Navigation Links
Three Kids Dead From Codeine After Surgery: FDA
Date:8/15/2012

WEDNESDAY, Aug. 15 (HealthDay News) -- Following the deaths of three children and the near death of a fourth, U.S. health officials are warning about the risks of giving the pain reliever codeine to certain children following surgery.

The Food and Drug Administration said the four youngsters, all between 2 to 5 years old, received typical doses of codeine after having their tonsils or adenoids removed as a treatment for obstructive sleep apnea, a disorder characterized by disrupted breathing during sleep. The child who didn't die suffered near-fatal respiratory depression.

The youngsters developed adverse reactions within a day or two of taking the prescription medication, and the researchers suspect they were "ultra-rapid metabolizers."

Codeine, a narcotic also used for coughs, is converted to morphine in the liver, and in some people this conversion occurs faster and more completely than in others because of their genetic makeup. Giving such children codeine after tonsillectomy and/or adenoidectomy may increase their risk of breathing problems and death, the FDA said in a statement Wednesday.

"[The] FDA wants parents and caregivers to be aware of the warning signs that could indicate their child is having trouble breathing because of this higher morphine level," the agency said.

Between one and seven of every 100 people are considered "ultra-rapid metabolizers," the researchers said. Although rare, this genetic variation is more common among certain ethnic groups. North African and Ethiopian populations account for 29 percent of "ultra-rapid metabolizers," while 1 percent to 2 percent of northern Europeans are affected.

The only way people can know if they are ultra-rapid metabolizers is to undergo a genetic test.

The FDA issued the following guidelines for parents and caregivers:

  • Give codeine only as needed for pain relief, not on a set schedule.
  • Prescribe the lowest possible dose of codeine for the shortest time possible.
  • Never give children more than six doses of codeine daily.
  • Watch children closely following surgery for signs of a morphine overdose, including unusual sleepiness; confusion; shallow, loud or labored breathing; and blue lips or blueness around the mouth.

Parents who notice these symptoms should dial 911 and seek immediate medical attention, the researchers advised.

"The most important thing is that caregivers should tell the 911 operator or emergency-department staff that their child has been taking codeine and is having breathing problems," said Dr. Bob Rappaport, director of the Division of Anesthesia, Analgesia and Addiction Products at the FDA's Center for Drug Evaluation and Research.

"The FDA is currently conducting a review of adverse event reports and other information to determine if there are additional cases of inadvertent overdose or death in children taking codeine, and if these adverse events occur during treatment of other kinds of pain, such as post-operative pain following other types of surgery or procedures," Rappaport said.

Parents should talk to their child's doctor about any concerns they have about the use of codeine, the FDA said.

More information

The U.S. National Institutes of Health provides more information on codeine.

-- Mary Elizabeth Dallas

SOURCE: U.S. Food and Drug Administration, news release, Aug. 15, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Codeine After Surgery Could Endanger Certain Kids: Study
2. Parents Can Adapt, Thrive After Empty Nest
3. Radiation after lumpectomy helps prevent need for mastectomy in early stage breast cancer
4. Study: Majority of older, early-stage breast cancer patients benefit from radiation after lumpectomy
5. Smelling a skunk after a cold
6. Experts issue recommendations for treating thyroid dysfunction during and after pregnancy
7. 1 in 3 post-partum women suffers PTSD symptoms after giving birth
8. A new model for predicting recovery after spinal cord injury
9. Alzheimers Progression Slower After 80: Study
10. Timing of antibiotics important in reducing infections after C-section
11. Childbirth After 30 Lowers Risk of Endometrial Cancer: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Three Kids Dead From Codeine After Surgery: FDA
(Date:1/19/2017)... Georgia (PRWEB) , ... January 19, 2017 , ... ... Surgeons hosts the Atlanta Breast Surgery Symposium, a conference where hundreds of surgeons ... advancements in breast surgery. Covering topics from cosmetic breast augmentation to ...
(Date:1/18/2017)... ... January 18, 2017 , ... A recent video posting of a ... about the benefits of fidgeting to relieve stress and anxiety. No one was ... Think Ink Pen had just completed a successful Kickstarter campaign raising $67,000 on the ...
(Date:1/18/2017)... ... January 18, 2017 , ... Visually learn ... one doctor-recommended OTC antiperspirant, Certain Dri. , Excessive sweating and hyperhidrosis are common ... created this infographic to explain the seven types of hyperhidrosis. This visual creates ...
(Date:1/18/2017)... ... January 18, 2017 , ... ... industry’s leading journal and most-read publication among specialty pharmacists and pharmacy professionals, ... through its Strategic Alliance Partnership (SAP) program, announced Brian Haug, president of ...
(Date:1/18/2017)... (PRWEB) , ... January 18, 2017 , ... ... to announce that their Vice President of Franchise Development, Paula Turner Pizarro, was ... award-winning business program, which features the insights of top business leaders from across ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... CLEVELAND , Jan. 18, 2017  ViewRay, ... the world,s first and only clinical MRI-guided radiation ... gross proceeds of approximately $26.1 million through a ... Puissance Capital Management led the financing and was ... OrbiMed Advisors, LLC and Kearny Venture Partners, and ...
(Date:1/19/2017)... , Jan. 18, 2017  Magnetic Insight Inc., ... entered into an agreement with inviCRO LLC to ... MPI imaging system based on inviCRO,s VivoQuant™ visualization ... distributed as a complete MPI solution package with ... nanoparticle or cell imaging in vivo. ...
(Date:1/19/2017)... 18, 2017 The drug delivery technology market ... from USD 1,179.20 billion in 2016, at a CAGR ... of chronic diseases, increasing demand for biologics, technological advancements, ... growth of this market. Whereas, self-administration & home care ... significant growth opportunities for players operating in this market. ...
Breaking Medicine Technology: