Navigation Links
Those aching joints could be in your genes
Date:7/5/2011

Tel Aviv A common complaint, back pain is one of the many side effects of aging. Over three quarters of the population experience it at some point, and until now, researchers have had little conclusive proof of the causes and mechanisms of the pain.

New research from Prof. Gregory Livshits of Tel Aviv University's Department of Anatomy and Anthropology at the Sackler Faculty of Medicine, however, shows that genetics are a major contributing factor to this pain and common back pain complaints may have different genetic origins. The results of their study can help identify the different mechanisms involved in back pain and lead to more effective treatment options.

The research, pursued in collaboration with a team of scientists at Kings College, London led by Prof. Tim Spector and Dr. Fran Williams, was recently published in the journal Annals of the Rheumatic Diseases.

Identical twins, identical pains

Our two-footed anatomy causes strain and subsequent deterioration of the muscular skeletal system, as do factors such as weight or physical exertion. The team's research shows genetics play a key role in lower back pain and the deterioration of intervertebral discs of the spine as well. More surprisingly, Prof. Livshits says, lower back pain and disk degeneration do not always overlap, and are caused by different genetic factors.

Preliminary testing done in Israel more than 10 years ago gave scientists their first clue to the connection between genetics and back pain. A study conducted on Arabic families revealed recurring patterns of lower back pain in family members many relatives of the same family would develop the same symptoms, even at a young age.

To further test these observations, Prof. Livshits and his team looked at a sample twin population of 2,500 individuals, comprising both identical and non-identical female twins. They tested for several potential risk factors, such as smoking, weight, physical work, vertebral disc degeneration disease as well as genetic predisposition. Researchers relied on MRIs of the spine; radiographic assessment of the body lean, fat and bone mass; and blood samples for DNA extraction, genotyping and testing blood for potential biomarkers associated with joint disease.

In non-identical twins who share half of their genetic make-up, patients were almost three times more likely to suffer from back pain if their twin did so as well. In identical twins, who share all of their genes, the patient was six times more likely to have joint disease if their twin experienced the same joint disease.

Refining genetic testing

Although the degeneration of intervertebral discs is often associated with lower back pain, researchers discovered that the two conditions could exist independently, and are also caused by different genetic factors. "We have genetic factors that affect the rate and extent of the degeneration of our discs. In fact, the genetic factors are second only to age," explains Prof. Livshits. "On the other side, we have different genetic factors that independently cause lower back pain. These are mechanisms not involved in spine degeneration."

This discovery could revolutionize the study and treatment of back pain, says Prof. Livshits. More research on the genetic causes of back pain is still required, he notes, and a broader genome search of affected and non-affected individuals is necessary.

The next step for Prof. Livshits will be an international effort that spans university labs in a number of countries, creating a consortium of research groups. Together, they will be able to combine their efforts to analyze large sets of data in the quest to solve the mysteries associated with this common complaint.


'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

Related medicine news :

1. South Carolina Attorney Says Legal Options Still Available To Those Harmed By Chantix
2. Rhode Island Settlement Reflects Homeowner Liability for Serving Alcohol to Those Under 21, Says Providence Lawyer Mark Gemma
3. Soyfoods Aid Those With Lactose Intolerance
4. National Study Reports Staggering Spending Increases Among Seniors With Chronic Conditions Through Original Medicare - Special Needs Plan Program Offers Solution For Those In Texas
5. ConsumerLab.com Finds Carcinogenic form of Chromium in Supplements, Including Those for Weight Loss
6. Radiation May Help Those With Inoperable Lung Tumors
7. Safety Should Be Priority for Those Involved in Kids Sports
8. Cognition declines 4 times faster in people with Alzheimers disease than those with no dementia
9. VoiceNation Helps Non-Profits Gather Funding for Those in Need
10. Older people and those with HIV are more vulnerable to tuberculosis
11. Should Cholesterol Drugs Be Used By Those Without High Cholesterol?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Those aching joints could be in your genes
(Date:6/26/2016)... North Carolina (PRWEB) , ... June 26, 2016 , ... ... release of a new product that was developed to enhance the health of felines. ... for centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, ... Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments in ... the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, ... at his family verbally and physically. , “When something upset him, he couldn’t control his ... it. He would throw rocks at my other children and say he was going to ...
(Date:6/24/2016)... ... ... BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a ... an hour by 2020 and then adjusting it yearly to increase at the same rate ... assure the wage floor does not erode again, and make future increases more predictable. , ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... -- Bracket , a leading clinical trial technology and ... platform, Bracket eCOA (SM) 6.0, at the 52 nd ... 2016 in Philadelphia , Pennsylvania.  A demonstration ... of its kind to fully integrate with RTSM, will be ... is a flexible platform for electronic clinical outcomes assessments that ...
(Date:6/23/2016)... 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in ... America . ... ... ... ...
Breaking Medicine Technology: