. This highlights the novelty of our programme compared to other agents in development for treatment of this serious condition."

Reference

Blood First Edition Paper, prepublished online, 13 November 2007, PACAP and its receptor VPAC1 regulate megakaryocyte maturation: therapeutic implications.

Kathleen Freson, Karen Peeters, Rita De Vos, Christine Wittevrongel, Chantal Thys, Marc F Hoylaerts, Jos Vermylen and Chris Van Geet.

(1) VPAC: Vasoactive Intestinal Peptide/Pituitary Adenylyl Cyclase Activating Peptide Receptor-1

About ThromboGenics

ThromboGenics is a biotechnology company focused on discovery and development of biopharmaceuticals for the treatment of a range of vascular diseases. The Company has several programs in Phase II clinical development including microplasmin, which is being evaluated as a treatment for vitreoretinal disorders and as a thrombolytic agent for vascular occlusive diseases, including acute stroke. ThromboGenics is also developing novel antibody therapeutics in collaboration with BioInvent International; these include TB-402 (Anti-Factor VIII), scheduled to enter Phase II clinical development in 2008, and TB-403 (Anti-PlGF), which is expected to proceed to Phase I clinical trials by the end of 2007. ThromboGenics has built strong links with the University of Leuven and has exclusive rights to certain therapeutics developed at the University. ThromboGenics is headquartered in Leuven, Belgium and has subsidiaries in Dublin, Ireland and New York, U.S. The Company is listed on Eurolist by Euronext Brussels under the symbol THR. More information is available at http://www.thrombogenics.com.

Important information about forward-looking statements

Certain statements in this press release may be considered "forward-looking". Such forward-looking statements are based on current expectations, and, accordingly, entail and are influenced by various risks and uncertainties. The Company therefore cannot provide any assurance that such forward-looking statements will materialize and does not assume an obligation to update or revise any forward-looking statement, whether as a result of new information, future events or any other reason. Additional information concerning risks and uncertainties affecting the business and other factors that could cause actual results to differ materially from any forward-looking statement is contained in the prospectus.

For further information please contact:

ThromboGenics

Prof Desire Collen, CEO

Patrik De Haes, COO

Tel: +32(0)16-34-61-94

Citigate Dewe Rogerson

Valerie Auffray/ David Dible / Amber Bielecka

Tel: +44(0)207-638-95-71

valerie.auffray@citigatedr.co.uk


'/>"/>
SOURCE ThromboGenics NV
Copyright©2007 PR Newswire.
All rights reserved

Related medicine news :

1. Provectus Pharmaceuticals, Inc. Begins Phase 2 Clinical Trial for Metastatic Melanoma
2. PA Department of Public Welfare Begins Outreach to Medical Assistance Consumers Following Burglary at State Office Building
3. China Shenghuo Pharmaceutical Holdings, Inc. Begins Full-Scale Launch of 12Ways(R) Chinese Herbal Skin Care Product Line
4. Most comprehensive study of mercury in dental fillings begins
5. Eye Safety Begins at Home
6. MetLife Foundation Begins New Phase of Award-Winning Parenting Skills Campaign in Collaboration with the Partnership for a Drug-Free America(R)
7. OmniGuide Begins European Commercialization
8. From Microscope to Stethoscope: the MUHCs distinguished public lecture series begins a second seaso
9. From microscope to stethoscope: The MUHCs public lecture series begins its 2nd season tomorrow
10. North Shore-LIJ Health System Begins Online Posting of Hospital Infection Rates, Other Performance Information
11. Healthy Weight Loss Begins With What You Permit to Enter Your Mind, More So Than Even Your Mouth!
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... Mediaplanet’s newest campaign, ... standing as living proof that attitude and determination can combine into the most ... spike around the holidays. This campaign will offer patients a new-found hope, by ...
(Date:12/2/2016)... Honolulu, Hawaii (PRWEB) , ... December 02, 2016 ... ... 3, 2016 at the Hyatt Regency Waikiki Beach Resort and Spa in Honolulu, ... (CME) in the field of pain management. , The demand for supplemental ...
(Date:12/2/2016)... California (PRWEB) , ... December 02, 2016 , ... "Pro3rd ... allow FCPX editors to create versatile lower third titles with just a few clicks ... Pro3rd Accents Volume 2 includes 30 lower third animations. Choose from various styles with ...
(Date:12/2/2016)... , ... December 02, 2016 , ... ‘Tis the season ... of $1,000 each from the National Family Partnership and the Drug Enforcement Administration as ... decorated their homes and the 10 winning schools who decorated their campuses with this ...
(Date:11/30/2016)... ... November 30, 2016 , ... Center For Discovery, a nationally ... of a new eating disorder treatment center location in Palm Beach Gardens, Florida.  The ... adolescents, both males and females ages 10 and older with eating disorders, including ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... Dec 1, 2016 Research and Markets ... Delivery in Cancer - Technologies, Markets and Companies" to their ... , , ... management of cancer The market value of drug delivery ... estimates from 2015-2025 are given according to organs involved and the ...
(Date:12/2/2016)... Dec. 1, 2016 Around the corners of ... and each habitable land present over earth. Cancer has ... once in a life time this is because of ... until now. Given the steady increase in global cancer ... the spiraling healthcare costs of treatment, there is increasing ...
(Date:12/2/2016)... , Dec. 2, 2016 Allergan plc (NYSE: ... additional information on its previously announced Accelerated Share Repurchase (ASR) ... ... As previously announced, the Company entered into ... which the Company will repurchase $10 billion of its ordinary ...
Breaking Medicine Technology: