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Thomas Jefferson University and hospitals tasked to find new radiation drugs
Date:5/4/2011

otecting normal tissue against the harmful effects of radiation therapy, the research serves another purpose.

"On the one hand it could help protect the cancer patient who is treated with radiation, while on the other it may help to alleviate the kind of problems that we see right now unfolding in Japan," said Dr. Rodeck.

The work being done at Jefferson is part of a major research effort to develop medical products to diagnose, prevent and treat the short- and long-term consequences of radiation exposure that's supported by the NIH's National Institute of Allergy and Infectious Disease's CMCR program.

Only seven institutions have been tasked with this charge. Thomas Jefferson University researchers are working with Chandan Guha, M.D., Ph.D, who is the principal investigator of the new CMCR recently established at Albert Einstein Medical Center in New York, one of the institutions chosen.

Their effort builds on the use of zebrafish to study molecular mechanisms of damage by radiotherapy. Dr. Dicker's laboratory program uses this model organism in conjunction with nanotechnology drugs to identify novel radiation protectors and mitigators. This latest project will take the research into mice.

The proposed experiments focus on using small molecule agents that can be taken orally and stockpiled for quick access.

"The drugs we are working on would be of potential benefit to the workers who had to go in and repair the reactor or anyone in close proximity to a disaster of this kind," Dr. Rodeck said.


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Contact: Steve Graff
stephen.graff@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert  

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