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Thomson Reuters White Paper Explores the Role of Biomarkers in Clinical Trials and Drug Development
Date:1/12/2009

PHILADELPHIA and LONDON, Jan. 12 /PRNewswire-FirstCall/ -- Thomson Reuters today announced that it has published a new white paper on the topic of biomarkers drawing on expert insight from academics and key players in the pharmaceuticals industry. Called "Biomarkers: An Indispensable Addition to the Drug Development Toolkit," it explores the role of biomarkers as evaluative tools in addressing some of the challenges seen in clinical research and their potential to improve decision making, accelerate drug development and reduce development costs.

Used as a way to measure normal biological processes in the body, pathological processes, or the response of the body to a therapeutic intervention, Biomarkers have become an essential part of clinical development because they potentially offer a faster route to market versus the conventional drug development approach, where success rates have steadily declined in recent years. Attrition rates for drugs in discovery and development are currently very high with less than 10% of tested products entering phase I trials. With increasing costs involved in the drug development process, and growing concern that fewer drugs are making it through to the marketplace each year, the pharmaceutical industry is embracing biomarkers as a way of predicting a drug candidate's performance early and with a greater degree of certainty.

"The FDA, as well as academic and research organizations, have recognized Biomarkers as having great potential to speed the development and approval of medical products," said Wendy Hamilton, vice president of product strategy and marketing, Scientific business of Thomson Reuters. "Because biomarkers can predict drug efficacy and safety more quickly than conventional clinical endpoints, they hold the potential to substantially accelerate product development, and because they help to identify earlier those drug candidates that are likely to fail, they reduce drug develo
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