Navigation Links
Three Johns Hopkins researchers named Howard Hughes Medical Institute early career scientists

Three researchers at the Johns Hopkins University School of Medicine have been named early career scientists by the Howard Hughes Medical Institute (HHMI). Xinzhong Dong, Ph.D., Joshua Mendell, M.D., Ph.D., and Sinisa Urban, Ph.D., all will remain faculty at Hopkins but also become employees of HHMI, which will provide research funding and salary for the next six years.

"We are thrilled for Xinzhong, Josh and Sin for being recognized by Hughes for the quality of their work," says Chi V. Dang, M.D., Ph.D., the vice dean for research at Johns Hopkins. "At the same time, this is an honor for all of Johns Hopkins, to have not only one but three young investigators selected."

The award is given to recognize "the nation's best biomedical scientists at a critical early stage of their faculty careers, and to provide them with flexible funding to develop scientific programs of exceptional merit."

Dong, an assistant professor of neuroscience and member of Hopkins' Institute of Basic Biomedical Sciences Center for Sensory Biology, has been at Johns Hopkins since 2004. His team is taking a multidisciplinary approach to understanding the mechanisms behind sensation, including pain, itch and touch. All three so-called somatosensations are controlled by nerves in the dorsal root ganglia, a bundle of nerves that carries information through the spinal cord into the brain. To do their research, the team has developed new molecular tools to examine nerve cell circuitry and communication. They would like to learn which nerve cells mediate which sensation, how these nerve cells relay information to other cells and which proteins within these cells actually sense an itch or gentle touch.

Mendell has been an assistant professor of pediatrics and member of Hopkins' McKusick-Nathans Institute of Genetic Medicine since 2004. His team studies microRNAs, how they function and how they are controlled in normal cells and under disease conditions. MicroRNAs, small RNA molecules that affect the stability of messages and the amount of proteins made by genes, can control many aspects of development and cell function and often are altered in diseases such as cancer. Mendell's team was one of the first to identify microRNAs that are involved in cancer-promoting molecular pathways. In addition to their work on cancer, the team also studies how microRNAs are controlled within a cell and how that control is lost in disease states.

Urban has been an assistant professor of molecular biology and genetics since 2006. His team studies enzymes called rhomboid proteases that are found in a cell's membrane. Urban discovered that rhomboid proteases catalyze a biochemical reaction that cuts proteins. His research team aims to understand the biochemical principles governing how catalysis occurs embedded within the membrane, which is a new frontier in biochemistry. They also focus on how deadly pathogens such as malaria and related parasites use rhomboid proteases to infect human cells, and how parasitic amebae use rhomboids to evade the immune system. Uniting these studies may lead to new drug development because targeting rhomboid enzymes with inhibitors may be an effective way to treat multiple infectious diseases.


Contact: Audrey Huang
Johns Hopkins Medical Institutions

Related medicine news :

1. Avidas(TM) Pharmaceuticals Introduces Scalacort(TM) DK Which Offers Three Scalp Solutions in One Patient Convenience Kit
2. Three New NextCare Immediate Care Clinic Locations Open in Colorado
3. Leader in Health Plan Cost Containment Cites Three Economy-Driven Reasons Why Self-Insured Health Plans Should Brace for Claim Increases and Fund Reserves Accordingly
4. Health Career Agents Announces Three Options for Involvement in Health Care Recruiting and Staffing
5. Three Leading Proxy Advisory Firms are Unanimous in Recommending LCA-Vision Stockholders Support the Current Board of Directors
6. Living With Grief: Diversity and End-of-Life Care' National Teleconference Offered at Three Bay Area Locations
7. Promising Three-year Data: Saving Limbs With Drug-Eluting Stents
8. Three Cetaphil(R) Products Awarded National Eczema Association Seal of Acceptance
9. United States Joins Suit Against Community Health Systems Inc. and Three of Its Hospitals in New Mexico
10. Three Healthcare GPOs to Offer Masimo Rainbow SET(R) Pulse CO-Oximetry(TM) to Their Members
11. Glass Lewis Recommends Shareholders Support LCA-Vision Board of Directors and Reject All Three Proposals by Dissident Joffe Group
Post Your Comments:
(Date:6/25/2016)... ... ... of Bruton Memorial Library on June 21 due to a possible lice infestation, as reported ... head lice: the parasite’s ability to live away from a human host, and to infest ... in the event that lice have simply gotten out of control. , As lice are ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as ... City area —Johnson is one of the first doctors to perform the treatment. ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set of ... or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, Serenity ... event. , Trauma sufferers tend to feel a range of emotions, from depression, guilt, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg ... Legal Elite. The attorneys chosen by their peers for this recognition are considered among ... Greenberg Traurig Shareholders received special honors as members of this year’s Legal Elite Hall ...
(Date:6/24/2016)... ... 24, 2016 , ... People across the U.S. are sharpening their pencils and ... essay contest in which patients and their families pay tribute to a genetic counselor ... National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 According ... by Type (Standard Pen Needles, Safety Pen Needles), Needle ... GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) - ... This report studies the market for the forecast period ... reach USD 2.81 Billion by 2021 from USD 1.65 ...
(Date:6/23/2016)... 23, 2016  MedSource announced today that it ... software solution of choice.  This latest decision demonstrates ... to their clients by offering a state-of-the-art electronic ... establishes nowEDC as the EDC platform of choice ... clients.  "nowEDC has long been a preferred EDC ...
(Date:6/23/2016)... -- In a startling report released today, National Safety Council ... comprehensive, proven plan to eliminate prescription opioid overdoses. Prescription ... are tackling the worst drug crisis in recorded U.S. history, assigned ... Kentucky , New Mexico , ... 28 failing states, three – Michigan , ...
Breaking Medicine Technology: