Navigation Links
There's life after radiation for brain cells
Date:8/12/2013

Scientists have long believed that healthy brain cells, once damaged by radiation designed to kill brain tumors, cannot regenerate. But new Johns Hopkins research in mice suggests that neural stem cells, the body's source of new brain cells, are resistant to radiation, and can be roused from a hibernation-like state to reproduce and generate new cells able to migrate, replace injured cells and potentially restore lost function.

"Despite being hit hard by radiation, it turns out that neural stem cells are like the special forces, on standby waiting to be activated," says Alfredo Quiones-Hinojosa, M.D., a professor of neurosurgery at the Johns Hopkins University School of Medicine and leader of a study described online today in the journal Stem Cells. "Now we might figure out how to unleash the potential of these stem cells to repair human brain damage."

The findings, Quiones-Hinojosa adds, may have implications not only for brain cancer patients, but also for people with progressive neurological diseases such as multiple sclerosis (MS) and Parkinson's disease (PD), in which cognitive functions worsen as the brain suffers permanent damage over time.

In Quiones-Hinojosa's laboratory, the researchers examined the impact of radiation on mouse neural stem cells by testing the rodents' responses to a subsequent brain injury. To do the experiment, the researchers used a device invented and used only at Johns Hopkins that accurately simulates localized radiation used in human cancer therapy. Other techniques, the researchers say, use too much radiation to precisely mimic the clinical experience of brain cancer patients.

In the weeks after radiation, the researchers injected the mice with lysolecithin, a substance that caused brain damage by inducing a demyelinating brain lesion, much like that present in MS. They found that neural stem cells within the irradiated subventricular zone of the brain generated new cells, which rushed to the damaged site to rescue newly injured cells. A month later, the new cells had incorporated into the demyelinated area where new myelin, the protein insulation that protects nerves, was being produced.

"These mice have brain damage, but that doesn't mean it's irreparable," Quiones-Hinojosa says. "This research is like detective work. We're putting a lot of different clues together. This is another tiny piece of the puzzle. The brain has some innate capabilities to regenerate and we hope there is a way to take advantage of them. If we can let loose this potential in humans, we may be able to help them recover from radiation therapy, strokes, brain trauma, you name it."

His findings may not be all good news, however. Neural stem cells have been linked to brain tumor development, Quiones-Hinojosa cautions. The radiation resistance his experiments uncovered, he says, could explain why glioblastoma, the deadliest and most aggressive form of brain cancer, is so hard to treat with radiation.


'/>"/>

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine
Source:Eurekalert

Related medicine news :

1. Healdsburg District Hospital Welcomes Theresa L. Colosi, M.D., to their Orthopaedic and Total Joint Program
2. Young girls more likely to report side effects after HPV vaccine
3. Experts Offer Advice After Yankee Pitchers Trampoline Injury
4. Breast cancer patients suffer treatment-related side effects long after completing care
5. Codeine After Surgery Could Endanger Certain Kids: Study
6. Drug May Prevent Pancreatitis After Digestive Procedure
7. Diagnostic yield of colonoscopy for melena after nondiagnostic upper endoscopy is lower than previously reported
8. After Hospitalization, Men More Likely to Show Up in ER
9. Men More Prone to Complications After Brain, Spine Surgery
10. Close Laundry Detergent Right After Use, Expert Says
11. Donor Kidney Re-Used in Second Patient After Failing in First
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2017)... Rosemont, Ill. (PRWEB) , ... June 27, 2017 , ... ... & Conditioning Association (NBSCA) have named Javair Gillett of the Houston Rockets the NBSCA ... recipient of the award is decided by NBSCA members who vote to select the ...
(Date:6/26/2017)... ... June 26, 2017 , ... Torrance dentist, Dr. Robert ... be one of the most noticeable aspects of a person’s appearance. A healthy, radiant ... is born with beautiful, balanced teeth, everyone can have the smile of their dreams ...
(Date:6/26/2017)... ... June 26, 2017 , ... A ... revolutionizing the way women look and feel about themselves and their sexual encounters. ... sexual dysfunction and urinary leakage head on with a ground breaking medical technique ...
(Date:6/25/2017)... ... June 25, 2017 , ... FCPX LUT Vintage Volume 2 ... vintage look. FCPX LUT Vintage Volume 2 contains 60 different color-grade presets, giving editors ... looks, vignettes and blurs to single out subjects, plus much more. FCPX LUT Vintage ...
(Date:6/25/2017)... CA (PRWEB) , ... June 25, 2017 , ... With a heatwave currently bearing down ... or hanging out at the pool. Being swimsuit ready is easy with laser hair removal. ... and repeat again can be a burdensome routine when all you want to do is ...
Breaking Medicine News(10 mins):
(Date:6/19/2017)... HORSHAM, Pa. , June 19, 2017  Researchers ... announced today that they will host a live, complimentary ... Perspectives from the benchtop to the real world" on ... PM EDT. This webinar will feature ... a rare look into the manipulation techniques abusers use ...
(Date:6/14/2017)... 2017  ivWatch LLC, a medical device company focused ... therapy, is pleased to announce it was the Bronze ... Supplies and Equipment at the 2017 Medical Design Excellence ... industry. The award was presented by Medical Device and ... in New York during MD&M ...
(Date:6/13/2017)... June 13, 2017 Zimmer Biomet Holdings, Inc. (NYSE ... announced that the U.S. Food and Drug Administration (FDA) has ... 2015 relating to its Zhejiang, China ... "The successful clearance of the Warning Letter related ... facility is a measure of the progress we have made ...
Breaking Medicine Technology: